SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i4q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 5i4q CONTACT-DEPENDENT
INHIBITOR A
(Escherichia
coli) 		5 / 9 LEU A 235
LEU A 195
ARG A 200
VAL A 246
GLY A 247
 None
 1.10A 1e7aA-5i4qA:
undetectable		 1e7aA-5i4qA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 5i4q CONTACT-DEPENDENT
INHIBITOR A
(Escherichia
coli) 		5 / 9 LEU A 235
LEU A 195
ARG A 200
VAL A 246
GLY A 247
 None
 1.20A 1e7aB-5i4qA:
undetectable		 1e7aB-5i4qA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5i4q ELONGATION FACTOR TU
(Escherichia
coli) 		4 / 7 VAL C 309
GLY C 387
ILE C 342
VAL C 361
 None
 0.76A 1p2yA-5i4qC:
undetectable		 1p2yA-5i4qC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5i4q CONTACT-DEPENDENT
INHIBITOR I
ELONGATION FACTOR TU
(Escherichia
coli) 		3 / 3 THR C 341
GLU B   6
HIS C 365
 None
 0.64A 1xwfA-5i4qC:
undetectable		 1xwfA-5i4qC:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5i4q CONTACT-DEPENDENT
INHIBITOR I
ELONGATION FACTOR TU
(Escherichia
coli) 		3 / 3 THR C 341
GLU B   6
HIS C 365
 None
 0.61A 1xwfB-5i4qC:
undetectable		 1xwfB-5i4qC:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5i4q CONTACT-DEPENDENT
INHIBITOR I
ELONGATION FACTOR TU
(Escherichia
coli) 		3 / 3 THR C 341
GLU B   6
HIS C 365
 None
 0.63A 1xwfC-5i4qC:
undetectable		 1xwfC-5i4qC:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5i4q CONTACT-DEPENDENT
INHIBITOR I
ELONGATION FACTOR TU
(Escherichia
coli) 		3 / 3 THR C 341
GLU B   6
HIS C 365
 None
 0.60A 1xwfD-5i4qC:
undetectable		 1xwfD-5i4qC:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5i4q CONTACT-DEPENDENT
INHIBITOR I
(Escherichia
coli) 		4 / 7 GLY B  40
THR B  42
PHE B  51
PHE B  55
 None
 1.17A 2qx4A-5i4qB:
undetectable
2qx4B-5i4qB:
undetectable		 2qx4A-5i4qB:
18.26
2qx4B-5i4qB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5i4q CONTACT-DEPENDENT
INHIBITOR I
(Escherichia
coli) 		3 / 3 TYR B  89
GLN B  48
TRP B  94
 None
 1.17A 4kn2C-5i4qB:
undetectable		 4kn2C-5i4qB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_I_MTXI301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5i4q ELONGATION FACTOR TU
(Escherichia
coli) 		5 / 9 PHE C 375
GLY C 318
GLY C 385
LEU C 312
GLU C 316
 None
 1.17A 4l8wI-5i4qC:
undetectable		 4l8wI-5i4qC:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 5i4q ELONGATION FACTOR TU
(Escherichia
coli) 		5 / 12 PHE C 323
LEU C 312
GLY C 340
THR C 383
MET C 359
 None
 1.22A 4mubA-5i4qC:
undetectable		 4mubA-5i4qC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5i4q ELONGATION FACTOR TU
(Escherichia
coli) 		4 / 6 ARG C 270
GLY C 269
GLU C 268
ARG C 231
 None
 0.96A 5btgA-5i4qC:
undetectable
5btgB-5i4qC:
undetectable
5btgC-5i4qC:
undetectable		 5btgA-5i4qC:
17.69
5btgB-5i4qC:
22.14
5btgC-5i4qC:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA612_1
(PHIAB6 TAILSPIKE)		 5i4q ELONGATION FACTOR TU
(Escherichia
coli) 		4 / 4 VAL C 228
THR C 226
GLU C 285
GLU C 286
 None
 1.39A 5jsdA-5i4qC:
0.0
5jsdB-5i4qC:
0.0		 5jsdA-5i4qC:
14.11
5jsdB-5i4qC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5i4q ELONGATION FACTOR TU
(Escherichia
coli) 		4 / 4 GLU C 285
GLU C 286
VAL C 228
THR C 226
 None
 1.39A 5jsdA-5i4qC:
0.0
5jsdC-5i4qC:
0.0		 5jsdA-5i4qC:
14.11
5jsdC-5i4qC:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 5i4q ELONGATION FACTOR TU
(Escherichia
coli) 		4 / 7 GLY C 317
ASP C 315
GLY C 354
ILE C 311
 None
 0.68A 5kqyB-5i4qC:
undetectable		 5kqyB-5i4qC:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5i4q CONTACT-DEPENDENT
INHIBITOR A
ELONGATION FACTOR TU
(Escherichia
coli;
Escherichia
coli) 		4 / 4 GLY C 258
LEU C 278
VAL A 205
GLU A 209
 None
 1.42A 5yw0A-5i4qC:
undetectable		 5yw0A-5i4qC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5i4q CONTACT-DEPENDENT
INHIBITOR A
(Escherichia
coli) 		3 / 3 TYR A 191
HIS A 248
MET A 237
 None
 1.01A 6af6A-5i4qA:
undetectable		 6af6A-5i4qA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 5i4q CONTACT-DEPENDENT
INHIBITOR A
CONTACT-DEPENDENT
INHIBITOR I
(Escherichia
coli) 		3 / 3 ARG B  85
LYS A 194
ARG A 222
 None
 1.27A 6az3C-5i4qB:
undetectable
6az3L-5i4qB:
undetectable
6az3M-5i4qB:
undetectable		 6az3C-5i4qB:
20.00
6az3L-5i4qB:
16.94
6az3M-5i4qB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 5i4q ELONGATION FACTOR TU
(Escherichia
coli) 		5 / 12 VAL C 392
VAL C 389
GLY C 290
THR C 339
GLY C 340
 None
 0.95A 6brdC-5i4qC:
undetectable		 6brdC-5i4qC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5i4q ELONGATION FACTOR TU
(Escherichia
coli) 		5 / 12 VAL C 338
ILE C 311
TYR C 327
THR C 341
PHE C 305
 None
None
SO4  C 401 (-4.9A)
None
None
 1.25A 6j20A-5i4qC:
undetectable		 6j20A-5i4qC:
17.42