SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		5 / 10 VAL A  26
LEU A  28
SER A  49
VAL A  52
MET A 243
 None
 1.38A 1fdwA-5i5pA:
undetectable		 1fdwA-5i5pA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		5 / 12 ALA A 141
LEU A 267
ALA A 268
VAL A  62
ILE A  64
 None
PEG  A 402 ( 4.8A)
None
None
None
 0.83A 1fm6U-5i5pA:
undetectable		 1fm6U-5i5pA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		5 / 11 PHE A 143
ILE A 259
ALA A 263
LEU A 267
ALA A 268
 None
None
None
PEG  A 402 ( 4.8A)
None
 1.01A 1jb0B-5i5pA:
undetectable		 1jb0B-5i5pA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		5 / 9 TYR A 137
VAL A  89
VAL A  85
ASP A  83
VAL A  86
 None
 1.00A 2l8mA-5i5pA:
undetectable		 2l8mA-5i5pA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		4 / 6 LEU A 296
MET A 168
MET A 206
LEU A 179
 None
 1.47A 2oz7A-5i5pA:
undetectable		 2oz7A-5i5pA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		5 / 11 HIS A 145
ILE A 175
LEU A 234
ILE A 150
ILE A 203
 PHB  A 401 ( 4.2A)
None
None
None
None
 1.05A 3b2rB-5i5pA:
undetectable		 3b2rB-5i5pA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		4 / 8 ALA A 160
LEU A 182
MET A 304
ILE A 293
 None
 0.80A 3cldB-5i5pA:
undetectable		 3cldB-5i5pA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		5 / 9 SER A 231
ILE A 337
ALA A 117
ALA A 146
THR A 236
 None
 1.14A 3mdtA-5i5pA:
undetectable		 3mdtA-5i5pA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		5 / 11 PHE A 143
ILE A 259
ALA A 263
LEU A 267
ALA A 268
 None
None
None
PEG  A 402 ( 4.8A)
None
 1.00A 3pcqB-5i5pA:
undetectable		 3pcqB-5i5pA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		5 / 12 VAL A 142
LEU A 134
GLY A  94
ALA A  93
LEU A 103
 None
 1.04A 3rr3A-5i5pA:
undetectable		 3rr3A-5i5pA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		5 / 12 VAL A 142
LEU A 134
GLY A  94
ALA A  93
LEU A 103
 None
 1.04A 3rr3B-5i5pA:
undetectable		 3rr3B-5i5pA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		3 / 3 GLY A 299
PRO A 300
ALA A 160
 None
 0.51A 4qn9B-5i5pA:
undetectable		 4qn9B-5i5pA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		4 / 6 LEU A 140
TRP A  48
SER A  49
PRO A  47
 None
None
None
PEG  A 402 (-3.4A)
 1.19A 5b8iA-5i5pA:
undetectable		 5b8iA-5i5pA:
25.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		5 / 12 PHE A  33
TRP A  90
HIS A 145
PRO A 171
PHE A 239
 PHB  A 401 ( 4.5A)
None
PHB  A 401 ( 4.2A)
PHB  A 401 (-4.2A)
PHB  A 401 ( 4.1A)
 0.61A 5im2A-5i5pA:
49.0		 5im2A-5i5pA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IM2_A_BEZA401_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		4 / 4 TYR A  95
ARG A 169
PRO A 209
GLU A 211
 PHB  A 401 (-4.5A)
PHB  A 401 (-3.0A)
PHB  A 401 ( 4.0A)
PHB  A 401 (-3.1A)
 0.28A 5im2A-5i5pA:
49.0		 5im2A-5i5pA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		4 / 6 MET A 178
ALA A 160
LEU A 163
ALA A 184
 None
 1.05A 6fosB-5i5pA:
1.5		 6fosB-5i5pA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN
(uncultured
marine
bacterium) 		4 / 5 TYR A 235
VAL A 280
MET A 206
GLY A 170
 None
 1.34A 6hd4A-5i5pA:
undetectable		 6hd4A-5i5pA:
12.88