SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i39'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
4 / 4 ALA A 311
GLN A 280
TYR A  97
LEU A 388
None
FAD  A 501 (-4.4A)
None
EDO  A 506 (-4.1A)
1.47A 1e6wC-5i39A:
0.2
1e6wC-5i39A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
4 / 8 PHE A 395
VAL A 294
GLY A 291
GLY A 292
None
0.90A 1ekjE-5i39A:
undetectable
1ekjF-5i39A:
undetectable
1ekjE-5i39A:
21.15
1ekjF-5i39A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
4 / 8 ALA A  89
GLY A  46
THR A 223
ILE A 221
None
0.64A 1gtnI-5i39A:
undetectable
1gtnJ-5i39A:
undetectable
1gtnI-5i39A:
11.39
1gtnJ-5i39A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 11 SER A  94
SER A  93
MET A 440
GLY A 439
GLY A 257
EDO  A 502 ( 3.9A)
FAD  A 501 (-2.5A)
FAD  A 501 (-4.2A)
FAD  A 501 (-3.2A)
FAD  A 501 (-3.4A)
1.42A 1jr1A-5i39A:
undetectable
1jr1A-5i39A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 9 GLY A 437
GLY A  63
LEU A  65
SER A  93
GLY A 257
EDO  A 507 ( 3.7A)
FAD  A 501 (-3.3A)
FAD  A 501 (-3.8A)
FAD  A 501 (-2.5A)
FAD  A 501 (-3.4A)
1.05A 1l4nA-5i39A:
undetectable
1l4nA-5i39A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_F_H4BF1005_1
(HYPOTHETICAL PROTEIN
PH0634)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 9 ILE A 420
ASP A 416
HIS A 113
THR A 436
GLU A 442
None
None
None
FAD  A 501 (-3.9A)
None
1.44A 2dttE-5i39A:
undetectable
2dttF-5i39A:
undetectable
2dttE-5i39A:
15.69
2dttF-5i39A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
3 / 3 ARG A 220
VAL A 252
THR A 249
None
0.60A 2nmzA-5i39A:
undetectable
2nmzA-5i39A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  98
GLY A 437
GLY A 439
THR A 436
ILE A 413
FAD  A 501 (-3.7A)
EDO  A 507 ( 3.7A)
FAD  A 501 (-3.2A)
FAD  A 501 (-3.9A)
EDO  A 507 ( 4.3A)
0.80A 2oxtA-5i39A:
undetectable
2oxtA-5i39A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  98
GLY A 437
GLY A 439
THR A 436
ILE A 413
FAD  A 501 (-3.7A)
EDO  A 507 ( 3.7A)
FAD  A 501 (-3.2A)
FAD  A 501 (-3.9A)
EDO  A 507 ( 4.3A)
0.76A 2oxtB-5i39A:
2.9
2oxtB-5i39A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
4 / 7 PHE A 201
ALA A 100
THR A 436
LEU A  65
None
None
FAD  A 501 (-3.9A)
FAD  A 501 (-3.8A)
0.87A 2wx2A-5i39A:
undetectable
2wx2A-5i39A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 VAL A  60
GLY A  61
GLY A  63
GLU A  84
ALA A 227
FAD  A 501 (-4.6A)
FAD  A 501 (-3.2A)
FAD  A 501 (-3.3A)
FAD  A 501 (-2.7A)
FAD  A 501 (-3.7A)
0.85A 3fuuA-5i39A:
4.4
3fuuA-5i39A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 VAL A  44
PHE A 208
LYS A 215
ILE A  67
VAL A 127
None
EDO  A 502 (-4.7A)
None
None
None
1.23A 3iw1A-5i39A:
undetectable
3iw1A-5i39A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
3 / 3 ARG A 220
VAL A 252
THR A 249
None
0.64A 3k4vD-5i39A:
undetectable
3k4vD-5i39A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
4 / 8 PHE A 201
ALA A 100
THR A 436
LEU A  65
None
None
FAD  A 501 (-3.9A)
FAD  A 501 (-3.8A)
0.91A 3khmA-5i39A:
undetectable
3khmA-5i39A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.89A 3p97C-5i39A:
2.8
3p97C-5i39A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.90A 4ctjC-5i39A:
undetectable
4ctjC-5i39A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.89A 4ctkA-5i39A:
undetectable
4ctkA-5i39A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.87A 4ctkC-5i39A:
undetectable
4ctkC-5i39A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
4 / 6 ARG A 121
GLY A 199
GLU A 195
MET A  68
None
1.32A 4g0vB-5i39A:
undetectable
4g0vB-5i39A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
4 / 6 LEU A 403
ILE A 283
LEU A 388
GLU A 389
None
None
EDO  A 506 (-4.1A)
EDO  A 506 (-3.6A)
0.97A 4w5nA-5i39A:
undetectable
4w5nA-5i39A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
4 / 4 LEU A 449
VAL A 445
GLU A 448
ARG A 119
None
1.39A 4ww7A-5i39A:
undetectable
4ww7A-5i39A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
4 / 6 ASP A 202
THR A 132
TYR A 133
SER A 200
None
1.49A 5b6iB-5i39A:
3.1
5b6iB-5i39A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
4 / 5 ARG A 138
GLY A 199
THR A 170
GLU A 195
None
1.20A 5btiC-5i39A:
undetectable
5btiD-5i39A:
undetectable
5btiC-5i39A:
21.41
5btiD-5i39A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.88A 5e9qA-5i39A:
2.8
5e9qA-5i39A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.88A 5ec8C-5i39A:
2.6
5ec8C-5i39A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.90A 5ehgA-5i39A:
2.8
5ehgA-5i39A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.88A 5ehgC-5i39A:
undetectable
5ehgC-5i39A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.88A 5eifA-5i39A:
2.7
5eifA-5i39A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.88A 5ekxB-5i39A:
undetectable
5ekxB-5i39A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
3 / 3 PRO A 465
ARG A 470
GLU A 108
None
0.86A 5j6hA-5i39A:
undetectable
5j6hA-5i39A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.93A 5kqrA-5i39A:
2.4
5kqrA-5i39A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.92A 5m5bA-5i39A:
2.5
5m5bA-5i39A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.87A 5vimA-5i39A:
2.4
5vimA-5i39A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.91A 5vimB-5i39A:
2.6
5vimB-5i39A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
4 / 7 GLY A 298
GLN A  99
TYR A  97
ASP A 144
None
1.12A 5vlmE-5i39A:
undetectable
5vlmE-5i39A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.85A 5wz1B-5i39A:
undetectable
5wz1B-5i39A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris)
5 / 12 GLY A  66
GLY A 257
GLY A  61
VAL A 271
ILE A 420
None
FAD  A 501 (-3.4A)
FAD  A 501 (-3.2A)
None
None
0.94A 5wz2C-5i39A:
2.5
5wz2C-5i39A:
24.29