SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		3 / 3 MET A 682
LEU A 685
SER A 686
 None
 0.67A 1ee2A-5i4eA:
undetectable		 1ee2A-5i4eA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 9 LEU A 451
LEU A 459
GLU A 361
ILE A 244
PHE A 262
 None
 1.34A 1gx8A-5i4eA:
undetectable		 1gx8A-5i4eA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		3 / 3 ARG A 632
ILE A 637
TRP A 454
 None
 1.23A 1m8eB-5i4eA:
undetectable		 1m8eB-5i4eA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 8 GLN A 583
PHE A 594
ASN A 488
ASP A 604
 None
 1.34A 1p6kA-5i4eA:
undetectable		 1p6kA-5i4eA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 6 LEU A 554
TRP A 610
LEU A 493
PHE A 594
 None
 1.44A 1ru9H-5i4eA:
undetectable
1ru9L-5i4eA:
undetectable		 1ru9H-5i4eA:
11.90
1ru9L-5i4eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 6 LEU A 554
TRP A 610
LEU A 493
PHE A 594
 None
 1.47A 1rukH-5i4eA:
undetectable
1rukL-5i4eA:
undetectable		 1rukH-5i4eA:
11.90
1rukL-5i4eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 12 LEU A 681
LEU A 678
ILE A 476
THR A 208
LEU A 505
 None
 1.09A 1tw4A-5i4eA:
undetectable		 1tw4A-5i4eA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 8 GLN A 583
PHE A 594
ASN A 488
ASP A 604
 None
 1.35A 1zzqA-5i4eA:
undetectable		 1zzqA-5i4eA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 8 GLN A 583
PHE A 594
ASN A 488
ASP A 604
 None
 1.31A 1zzuA-5i4eA:
undetectable		 1zzuA-5i4eA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 11 ARG A 267
PHE A 270
GLY A 470
GLN A 192
GLU A 190
 None
 1.39A 2dyrG-5i4eA:
undetectable
2dyrN-5i4eA:
0.0
2dyrO-5i4eA:
undetectable		 2dyrG-5i4eA:
6.43
2dyrN-5i4eA:
18.49
2dyrO-5i4eA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 11 ARG A 267
PHE A 270
GLY A 470
GLN A 192
GLU A 190
 None
 1.36A 2eimG-5i4eA:
undetectable
2eimN-5i4eA:
2.4
2eimO-5i4eA:
undetectable		 2eimG-5i4eA:
6.43
2eimN-5i4eA:
18.49
2eimO-5i4eA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 12 PHE A 438
ALA A 442
ALA A 291
ARG A 290
GLU A 287
 None
 1.01A 2j0dA-5i4eA:
undetectable		 2j0dA-5i4eA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		5 / 11 LEU A 815
VAL A 816
SER A 861
ILE A 893
ALA A 899
 None
 1.07A 2zbzA-5i4eA:
undetectable		 2zbzA-5i4eA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_G_CHDG86_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 11 ARG A 267
PHE A 270
GLY A 470
GLN A 192
GLU A 190
 None
 1.39A 2zxwG-5i4eA:
undetectable
2zxwN-5i4eA:
0.0
2zxwO-5i4eA:
5.0		 2zxwG-5i4eA:
6.43
2zxwN-5i4eA:
18.49
2zxwO-5i4eA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		4 / 7 ILE A 637
ILE A 292
LEU A 633
LEU A 400
 None
 0.85A 3adxA-5i4eA:
undetectable		 3adxA-5i4eA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		3 / 3 TYR A 148
TYR A 129
ILE A 145
 AOV  A1500 (-4.4A)
None
None
 0.76A 3eteA-5i4eA:
undetectable
3eteB-5i4eA:
0.8		 3eteA-5i4eA:
19.17
3eteB-5i4eA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 4 LEU A 888
PRO A 885
LEU A 809
ARG A 811
 None
 1.20A 3hcoB-5i4eA:
undetectable		 3hcoB-5i4eA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 8 GLN A 583
PHE A 594
ASN A 488
ASP A 604
 None
 1.30A 3n62A-5i4eA:
undetectable		 3n62A-5i4eA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		4 / 7 LEU A 716
GLN A 503
PHE A 506
LEU A 532
 None
 0.93A 3qeoB-5i4eA:
1.9		 3qeoB-5i4eA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		3 / 3 THR A 386
ASN A 385
GLU A 383
 None
 0.58A 3v4tA-5i4eA:
undetectable
3v4tC-5i4eA:
undetectable		 3v4tA-5i4eA:
19.16
3v4tC-5i4eA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 6 GLU A 206
ASP A 478
ASP A 257
ASN A 250
 AOV  A1500 (-4.2A)
MG  A1501 ( 4.6A)
None
None
 1.24A 3vywA-5i4eA:
undetectable		 3vywA-5i4eA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 5 GLU A 206
ASP A 478
ASP A 257
ASN A 250
 AOV  A1500 (-4.2A)
MG  A1501 ( 4.6A)
None
None
 1.24A 3vywD-5i4eA:
undetectable		 3vywD-5i4eA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		4 / 5 GLU A 199
GLY A 198
TYR A 599
GLN A 503
 None
 1.44A 3w9tE-5i4eA:
undetectable		 3w9tE-5i4eA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		3 / 3 GLU A 235
GLY A 232
SER A 220
 None
 0.66A 4b53B-5i4eA:
undetectable		 4b53B-5i4eA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		4 / 6 PHE A 411
ASN A 619
ALA A 439
LEU A 380
 None
 0.85A 4ejgD-5i4eA:
undetectable		 4ejgD-5i4eA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 7 GLN A 583
PHE A 594
ASN A 488
ASP A 604
 None
 1.36A 4kcnB-5i4eA:
undetectable		 4kcnB-5i4eA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 5 VAL A 596
LEU A 550
VAL A 572
PHE A 594
 None
 1.02A 4lb0B-5i4eA:
undetectable		 4lb0B-5i4eA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		3 / 4 ARG A 225
GLY A 232
GLU A 235
 None
 0.64A 4z2dB-5i4eA:
undetectable
4z2dC-5i4eA:
undetectable		 4z2dB-5i4eA:
20.06
4z2dC-5i4eA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		5 / 10 PHE A 248
ALA A 247
VAL A 369
LEU A 319
PHE A 345
 None
 1.29A 4zmeB-5i4eA:
undetectable		 4zmeB-5i4eA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 5 LEU A 771
PHE A 787
ILE A 768
ILE A 785
 None
 0.99A 5dzk4-5i4eA:
undetectable
5dzkg-5i4eA:
undetectable
5dzkm-5i4eA:
undetectable
5dzkn-5i4eA:
undetectable		 5dzk4-5i4eA:
1.04
5dzkg-5i4eA:
13.87
5dzkm-5i4eA:
11.46
5dzkn-5i4eA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 6 ILE A 194
ALA A 176
THR A 178
VAL A 693
HIS A 173
 None
 1.31A 5eclD-5i4eA:
undetectable		 5eclD-5i4eA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		5 / 9 GLN A 583
GLY A 601
GLU A 500
ASN A 496
ILE A 484
 None
 1.36A 5entC-5i4eA:
undetectable		 5entC-5i4eA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		5 / 12 PHE A 485
TYR A 599
ILE A 479
GLY A 481
ILE A 495
 None
None
None
AOV  A1500 (-3.0A)
None
 1.18A 5ifuA-5i4eA:
undetectable		 5ifuA-5i4eA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		4 / 8 LEU A 380
ILE A 378
ALA A 397
PHE A 411
 None
 0.98A 5m0oC-5i4eA:
undetectable		 5m0oC-5i4eA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		5 / 10 VAL A 641
LEU A 625
ALA A 624
THR A 417
GLY A 646
 None
 1.26A 5m5cE-5i4eA:
undetectable		 5m5cE-5i4eA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 12 ILE A 276
GLY A 278
PHE A 473
TYR A 182
ALA A 219
 None
 1.08A 5n0oA-5i4eA:
2.2		 5n0oA-5i4eA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 12 ILE A 276
GLY A 278
PHE A 473
TYR A 182
ALA A 219
 None
 1.09A 5n0oB-5i4eA:
2.3		 5n0oB-5i4eA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 12 ILE A 276
GLY A 278
PHE A 473
TYR A 182
ALA A 219
 None
 1.09A 5n0rA-5i4eA:
2.0		 5n0rA-5i4eA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 12 ILE A 276
GLY A 278
PHE A 473
TYR A 182
ALA A 219
 None
 1.10A 5n0sA-5i4eA:
1.8		 5n0sA-5i4eA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 12 ILE A 276
GLY A 278
PHE A 473
TYR A 182
ALA A 219
 None
 1.09A 5n0tA-5i4eA:
2.3		 5n0tA-5i4eA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 12 ILE A 276
GLY A 278
PHE A 473
TYR A 182
ALA A 219
 None
 1.10A 5n0wA-5i4eA:
1.9		 5n0wA-5i4eA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 12 ILE A 276
GLY A 278
PHE A 473
TYR A 182
ALA A 219
 None
 1.08A 5n0xA-5i4eA:
1.9		 5n0xA-5i4eA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 12 ILE A 276
GLY A 278
PHE A 473
TYR A 182
ALA A 219
 None
 1.08A 5n0xB-5i4eA:
1.8		 5n0xB-5i4eA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 12 ILE A 276
GLY A 278
PHE A 473
TYR A 182
ALA A 219
 None
 1.10A 5n4iA-5i4eA:
undetectable		 5n4iA-5i4eA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		5 / 12 LEU A 463
ALA A 241
ILE A 268
ALA A 279
ILE A 476
 None
 0.98A 5nm5B-5i4eA:
undetectable		 5nm5B-5i4eA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 5 GLU A 609
GLU A 434
GLU A 441
PHE A 438
 None
 1.01A 5onlA-5i4eA:
undetectable		 5onlA-5i4eA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 8 GLN A 583
PHE A 594
ASN A 488
ASP A 604
 None
 1.31A 5vunA-5i4eA:
undetectable		 5vunA-5i4eA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		5 / 12 LEU A 239
LEU A 463
ILE A 268
ALA A 279
ILE A 476
 None
 1.19A 5xiwD-5i4eA:
undetectable		 5xiwD-5i4eA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 12 PHE A 741
ILE A 785
VAL A 780
VAL A 791
PHE A 787
 None
 1.20A 6ap6A-5i4eA:
undetectable		 6ap6A-5i4eA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		5 / 12 PHE A 741
ILE A 785
VAL A 780
VAL A 791
PHE A 787
 None
 1.20A 6ap6B-5i4eA:
undetectable		 6ap6B-5i4eA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		5 / 12 GLN A 150
LEU A 151
PRO A 152
ILE A 134
VAL A 144
 None
 1.16A 6debB-5i4eA:
undetectable		 6debB-5i4eA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 7 ALA A 181
ASP A 478
ILE A 476
ILE A 212
 None
MG  A1501 ( 4.6A)
None
None
 0.98A 6fbnA-5i4eA:
undetectable		 6fbnA-5i4eA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 5 LEU A 626
THR A 634
THR A 630
GLY A 405
 None
 1.27A 6gtqA-5i4eA:
undetectable		 6gtqA-5i4eA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 5 GLU A 609
GLU A 434
GLU A 441
PHE A 438
 None
 1.01A 6hrjA-5i4eA:
undetectable		 6hrjA-5i4eA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		3 / 3 ASN A 619
PRO A 418
GLN A 428
 None
 0.88A 6jnhA-5i4eA:
undetectable		 6jnhA-5i4eA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		3 / 3 ASN A 619
PRO A 418
GLN A 428
 None
 0.92A 6jogA-5i4eA:
undetectable		 6jogA-5i4eA:
11.11