SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 6 SER A 144
GLY A 578
THR A 546
ILE A 567
 None
 0.93A 1gtnD-5i4aA:
undetectable
1gtnE-5i4aA:
undetectable		 1gtnD-5i4aA:
7.50
1gtnE-5i4aA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		5 / 12 ILE A 488
LEU A 489
GLY A 473
GLU A 492
ILE A 445
 None
 1.26A 1kyvC-5i4aA:
undetectable
1kyvD-5i4aA:
3.3		 1kyvC-5i4aA:
11.02
1kyvD-5i4aA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		5 / 12 ILE A 488
LEU A 489
GLY A 473
GLU A 492
ILE A 445
 None
 1.27A 1kyvD-5i4aA:
3.5
1kyvE-5i4aA:
5.0		 1kyvD-5i4aA:
11.02
1kyvE-5i4aA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 6 GLY A 233
PRO A 238
LYS A 239
THR A 240
 None
 1.24A 2m2oB-5i4aA:
undetectable		 2m2oB-5i4aA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 6 LEU A   5
TYR A 254
ILE A 567
ILE A 137
 None
 1.00A 2q8hA-5i4aA:
undetectable		 2q8hA-5i4aA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 8 ILE A  92
LEU A 250
ILE A 132
PHE A  96
 None
 0.68A 2w9sE-5i4aA:
undetectable		 2w9sE-5i4aA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 5 LYS A 236
THR A 240
PHE A 101
LEU A 128
 None
 1.37A 3tf1A-5i4aA:
undetectable		 3tf1A-5i4aA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 6 SER A 448
LEU A 458
HIS A 475
THR A 456
 None
 1.48A 3thrB-5i4aA:
undetectable		 3thrB-5i4aA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		3 / 3 LYS A  71
GLU A  73
TRP A  49
 None
 0.92A 3v4tH-5i4aA:
undetectable		 3v4tH-5i4aA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 7 THR A 603
HIS A 607
TYR A 268
TYR A 600
 None
 1.33A 4a3uA-5i4aA:
undetectable		 4a3uA-5i4aA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 7 THR A 603
HIS A 607
TYR A 268
TYR A 600
 None
 1.35A 4a3uB-5i4aA:
undetectable		 4a3uB-5i4aA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 8 ASP A 630
ASP A 446
ASP A 516
GLU A 632
 None
None
None
U  B   1 ( 3.8A)
 1.05A 4feuD-5i4aA:
undetectable		 4feuD-5i4aA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 6 TYR A 442
TYR A 500
LEU A 470
PHE A 504
 None
 1.12A 4twdB-5i4aA:
undetectable
4twdC-5i4aA:
undetectable		 4twdB-5i4aA:
16.49
4twdC-5i4aA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 6 TYR A 442
TYR A 500
LEU A 470
PHE A 504
 None
 1.16A 4twdD-5i4aA:
undetectable
4twdE-5i4aA:
undetectable		 4twdD-5i4aA:
16.49
4twdE-5i4aA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 6 TYR A 442
TYR A 500
LEU A 470
PHE A 504
 None
 1.23A 4twdF-5i4aA:
undetectable
4twdG-5i4aA:
undetectable		 4twdF-5i4aA:
16.49
4twdG-5i4aA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 8 TYR A 216
ASP A 212
TYR A 166
THR A 209
 None
None
A  B   7 ( 4.1A)
A  B   7 ( 3.0A)
 1.03A 5ov9B-5i4aA:
undetectable		 5ov9B-5i4aA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 6 ILE A 137
ILE A  92
LEU A  88
PHE A 243
 None
 0.98A 5vkqA-5i4aA:
undetectable
5vkqB-5i4aA:
undetectable		 5vkqA-5i4aA:
15.92
5vkqB-5i4aA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5i4a ARGONAUTE PROTEIN
(Marinitoga
piezophila) 		4 / 6 PHE A 243
ILE A 137
ILE A  92
LEU A  88
 None
 0.97A 5vkqA-5i4aA:
undetectable
5vkqD-5i4aA:
undetectable		 5vkqA-5i4aA:
15.92
5vkqD-5i4aA:
15.92