SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		5 / 9 VAL A 291
GLY A 283
THR A 324
ILE A 284
THR A 140
 None
 1.28A 1gtnL-5i3eA:
undetectable
1gtnM-5i3eA:
undetectable		 1gtnL-5i3eA:
13.07
1gtnM-5i3eA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		4 / 5 LYS A 102
PHE A 200
LEU A 118
LEU A 160
 None
None
EDO  A 400 (-4.3A)
None
 1.39A 1skxA-5i3eA:
undetectable		 1skxA-5i3eA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		5 / 12 LEU A  15
LEU A 142
LEU A 118
LEU A 317
TYR A  41
 None
None
EDO  A 400 (-4.3A)
None
None
 0.94A 1sqnA-5i3eA:
undetectable		 1sqnA-5i3eA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		3 / 3 ALA A 311
VAL A 293
TRP A 282
 None
 0.81A 1tkqB-5i3eA:
undetectable		 1tkqB-5i3eA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		4 / 6 SER A  68
ILE A   3
ALA A 106
ALA A 125
 None
 0.95A 1w0gA-5i3eA:
undetectable		 1w0gA-5i3eA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		4 / 8 SER A 178
LEU A 180
LEU A 148
ASP A 175
 None
 0.89A 2j2pA-5i3eA:
undetectable
2j2pB-5i3eA:
undetectable		 2j2pA-5i3eA:
19.78
2j2pB-5i3eA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		4 / 7 LEU A 115
LEU A  81
ALA A 125
PHE A  70
 None
 0.93A 2vcvG-5i3eA:
undetectable		 2vcvG-5i3eA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		4 / 6 LEU A  24
THR A  25
LEU A 136
ASP A 278
 None
 1.13A 2wm3A-5i3eA:
undetectable		 2wm3A-5i3eA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		5 / 12 LEU A  15
LEU A 142
LEU A 118
LEU A 317
TYR A  41
 None
None
EDO  A 400 (-4.3A)
None
None
 1.01A 3d90A-5i3eA:
undetectable		 3d90A-5i3eA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		4 / 5 ASP A 108
ARG A 170
VAL A 104
THR A 184
 None
 1.16A 3eigA-5i3eA:
undetectable		 3eigA-5i3eA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		4 / 6 THR A 150
GLY A 152
ILE A 105
LEU A 148
 None
 1.04A 4acbC-5i3eA:
undetectable		 4acbC-5i3eA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		5 / 11 SER A 197
ILE A 211
TRP A 222
ASP A 295
GLY A 307
 None
None
None
EDO  A 400 (-2.7A)
EDO  A 400 ( 4.8A)
 1.41A 4foxH-5i3eA:
undetectable		 4foxH-5i3eA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		3 / 3 ALA A 311
TRP A 290
VAL A 291
 None
 0.31A 4w9nC-5i3eA:
undetectable		 4w9nC-5i3eA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		4 / 5 GLY A  60
TYR A  36
GLU A   8
ASP A  57
 None
 1.16A 4xueA-5i3eA:
undetectable		 4xueA-5i3eA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5i3e PUTATIVE
DEOXYRIBONUCLEASE-2
(Burkholderia
thailandensis) 		5 / 12 ALA A  33
PRO A 135
HIS A 279
GLY A 138
THR A 140
 None
 1.32A 5hfjB-5i3eA:
undetectable		 5hfjB-5i3eA:
19.89