SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A 144
VAL A 205
TYR A 202
VAL A 153
LEU A 102
 None
 1.15A 1s19A-5i2xA:
undetectable		 1s19A-5i2xA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG
(Homo
sapiens) 		4 / 8 GLU A 177
VAL A 120
GLU A 170
ASP A 123
 None
 1.04A 1s3zA-5i2xA:
undetectable
1s3zB-5i2xA:
undetectable		 1s3zA-5i2xA:
21.86
1s3zB-5i2xA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG
(Homo
sapiens) 		4 / 7 PHE A 173
LEU A 183
ALA A 161
ALA A 142
 None
 0.85A 2vcvG-5i2xA:
undetectable		 2vcvG-5i2xA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG
(Homo
sapiens) 		4 / 8 PHE A 173
LEU A 183
ALA A 161
ALA A 142
 None
 0.80A 2vcvP-5i2xA:
undetectable		 2vcvP-5i2xA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG
(Homo
sapiens) 		5 / 11 VAL A 205
LEU A 203
GLY A 187
PRO A 109
SER A 110
 None
 1.34A 3bjwE-5i2xA:
undetectable		 3bjwE-5i2xA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A 183
ARG A 154
SER A 165
GLY A 141
 None
 1.08A 3hcrB-5i2xA:
undetectable		 3hcrB-5i2xA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG
(Homo
sapiens) 		4 / 6 LEU A 183
LEU A 117
VAL A 146
PHE A 208
 None
 1.24A 4uswA-5i2xA:
undetectable		 4uswA-5i2xA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG
(Homo
sapiens) 		5 / 10 LEU A 181
LEU A 183
GLY A 115
SER A 147
ALA A 142
 None
 1.08A 4xj7C-5i2xA:
undetectable
4xj7D-5i2xA:
undetectable		 4xj7C-5i2xA:
22.09
4xj7D-5i2xA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG
(Homo
sapiens) 		3 / 3 ASP A 123
PHE A 171
ARG A 159
 None
 0.86A 5yw0A-5i2xA:
undetectable		 5yw0A-5i2xA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG
(Homo
sapiens) 		5 / 12 SER A 165
THR A 164
TRP A 167
PHE A 173
LEU A 117
 None
 1.38A 6a93A-5i2xA:
undetectable		 6a93A-5i2xA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5i2x ADRENOCORTICAL
DYSPLASIA PROTEIN
HOMOLOG
(Homo
sapiens) 		5 / 12 SER A 165
THR A 164
TRP A 167
PHE A 173
LEU A 117
 None
 1.37A 6a93B-5i2xA:
undetectable		 6a93B-5i2xA:
16.98