SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		5 / 12 VAL A 234
LEU A 180
TYR A 232
ILE A 224
LEU A  96
 None
 1.04A 1cqeA-5i47A:
undetectable		 1cqeA-5i47A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		5 / 12 VAL A 234
LEU A 180
TYR A 232
ILE A 224
LEU A  96
 None
 1.04A 1cqeB-5i47A:
undetectable		 1cqeB-5i47A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		5 / 12 VAL A 234
LEU A 180
TYR A 232
ILE A 224
LEU A  96
 None
 1.09A 2aylB-5i47A:
undetectable		 2aylB-5i47A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		3 / 3 ARG A 222
ASP A 241
GLN A 168
 None
 0.91A 3lcvB-5i47A:
undetectable		 3lcvB-5i47A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		5 / 12 ILE A 268
ALA A 265
GLY A 274
GLY A 230
VAL A  77
 None
 1.10A 5i75A-5i47A:
undetectable		 5i75A-5i47A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		5 / 12 ARG A  25
VAL A   4
LEU A   6
ALA A 269
LEU A 273
 None
 1.10A 5jvzA-5i47A:
undetectable		 5jvzA-5i47A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		5 / 12 ARG A  25
VAL A   4
LEU A   6
ALA A 269
LEU A 273
 None
 1.09A 5jvzB-5i47A:
undetectable		 5jvzB-5i47A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		4 / 7 VAL A 264
ARG A 255
GLU A  14
ARG A 179
 None
 1.12A 5umwB-5i47A:
undetectable
5umwE-5i47A:
undetectable		 5umwB-5i47A:
15.94
5umwE-5i47A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		4 / 8 LEU A 180
VAL A 234
VAL A 236
ILE A 101
 None
 0.71A 5y9mX-5i47A:
undetectable		 5y9mX-5i47A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		3 / 3 ARG A  12
PHE A 254
ARG A  55
 None
 1.05A 5y9yA-5i47A:
undetectable		 5y9yA-5i47A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		3 / 3 ARG A  55
ARG A 179
ARG A 255
 None
 1.09A 6bplA-5i47A:
undetectable
6bplB-5i47A:
undetectable		 6bplA-5i47A:
15.87
6bplB-5i47A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		4 / 4 ALA A  63
ALA A  66
ALA A  83
ALA A  87
 None
 0.84A 6gtqA-5i47A:
undetectable
6gtqB-5i47A:
undetectable		 6gtqA-5i47A:
22.97
6gtqB-5i47A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		4 / 4 ALA A  66
ALA A  70
ALA A  80
ALA A  83
 None
 0.85A 6gtqA-5i47A:
undetectable
6gtqB-5i47A:
undetectable		 6gtqA-5i47A:
22.97
6gtqB-5i47A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		4 / 4 ALA A  80
ALA A  83
ALA A  66
ALA A  70
 None
 0.85A 6gtqA-5i47A:
undetectable
6gtqB-5i47A:
undetectable		 6gtqA-5i47A:
22.97
6gtqB-5i47A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5i47 RIMK DOMAIN PROTEIN
ATP-GRASP
(Sphaerobacter
thermophilus) 		4 / 4 ALA A  83
ALA A  87
ALA A  63
ALA A  66
 None
 0.85A 6gtqA-5i47A:
undetectable
6gtqB-5i47A:
undetectable		 6gtqA-5i47A:
22.97
6gtqB-5i47A:
22.97