SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i33'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 9 THR A 239
THR A 285
VAL A 319
VAL A 372
VAL A 374
 None
 1.49A 1iwjA-5i33A:
undetectable		 1iwjA-5i33A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 11 GLY A  13
GLY A 269
ILE A 271
LEU A 332
GLY A  17
 None
 1.11A 1jg3A-5i33A:
undetectable		 1jg3A-5i33A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 9 GLY A 227
GLY A  68
LEU A 224
SER A  67
ARG A  37
 None
 1.21A 1jhyA-5i33A:
undetectable		 1jhyA-5i33A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 9 GLY A 227
GLY A  68
LEU A 224
SER A  67
ARG A  37
 None
 1.22A 1l4nA-5i33A:
undetectable		 1l4nA-5i33A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 6 LEU A  12
GLU A  19
THR A 239
TYR A 329
 None
 1.50A 1qvuA-5i33A:
undetectable		 1qvuA-5i33A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 8 TYR A 237
ASP A 234
SER A 249
TYR A 329
 None
 1.32A 2bteA-5i33A:
undetectable		 2bteA-5i33A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 8 TYR A 237
ASP A 234
SER A 249
TYR A 329
 None
 1.28A 2bteD-5i33A:
undetectable		 2bteD-5i33A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 7 LEU A 101
PHE A  62
ILE A  70
GLU A 226
 None
 0.95A 2opxA-5i33A:
undetectable		 2opxA-5i33A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 SER A 247
HIS A 114
ASP A 111
 None
 0.84A 2oxtA-5i33A:
undetectable		 2oxtA-5i33A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 4 SER A 247
GLY A 251
HIS A 114
ASP A 111
 None
 1.13A 2oxtC-5i33A:
undetectable		 2oxtC-5i33A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 8 TYR A 237
ASP A 234
SER A 249
TYR A 329
 None
 1.12A 2v0gA-5i33A:
undetectable		 2v0gA-5i33A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 ARG A 310
GLU A 301
SER A 323
 None
 0.82A 2xctD-5i33A:
undetectable		 2xctD-5i33A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 7 LEU A 379
VAL A 348
THR A 350
ASP A 408
 None
 1.04A 2zaxA-5i33A:
undetectable		 2zaxA-5i33A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 LEU A  96
ALA A  61
GLY A  41
VAL A 305
THR A 304
 None
 1.02A 3c6gA-5i33A:
undetectable		 3c6gA-5i33A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 TYR A 274
TYR A 402
ILE A 346
 None
 0.78A 3eteA-5i33A:
undetectable
3eteB-5i33A:
undetectable		 3eteA-5i33A:
21.88
3eteB-5i33A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 7 GLY A 142
VAL A 116
HIS A  85
ILE A 122
 None
 0.92A 3fi0P-5i33A:
undetectable		 3fi0P-5i33A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 7 LEU A 379
VAL A 348
THR A 350
ASP A 408
 None
 1.07A 3fwgB-5i33A:
undetectable		 3fwgB-5i33A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 8 VAL A  25
ILE A 250
VAL A 253
GLY A 227
 None
 0.80A 3hjoB-5i33A:
undetectable		 3hjoB-5i33A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 8 ILE A 406
ALA A 399
VAL A 417
VAL A 414
 None
 0.75A 3me6B-5i33A:
undetectable		 3me6B-5i33A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 ASP A 234
GLY A 251
TYR A 237
 None
 0.75A 3w9tC-5i33A:
undetectable		 3w9tC-5i33A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 ASP A 234
GLY A 251
TYR A 237
 None
 0.74A 3w9tG-5i33A:
undetectable		 3w9tG-5i33A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 8 THR A 239
THR A 285
VAL A 319
VAL A 372
 None
 1.13A 4l4dA-5i33A:
undetectable		 4l4dA-5i33A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 ILE A 250
VAL A 253
LEU A 257
VAL A 223
LEU A  12
 None
 0.97A 4m11C-5i33A:
undetectable		 4m11C-5i33A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 TYR A 352
TYR A 376
PHE A 283
GLY A 351
THR A 275
 None
 1.34A 4mm4A-5i33A:
undetectable		 4mm4A-5i33A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 LEU A 257
ILE A 264
GLY A 251
VAL A  10
VAL A 267
 None
 1.15A 4nkvD-5i33A:
undetectable		 4nkvD-5i33A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 LEU A 257
GLY A 227
ASN A 327
ALA A 228
ASN A 229
 None
 1.31A 4pclB-5i33A:
2.9		 4pclB-5i33A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 5 GLY A  13
TYR A 322
SER A 323
GLU A  19
 None
 1.05A 4xueA-5i33A:
2.7		 4xueA-5i33A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 ASN A  43
ALA A 228
ARG A  37
 None
 0.72A 5cvtB-5i33A:
undetectable		 5cvtB-5i33A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 GLY A  40
HIS A 114
GLY A  79
ILE A  78
GLY A 251
 None
 0.95A 5d4uC-5i33A:
undetectable		 5d4uC-5i33A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 7 LEU A 317
THR A 275
THR A 276
LEU A 410
 None
 0.95A 5jq7B-5i33A:
undetectable		 5jq7B-5i33A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 8 GLY A  68
ARG A 423
VAL A  25
ASP A  26
 None
 0.87A 5vlmA-5i33A:
undetectable		 5vlmA-5i33A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 5 LEU A 340
LYS A 336
LEU A 295
GLU A 301
 None
 1.29A 5weaA-5i33A:
undetectable		 5weaA-5i33A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5i33 ADENYLOSUCCINATE
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 8 TYR A 402
THR A 335
TYR A 274
TRP A 382
 None
 1.32A 6cnjD-5i33A:
undetectable
6cnjE-5i33A:
undetectable		 6cnjD-5i33A:
11.63
6cnjE-5i33A:
11.82