SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i35'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR A 606
HIS A 559
ILE A 525
HIS A 610
 None
 0.84A 1ei6C-5i35A:
undetectable		 1ei6C-5i35A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR A 606
HIS A 559
ILE A 525
HIS A 610
 None
 1.00A 1ei6D-5i35A:
undetectable		 1ei6D-5i35A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 MET A 313
LEU A 316
ASN A 317
LEU A 320
GLY A 321
 None
 1.21A 1p93A-5i35A:
undetectable		 1p93A-5i35A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL A 364
TYR A 361
GLY A 363
TYR A 408
 None
 0.90A 1s1xA-5i35A:
undetectable		 1s1xA-5i35A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 300
LEU A 267
VAL A 270
GLY A 278
TYR A 408
 None
 1.17A 2cbrA-5i35A:
undetectable		 2cbrA-5i35A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 525
ILE A 526
ALA A 529
ALA A 562
ILE A 587
 None
 0.86A 2h79A-5i35A:
undetectable		 2h79A-5i35A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLU A 405
PRO A 489
MET A 485
GLY A 509
 None
 1.00A 2hs1B-5i35A:
undetectable		 2hs1B-5i35A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 525
ILE A 526
ALA A 529
ALA A 562
ILE A 587
 None
 0.88A 3gwsX-5i35A:
undetectable		 3gwsX-5i35A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ALA A 356
LYS A 358
GLU A 411
THR A 445
LEU A 447
LEU A 506
 ANP  A 700 ( 3.7A)
ANP  A 700 (-3.0A)
None
ANP  A 700 (-4.1A)
ANP  A 700 ( 4.5A)
ANP  A 700 ( 4.3A)
 0.85A 3hecA-5i35A:
7.4		 3hecA-5i35A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 ALA A 356
LYS A 358
GLU A 411
LEU A 443
LEU A 447
 ANP  A 700 ( 3.7A)
ANP  A 700 (-3.0A)
None
None
ANP  A 700 ( 4.5A)
 0.87A 3lfaA-5i35A:
4.0		 3lfaA-5i35A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		5 / 8 ALA A 356
LYS A 358
GLU A 411
THR A 445
LEU A 447
 ANP  A 700 ( 3.7A)
ANP  A 700 (-3.0A)
None
ANP  A 700 (-4.1A)
ANP  A 700 ( 4.5A)
 0.66A 3lfaA-5i35A:
4.0		 3lfaA-5i35A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A 606
HIS A 559
ILE A 525
HIS A 610
 None
 0.82A 3t01A-5i35A:
undetectable		 3t01A-5i35A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 525
ILE A 526
ALA A 529
ALA A 562
ILE A 587
 None
 0.74A 3uvvA-5i35A:
undetectable		 3uvvA-5i35A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLY A 342
ILE A 341
GLN A 360
SER A 340
 None
None
None
ANP  A 700 (-2.8A)
 1.06A 4kcnA-5i35A:
undetectable		 4kcnA-5i35A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 VAL A 344
ALA A 356
LYS A 358
GLU A 411
THR A 445
ASP A 507
 ANP  A 700 (-4.7A)
ANP  A 700 ( 3.7A)
ANP  A 700 (-3.0A)
None
ANP  A 700 (-4.1A)
ANP  A 700 (-2.8A)
 0.72A 4r7iA-5i35A:
7.4		 4r7iA-5i35A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA A 356
LYS A 358
THR A 445
LEU A 447
VAL A 448
 ANP  A 700 ( 3.7A)
ANP  A 700 (-3.0A)
ANP  A 700 (-4.1A)
ANP  A 700 ( 4.5A)
ANP  A 700 (-3.8A)
 0.68A 4rz7A-5i35A:
7.3		 4rz7A-5i35A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TRP A 324
ARG A 325
LEU A 309
 None
 0.57A 5dbyA-5i35A:
undetectable		 5dbyA-5i35A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 VAL A 344
ALA A 356
LYS A 358
GLU A 411
LEU A 443
THR A 445
 ANP  A 700 (-4.7A)
ANP  A 700 ( 3.7A)
ANP  A 700 (-3.0A)
None
None
ANP  A 700 (-4.1A)
 0.69A 5vcyA-5i35A:
9.8		 5vcyA-5i35A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU A 405
ALA A 339
GLY A 342
LEU A 275
ASP A 507
 None
ANP  A 700 (-3.1A)
None
None
ANP  A 700 (-2.8A)
 1.18A 5w7pA-5i35A:
undetectable		 5w7pA-5i35A:
20.49