SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i4h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 5i4h CATHEPSIN L1
CATHEPSIN L1
(Homo
sapiens;
Homo
sapiens) 		7 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS B 163
 None
 0.25A 1stfE-5i4hA:
12.2
1stfI-5i4hA:
undetectable		 1stfE-5i4hA:
31.84
1stfI-5i4hA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5i4h CATHEPSIN L1
CATHEPSIN L1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE B 211
ALA B 125
THR B 128
ALA A   1
ARG A   3
 None
 1.19A 2j0dA-5i4hB:
undetectable		 2j0dA-5i4hB:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 5i4h CATHEPSIN L1
(Homo
sapiens) 		5 / 10 SER A  57
ALA A  73
ASN A  62
ALA A  27
TYR A  76
 None
 1.43A 2r2vC-5i4hA:
undetectable
2r2vF-5i4hA:
undetectable
2r2vG-5i4hA:
undetectable		 2r2vC-5i4hA:
13.64
2r2vF-5i4hA:
13.64
2r2vG-5i4hA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 5i4h CATHEPSIN L1
(Homo
sapiens) 		4 / 7 GLN A  19
GLY A  23
HIS B 163
TRP B 189
 None
 0.37A 3ai8A-5i4hA:
8.8		 3ai8A-5i4hA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 5i4h CATHEPSIN L1
(Homo
sapiens) 		3 / 3 LEU A  69
ASP A  71
TYR A  72
 None
 0.56A 4qc6B-5i4hA:
undetectable		 4qc6B-5i4hA:
15.30