SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i32'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 10 GLY A 220
VAL A 143
GLY A 142
VAL A 219
HIS A 131
 None
 1.13A 1pwyE-5i32A:
undetectable		 1pwyE-5i32A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 GLY A 194
SER A 201
TYR A 217
PHE A 191
SER A 192
 None
 1.15A 1ri4A-5i32A:
undetectable		 1ri4A-5i32A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		4 / 5 ALA A  39
LEU A  56
GLY A 189
THR A 150
 None
 0.88A 3dl9A-5i32A:
undetectable		 3dl9A-5i32A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 LEU A 153
VAL A 181
ILE A 185
GLY A 194
HIS A 131
 None
 1.12A 3hgiA-5i32A:
undetectable		 3hgiA-5i32A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		4 / 6 ALA A  39
ILE A  59
HIS A  63
HIS A 131
 None
 1.08A 3nneG-5i32A:
undetectable		 3nneG-5i32A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 LEU A  45
THR A  46
ASP A  52
GLY A  55
ALA A  58
 None
 1.14A 3p5nA-5i32A:
2.5		 3p5nA-5i32A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 LEU A  45
THR A  46
ASP A  52
GLY A  55
ALA A  58
 None
 1.14A 3p5nB-5i32A:
2.5		 3p5nB-5i32A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1Q_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 PRO A  84
LEU A 109
VAL A 206
PHE A 211
TRP A 218
 None
 1.35A 4g1qA-5i32A:
undetectable		 4g1qA-5i32A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ICL_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 PRO A  84
LEU A 109
VAL A 206
PHE A 211
TRP A 218
 None
 1.34A 4iclA-5i32A:
undetectable		 4iclA-5i32A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 PRO A  84
LEU A 109
VAL A 206
PHE A 211
TRP A 218
 None
 1.32A 4id5A-5i32A:
undetectable		 4id5A-5i32A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IDK_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 PRO A  84
LEU A 109
VAL A 206
PHE A 211
TRP A 218
 None
 1.31A 4idkA-5i32A:
1.0		 4idkA-5i32A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 PRO A  84
LEU A 109
VAL A 206
PHE A 211
TRP A 218
 None
 1.32A 4ifvA-5i32A:
undetectable		 4ifvA-5i32A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 PRO A  84
LEU A 109
VAL A 206
PHE A 211
TRP A 218
 None
 1.32A 4ifyA-5i32A:
undetectable		 4ifyA-5i32A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 PRO A  84
LEU A 109
VAL A 206
PHE A 211
TRP A 218
 None
 1.34A 4ig3A-5i32A:
undetectable		 4ig3A-5i32A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 PRO A  84
LEU A 109
VAL A 206
PHE A 211
TRP A 218
 None
 1.30A 4kfbA-5i32A:
undetectable		 4kfbA-5i32A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 SER A 195
VAL A 206
ALA A  85
LEU A 110
VAL A  32
 None
 1.34A 4nc3A-5i32A:
undetectable		 4nc3A-5i32A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		4 / 8 THR A  87
GLY A  94
GLY A  93
VAL A  92
 None
 0.70A 4qvvK-5i32A:
undetectable
4qvvL-5i32A:
undetectable		 4qvvK-5i32A:
23.47
4qvvL-5i32A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		4 / 8 THR A  87
GLY A  94
GLY A  93
VAL A  92
 None
 0.70A 4qvvY-5i32A:
undetectable
4qvvZ-5i32A:
undetectable		 4qvvY-5i32A:
23.47
4qvvZ-5i32A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 ASN A  83
HIS A 214
PRO A 204
VAL A  32
SER A 195
 None
 1.39A 4v2gB-5i32A:
2.0		 4v2gB-5i32A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 GLY A 178
PRO A 174
ALA A 173
ALA A  72
ALA A 152
 None
 1.14A 5bw4B-5i32A:
undetectable		 5bw4B-5i32A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 ILE A 177
GLN A 108
LEU A 222
PRO A 221
LEU A 153
 None
 1.18A 5xxiA-5i32A:
undetectable		 5xxiA-5i32A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 SER A  38
VAL A 181
GLY A 182
PHE A  31
VAL A  32
 None
 1.19A 6a94A-5i32A:
2.2		 6a94A-5i32A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 GLY A 194
VAL A 143
ILE A 177
GLY A 182
ALA A 152
 None
 1.09A 6c2mA-5i32A:
undetectable		 6c2mA-5i32A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 GLY A 194
VAL A 143
ILE A 177
GLY A 182
ALA A 152
 None
 1.04A 6c2mB-5i32A:
undetectable		 6c2mB-5i32A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 GLY A  35
VAL A 128
ILE A 149
GLY A 182
ALA A 188
 None
 1.00A 6c2mD-5i32A:
undetectable		 6c2mD-5i32A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 11 SER A 192
ALA A 188
THR A 150
LEU A 153
ALA A  85
 None
 1.32A 6efnA-5i32A:
0.0		 6efnA-5i32A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 5i32 AQUAPORIN TIP2-1
(Arabidopsis
thaliana) 		5 / 12 PRO A  84
LEU A 109
VAL A 206
PHE A 211
TRP A 218
 None
 1.35A 6eliA-5i32A:
undetectable		 6eliA-5i32A:
14.18