SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB
(Escherichia
coli) 		5 / 9 LEU A  23
ILE A  19
LEU A 123
VAL A 107
ALA A 112
 None
 0.99A 1e7aA-5i4cA:
undetectable		 1e7aA-5i4cA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB
(Escherichia
coli) 		5 / 12 ILE A  19
VAL A   6
VAL A 107
ALA A 119
ILE A 103
 None
 1.00A 1epbA-5i4cA:
undetectable		 1epbA-5i4cA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB
(Escherichia
coli) 		5 / 12 ILE A  19
VAL A   6
VAL A 107
ALA A 119
ILE A 103
 None
 1.00A 1epbB-5i4cA:
undetectable		 1epbB-5i4cA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB
(Escherichia
coli) 		5 / 12 LEU A  81
ILE A  71
MET A  59
SER A  38
ILE A   7
 None
 1.23A 1xotA-5i4cA:
undetectable		 1xotA-5i4cA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB
(Escherichia
coli) 		5 / 11 ILE A  68
GLY A  67
LYS A  72
SER A  38
LEU A 101
 None
 1.30A 3iluB-5i4cA:
undetectable
3iluE-5i4cA:
undetectable		 3iluB-5i4cA:
21.63
3iluE-5i4cA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB
(Escherichia
coli) 		5 / 9 GLU A 104
LEU A  70
VAL A  98
LEU A 101
ILE A  68
 None
 1.19A 4r38C-5i4cA:
undetectable		 4r38C-5i4cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB
(Escherichia
coli) 		5 / 10 ILE A   7
ILE A   8
LEU A  16
ILE A  42
ASN A  43
 None
 1.43A 5vkqA-5i4cA:
undetectable
5vkqD-5i4cA:
undetectable		 5vkqA-5i4cA:
6.20
5vkqD-5i4cA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB
(Escherichia
coli) 		5 / 10 ILE A  42
ASN A  43
ILE A   7
ILE A   8
LEU A  16
 None
 1.43A 5vkqA-5i4cA:
undetectable
5vkqB-5i4cA:
undetectable		 5vkqA-5i4cA:
6.20
5vkqB-5i4cA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB
(Escherichia
coli) 		5 / 10 ILE A  42
ASN A  43
ILE A   7
ILE A   8
LEU A  16
 None
 1.43A 5vkqC-5i4cA:
undetectable
5vkqD-5i4cA:
undetectable		 5vkqC-5i4cA:
6.20
5vkqD-5i4cA:
6.20