SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i45'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 5i45 GLYCOSYL
TRANSFERASES GROUP 1
FAMILY PROTEIN
(Francisella
tularensis) 		6 / 12 GLY A 167
LEU A 248
VAL A 252
LEU A 307
ALA A 187
PHE A 183
 None
 1.30A 1gseB-5i45A:
undetectable		 1gseB-5i45A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5i45 GLYCOSYL
TRANSFERASES GROUP 1
FAMILY PROTEIN
(Francisella
tularensis) 		5 / 12 ILE A 170
GLY A 280
ALA A 279
SER A 255
GLY A 179
 None
 0.96A 3hs6B-5i45A:
undetectable		 3hs6B-5i45A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 5i45 GLYCOSYL
TRANSFERASES GROUP 1
FAMILY PROTEIN
(Francisella
tularensis) 		5 / 10 ALA A 276
ILE A 285
GLY A 261
ALA A 267
VAL A 274
 None
 1.04A 3t3cB-5i45A:
undetectable		 3t3cB-5i45A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5i45 GLYCOSYL
TRANSFERASES GROUP 1
FAMILY PROTEIN
(Francisella
tularensis) 		5 / 12 ILE A 170
GLY A 280
ALA A 279
SER A 255
GLY A 179
 None
 1.08A 4e1gB-5i45A:
undetectable		 4e1gB-5i45A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5i45 GLYCOSYL
TRANSFERASES GROUP 1
FAMILY PROTEIN
(Francisella
tularensis) 		4 / 8 GLY A 167
ILE A 250
ARG A 317
ILE A 311
 None
 0.84A 4em2A-5i45A:
undetectable		 4em2A-5i45A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5i45 GLYCOSYL
TRANSFERASES GROUP 1
FAMILY PROTEIN
(Francisella
tularensis) 		5 / 9 LEU A 191
THR A 190
LEU A 307
ILE A 250
LEU A 310
 None
 1.38A 5g48B-5i45A:
undetectable		 5g48B-5i45A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5i45 GLYCOSYL
TRANSFERASES GROUP 1
FAMILY PROTEIN
(Francisella
tularensis) 		5 / 12 ALA A 187
HIS A 256
GLY A 179
SER A 255
SER A 300
 None
 1.27A 5hfjB-5i45A:
2.6		 5hfjB-5i45A:
21.46