SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		5 / 10 GLY A 131
ALA A 132
VAL A 189
GLY A 135
ILE A 215
 None
 0.90A 1muiA-5i3sA:
undetectable		 1muiA-5i3sA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		4 / 6 ILE A 239
VAL A  62
ILE A 104
ILE A  53
 None
 0.74A 1uwhA-5i3sA:
undetectable		 1uwhA-5i3sA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		4 / 8 TYR A 181
TYR A 124
ARG A 134
VAL A 115
 None
 0.63A 2fl5E-5i3sA:
undetectable
2fl5F-5i3sA:
undetectable		 2fl5E-5i3sA:
19.15
2fl5F-5i3sA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		4 / 6 HIS A 266
PHE A 209
GLN A 205
PRO A 206
 None
 1.11A 2qqtA-5i3sA:
undetectable		 2qqtA-5i3sA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		4 / 6 HIS A 266
PHE A 209
GLN A 205
PRO A 206
 None
 1.12A 3gclA-5i3sA:
undetectable		 3gclA-5i3sA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		5 / 10 LEU A 240
ASN A 225
GLN A 222
LEU A 216
LEU A 231
 None
 1.24A 3h52B-5i3sA:
undetectable		 3h52B-5i3sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		3 / 3 TYR A 133
LEU A 196
ARG A 134
 None
 0.69A 3sufB-5i3sA:
undetectable		 3sufB-5i3sA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		5 / 12 GLY A 242
ALA A 198
ILE A 154
ILE A 239
ILE A 250
 None
 0.97A 3tkgC-5i3sA:
undetectable		 3tkgC-5i3sA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		4 / 7 ILE A  85
PRO A  84
GLY A  67
GLU A  66
 None
 0.69A 4g0uB-5i3sA:
undetectable		 4g0uB-5i3sA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASP A  83
ASP A 208
ASP A  86
GLU A 187
 None
None
None
PO4  A 301 (-2.7A)
 1.02A 4xjeA-5i3sA:
undetectable		 4xjeA-5i3sA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASP A 208
ASP A  86
ASP A  83
ILE A  18
 None
 0.93A 4xjeA-5i3sA:
undetectable		 4xjeA-5i3sA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASP A  83
ASP A 208
ASP A  86
GLU A 187
 None
None
None
PO4  A 301 (-2.7A)
 0.97A 5cfsA-5i3sA:
undetectable		 5cfsA-5i3sA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		4 / 8 ASP A 208
ASP A  86
ASP A  83
ILE A  18
 None
 0.95A 5cfsA-5i3sA:
undetectable		 5cfsA-5i3sA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN
(Staphylococcus
aureus) 		5 / 12 LEU A 213
THR A  74
ALA A 184
LEU A  63
LEU A 204
 None
None
PO4  A 301 ( 4.8A)
None
None
 1.20A 6ie8A-5i3sA:
undetectable		 6ie8A-5i3sA:
22.14