SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i61'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 12 PRO B  37
LEU B 426
TYR B  39
LEU B 464
LEU B 530
 None
 1.20A 1e7wA-5i61B:
undetectable		 1e7wA-5i61B:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 12 TYR B 218
ASP B 330
GLY B 325
PHE B 206
TYR B 302
 None
 1.04A 1maaA-5i61B:
undetectable		 1maaA-5i61B:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		4 / 6 TRP B   8
GLY B 143
PHE B 147
SER B 142
 None
 1.35A 2a3cA-5i61B:
undetectable		 2a3cA-5i61B:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		4 / 6 TRP B   8
GLY B 143
PHE B 147
SER B 142
 None
 1.34A 2a3cB-5i61B:
undetectable		 2a3cB-5i61B:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		4 / 6 ARG B 408
ASP B 406
THR B 405
ASP B 249
 None
 0.96A 2j2pE-5i61B:
undetectable
2j2pF-5i61B:
undetectable		 2j2pE-5i61B:
17.13
2j2pF-5i61B:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		4 / 6 TRP B   8
GLY B 143
GLY B 180
PHE B  23
 None
 0.87A 2qx6A-5i61B:
undetectable
2qx6B-5i61B:
undetectable		 2qx6A-5i61B:
16.89
2qx6B-5i61B:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		3 / 3 MET B 428
VAL B  81
GLU B 190
 None
 0.74A 3c6gA-5i61B:
undetectable		 3c6gA-5i61B:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		3 / 3 PHE B 463
CYH B 467
PHE B  38
 None
 1.13A 3cr5X-5i61B:
undetectable		 3cr5X-5i61B:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 12 PRO B  84
GLY B  29
VAL B 202
ASP B  91
LEU B 306
 None
 1.01A 3m6vA-5i61B:
undetectable		 3m6vA-5i61B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 12 PRO B  84
GLY B  29
VAL B 202
ASP B  91
LEU B 306
 None
 0.98A 3m6vB-5i61B:
undetectable		 3m6vB-5i61B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 12 PRO B  84
GLY B  29
VAL B 202
ASP B  91
LEU B 306
 None
 1.01A 3m6wA-5i61B:
undetectable		 3m6wA-5i61B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q07_B_WPPB400_2
(BETA-LACTAMASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		4 / 5 CYH B 356
TYR B 365
PRO B 352
THR B 260
 None
 1.26A 3q07B-5i61B:
undetectable		 3q07B-5i61B:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 9 ASP B 266
SER B 324
GLY B 358
ASP B 359
ASP B 360
 None
 1.09A 3sfuA-5i61B:
20.9		 3sfuA-5i61B:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 9 ASP B 266
THR B 327
GLY B 358
ASP B 359
ASP B 360
 None
 0.82A 3sfuA-5i61B:
20.9		 3sfuA-5i61B:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 9 ASP B 266
GLY B 358
ASP B 359
ASP B 360
LEU B 399
 None
 0.25A 3sfuB-5i61B:
22.3		 3sfuB-5i61B:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 9 THR B 332
GLY B 358
ASP B 359
ASP B 360
LEU B 399
 None
 1.31A 3sfuB-5i61B:
22.3		 3sfuB-5i61B:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 12 LEU B 285
ASP B 330
SER B 324
PHE B 206
ASN B 211
 None
 1.36A 4amjB-5i61B:
undetectable		 4amjB-5i61B:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		3 / 3 TRP B  62
TRP B 402
THR B  64
 None
 1.09A 4bboB-5i61B:
undetectable		 4bboB-5i61B:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		4 / 8 VAL B 231
TRP B 234
LEU B 284
LEU B 221
 None
 0.98A 4jtrA-5i61B:
undetectable		 4jtrA-5i61B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		3 / 3 GLU B 341
ARG B 379
HIS B 380
 None
 0.61A 4kf9A-5i61B:
undetectable		 4kf9A-5i61B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 12 SER B 354
THR B 348
THR B 349
ALA B 343
GLY B 252
 None
 1.25A 4qvnV-5i61B:
undetectable
4qvnb-5i61B:
undetectable		 4qvnV-5i61B:
17.29
4qvnb-5i61B:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 12 SER B 354
THR B 348
THR B 349
ALA B 343
GLY B 252
 None
 1.24A 4qvnH-5i61B:
undetectable
4qvnN-5i61B:
undetectable		 4qvnH-5i61B:
17.29
4qvnN-5i61B:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 11 LEU B 221
LEU B 333
GLU B 279
ALA B 282
LEU B 281
 None
 0.93A 4wg0B-5i61B:
undetectable
4wg0C-5i61B:
undetectable
4wg0D-5i61B:
undetectable		 4wg0B-5i61B:
3.35
4wg0C-5i61B:
3.35
4wg0D-5i61B:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 11 LEU B 221
LEU B 333
GLU B 279
ALA B 282
LEU B 281
 None
 0.92A 4wg0D-5i61B:
undetectable
4wg0E-5i61B:
undetectable
4wg0F-5i61B:
undetectable		 4wg0D-5i61B:
3.35
4wg0E-5i61B:
3.35
4wg0F-5i61B:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		3 / 3 TRP B  51
ILE B  58
SER B  57
 None
 1.02A 5gqbA-5i61B:
undetectable		 5gqbA-5i61B:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 12 ALA B 182
ALA B 307
PHE B  23
TYR B  22
LEU B  19
 None
 1.06A 5k9dA-5i61B:
undetectable		 5k9dA-5i61B:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		4 / 5 ASP B 436
GLY B 439
PRO B 435
TRP B 438
 None
 1.15A 5nn8A-5i61B:
undetectable		 5nn8A-5i61B:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 12 VAL B 334
LEU B 280
GLY B 120
PHE B 225
VAL B 231
 None
 1.11A 6drzA-5i61B:
undetectable		 6drzA-5i61B:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		4 / 5 PHE B 208
VAL B 297
MET B 136
VAL B 154
 None
 1.40A 6ekzA-5i61B:
undetectable		 6ekzA-5i61B:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		4 / 8 ASN B 270
PHE B 106
HIS B 380
TYR B 377
 None
 1.20A 6huoC-5i61B:
undetectable
6huoD-5i61B:
undetectable		 6huoC-5i61B:
10.36
6huoD-5i61B:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		5 / 12 SER B 354
THR B 348
THR B 349
ALA B 343
GLY B 252
 None
 1.25A 6hwdH-5i61B:
undetectable
6hwdN-5i61B:
undetectable		 6hwdH-5i61B:
9.43
6hwdN-5i61B:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE
(Human
picobirnavirus) 		4 / 7 ASP B 330
TYR B 218
GLU B 214
CYH B 169
 None
 1.12A 6mn5E-5i61B:
undetectable		 6mn5E-5i61B:
10.08