SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		5 / 12 HIS A  67
GLY A 207
HIS A 140
ASP A 281
ASP A  65
 MN  A 501 (-3.4A)
None
MN  A 501 (-3.3A)
MN  A 501 (-2.0A)
None
 1.26A 1a4lD-5i4kA:
undetectable		 1a4lD-5i4kA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		4 / 8 LEU A 308
HIS A 305
ASP A 194
LEU A 195
 None
 1.05A 1e7cA-5i4kA:
undetectable		 1e7cA-5i4kA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		5 / 11 TYR A 151
ILE A  45
MET A 296
LEU A 145
ASP A 138
 None
 1.35A 1mrlA-5i4kA:
undetectable
1mrlB-5i4kA:
undetectable		 1mrlA-5i4kA:
20.32
1mrlB-5i4kA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		3 / 3 ASP A 100
THR A  94
GLU A 136
 None
 0.88A 1pj7A-5i4kA:
2.0		 1pj7A-5i4kA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		4 / 8 TYR A 177
LEU A 181
ASP A 185
THR A 292
 None
None
None
MN  A 502 ( 4.7A)
 1.04A 1rmtD-5i4kA:
undetectable		 1rmtD-5i4kA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		4 / 7 LEU A 184
ASN A  48
ILE A  45
ASP A  44
 None
 0.98A 1yc2E-5i4kA:
undetectable		 1yc2E-5i4kA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		5 / 12 ALA A 284
ALA A 208
ILE A  41
PHE A 209
LEU A 145
 None
MN  A 501 ( 4.6A)
None
None
None
 1.00A 2nyrA-5i4kA:
undetectable		 2nyrA-5i4kA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		5 / 12 HIS A  67
GLY A 207
HIS A 140
SER A 257
ASP A 281
 MN  A 501 (-3.4A)
None
MN  A 501 (-3.3A)
None
MN  A 501 (-2.0A)
 1.30A 2pgfA-5i4kA:
undetectable		 2pgfA-5i4kA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		5 / 12 HIS A  67
ILE A 226
GLY A 207
HIS A 140
ASP A 281
 MN  A 501 (-3.4A)
None
None
MN  A 501 (-3.3A)
MN  A 501 (-2.0A)
 1.23A 2pgfA-5i4kA:
undetectable		 2pgfA-5i4kA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		4 / 6 ILE A 304
PHE A 275
ALA A 276
ASN A 251
 None
 1.05A 3pgyA-5i4kA:
undetectable
3pgyB-5i4kA:
undetectable		 3pgyA-5i4kA:
24.01
3pgyB-5i4kA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		4 / 7 TYR A  39
ASN A  88
ILE A  41
MET A 297
 None
 1.27A 3tvxB-5i4kA:
undetectable		 3tvxB-5i4kA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		4 / 6 HIS A 140
GLU A 255
ASP A 281
SER A 257
 MN  A 501 (-3.3A)
None
MN  A 501 (-2.0A)
None
 1.10A 4apjA-5i4kA:
undetectable
4apjP-5i4kA:
undetectable		 4apjA-5i4kA:
18.49
4apjP-5i4kA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		5 / 12 GLU A 255
ASP A 138
GLY A 207
SER A 205
GLN A 231
 None
 1.15A 4djeB-5i4kA:
undetectable		 4djeB-5i4kA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		5 / 12 GLU A 255
ASP A 281
ASP A 138
GLY A 207
SER A 205
 None
MN  A 501 (-2.0A)
None
None
None
 1.23A 4djeB-5i4kA:
undetectable		 4djeB-5i4kA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		5 / 12 GLU A 255
ASP A 281
LEU A 128
GLY A 207
SER A 205
 None
MN  A 501 (-2.0A)
None
None
None
 1.30A 4djfB-5i4kA:
undetectable		 4djfB-5i4kA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		4 / 7 HIS A  67
PRO A  66
ASP A  65
ASP A 281
 MN  A 501 (-3.4A)
None
None
MN  A 501 (-2.0A)
 1.22A 4odjA-5i4kA:
undetectable		 4odjA-5i4kA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		4 / 6 TYR A 151
GLU A  93
THR A  38
LEU A  42
 None
 1.39A 4qztA-5i4kA:
undetectable		 4qztA-5i4kA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		3 / 3 ASP A 194
ASN A 198
GLN A 199
 None
 0.76A 5k7uA-5i4kA:
undetectable		 5k7uA-5i4kA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		4 / 6 PHE A  99
ASN A  88
LEU A  92
GLY A  95
 None
 0.99A 5o4yA-5i4kA:
undetectable		 5o4yA-5i4kA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5i4k MANGANESE-BINDING
LIPOPROTEIN MNTA
(Listeria
monocytogenes) 		4 / 8 HIS A  67
PRO A  66
ASP A  65
ASP A 281
 MN  A 501 (-3.4A)
None
None
MN  A 501 (-2.0A)
 1.23A 5t8sB-5i4kA:
undetectable		 5t8sB-5i4kA:
23.95