SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		5 / 12 HIS A 424
HIS A 318
HIS A 485
HIS A 126
ASP A 236
 None
 1.25A 1a4lA-5i5jA:
undetectable		 1a4lA-5i5jA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 8 SER A  75
HIS A 125
SER A  71
ARG A  79
 None
 1.25A 1eqbA-5i5jA:
undetectable
1eqbB-5i5jA:
undetectable		 1eqbA-5i5jA:
20.60
1eqbB-5i5jA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 8 SER A  75
HIS A 125
SER A  71
ARG A  79
 None
 1.24A 1eqbA-5i5jA:
undetectable
1eqbB-5i5jA:
undetectable		 1eqbA-5i5jA:
20.60
1eqbB-5i5jA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 8 SER A  75
HIS A 125
SER A  71
ARG A  79
 None
 1.24A 1eqbC-5i5jA:
undetectable
1eqbD-5i5jA:
undetectable		 1eqbC-5i5jA:
20.60
1eqbD-5i5jA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 8 SER A  75
HIS A 125
SER A  71
ARG A  79
 None
 1.24A 1eqbC-5i5jA:
undetectable
1eqbD-5i5jA:
undetectable		 1eqbC-5i5jA:
20.60
1eqbD-5i5jA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 6 ASN A 461
ASP A 462
GLY A 478
THR A 480
 None
 0.81A 1n4fA-5i5jA:
undetectable		 1n4fA-5i5jA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 7 VAL A 231
VAL A 298
CYH A 251
CYH A 189
 None
 1.25A 1t46A-5i5jA:
2.5		 1t46A-5i5jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 7 VAL A 441
VAL A 475
CYH A 487
ARG A  79
 None
 1.28A 1t46A-5i5jA:
2.5		 1t46A-5i5jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		5 / 12 HIS A 426
GLY A  68
LEU A  81
PRO A 127
ILE A 143
 None
 1.02A 1zq9A-5i5jA:
undetectable		 1zq9A-5i5jA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		5 / 12 HIS A 426
ILE A 489
GLY A  68
PRO A 127
ILE A 143
 None
 0.97A 1zq9A-5i5jA:
undetectable		 1zq9A-5i5jA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 7 ALA A 393
THR A 384
ALA A 382
PRO A 371
 None
 0.97A 2ql8A-5i5jA:
undetectable
2ql8B-5i5jA:
undetectable		 2ql8A-5i5jA:
13.81
2ql8B-5i5jA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 8 SER A  75
HIS A 125
SER A  71
ARG A  79
 None
 1.18A 2vmyA-5i5jA:
undetectable
2vmyB-5i5jA:
undetectable		 2vmyA-5i5jA:
21.10
2vmyB-5i5jA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		5 / 12 PHE A 215
PHE A 351
VAL A 273
ALA A 240
PHE A 248
 None
 1.47A 3nuvA-5i5jA:
undetectable		 3nuvA-5i5jA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 6 HIS A 424
HIS A 126
HIS A 485
ASP A 236
 None
 1.16A 3nvcA-5i5jA:
undetectable		 3nvcA-5i5jA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 6 HIS A 485
HIS A 424
HIS A 126
ASP A 236
 None
 0.81A 3nvcA-5i5jA:
undetectable		 3nvcA-5i5jA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SDR_A_210A822_1
(ALPHA-BISABOLENE
SYNTHASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 4 ASP A 243
ASP A 241
ARG A 433
ASP A 133
 None
 1.38A 3sdrA-5i5jA:
undetectable		 3sdrA-5i5jA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SDV_A_911A822_0
(ALPHA-BISABOLENE
SYNTHASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 4 ASP A 243
ASP A 241
ARG A 433
ASP A 133
 None
 1.39A 3sdvA-5i5jA:
undetectable		 3sdvA-5i5jA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 6 ILE A 188
PHE A 274
HIS A 318
VAL A 313
 None
 1.23A 4a97I-5i5jA:
undetectable		 4a97I-5i5jA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 4 GLU A  77
ASP A  98
ARG A 150
THR A 101
 None
 1.49A 4ej1A-5i5jA:
undetectable		 4ej1A-5i5jA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		3 / 3 GLU A 431
ARG A 177
HIS A 128
 None
 0.86A 4kf9A-5i5jA:
undetectable		 4kf9A-5i5jA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		5 / 12 PHE A 481
GLY A  73
ALA A 152
ARG A  91
ILE A 154
 None
 1.16A 4krhB-5i5jA:
undetectable		 4krhB-5i5jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		3 / 3 TYR A 246
ARG A 278
SER A 275
 None
 1.22A 4lf7I-5i5jA:
undetectable
4lf7J-5i5jA:
undetectable		 4lf7I-5i5jA:
13.20
4lf7J-5i5jA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		3 / 3 TYR A 246
ARG A 278
SER A 275
 None
 1.22A 4lf8I-5i5jA:
undetectable
4lf8J-5i5jA:
undetectable		 4lf8I-5i5jA:
13.20
4lf8J-5i5jA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		3 / 3 LYS A 527
ASN A 549
ASP A 525
 None
 0.88A 4o1eA-5i5jA:
undetectable		 4o1eA-5i5jA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 6 LEU A 214
LEU A 299
VAL A 298
PHE A 215
 None
 1.19A 4uswA-5i5jA:
undetectable		 4uswA-5i5jA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		3 / 3 ASP A 348
SER A 275
TYR A 246
 None
 0.87A 5glmA-5i5jA:
5.9		 5glmA-5i5jA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		3 / 3 HIS A  74
ASP A 123
HIS A 125
 None
 0.67A 5oexA-5i5jA:
27.8		 5oexA-5i5jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		3 / 3 HIS A 426
HIS A 424
HIS A 485
 None
 0.77A 5oexA-5i5jA:
27.8		 5oexA-5i5jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		3 / 3 HIS A  74
ASP A 123
HIS A 125
 None
 0.59A 5oexB-5i5jA:
8.9		 5oexB-5i5jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		3 / 3 HIS A  74
ASP A 123
HIS A 125
 None
 0.59A 5oexC-5i5jA:
7.4		 5oexC-5i5jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		3 / 3 HIS A  74
ASP A 123
HIS A 125
 None
 0.60A 5oexD-5i5jA:
27.7		 5oexD-5i5jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		3 / 3 MET A 514
GLU A 558
ARG A 536
 None
 1.11A 5tjyA-5i5jA:
undetectable		 5tjyA-5i5jA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		3 / 3 MET A 514
GLU A 558
ARG A 536
 None
 1.05A 5tjzA-5i5jA:
undetectable		 5tjzA-5i5jA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 5i5j NITROUS-OXIDE
REDUCTASE
(Shewanella
denitrificans) 		4 / 7 ASP A 434
SER A 135
GLY A 134
VAL A 181
 None
 0.78A 6ekzA-5i5jA:
undetectable		 6ekzA-5i5jA:
9.59