SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i67'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 408
LEU A 293
LYS A 254
TYR A 264
 PEG  A 702 ( 4.8A)
None
None
None
 0.94A 1gtiD-5i67A:
undetectable		 1gtiD-5i67A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 408
LEU A 293
LYS A 254
TYR A 264
 PEG  A 702 ( 4.8A)
None
None
None
 0.94A 1gtiE-5i67A:
undetectable		 1gtiE-5i67A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		5 / 11 PHE A 416
ALA A 268
ALA A 266
VAL A 409
LEU A 293
 None
 1.25A 1hbpA-5i67A:
undetectable		 1hbpA-5i67A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 4 HIS A 435
ALA A 430
PHE A 496
GLY A 540
 None
 1.40A 1mjoA-5i67A:
undetectable		 1mjoA-5i67A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 233
LEU A 226
MET A 159
MET A 156
MET A 132
 None
 1.44A 1sqnA-5i67A:
undetectable		 1sqnA-5i67A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.41A 1v54A-5i67A:
undetectable
1v54C-5i67A:
undetectable		 1v54A-5i67A:
20.09
1v54C-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.43A 1v54N-5i67A:
undetectable
1v54P-5i67A:
undetectable		 1v54N-5i67A:
20.09
1v54P-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.41A 1v55A-5i67A:
undetectable
1v55C-5i67A:
undetectable		 1v55A-5i67A:
20.09
1v55C-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.41A 2dyrA-5i67A:
undetectable
2dyrC-5i67A:
undetectable		 2dyrA-5i67A:
20.09
2dyrC-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.44A 2dyrN-5i67A:
undetectable
2dyrP-5i67A:
undetectable		 2dyrN-5i67A:
20.09
2dyrP-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.43A 2eijA-5i67A:
undetectable
2eijC-5i67A:
undetectable		 2eijA-5i67A:
20.09
2eijC-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.44A 2eijN-5i67A:
undetectable
2eijP-5i67A:
undetectable		 2eijN-5i67A:
20.09
2eijP-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.40A 2eikA-5i67A:
undetectable
2eikC-5i67A:
undetectable		 2eikA-5i67A:
20.09
2eikC-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.44A 2eikN-5i67A:
undetectable
2eikP-5i67A:
undetectable		 2eikN-5i67A:
20.09
2eikP-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.41A 2eilA-5i67A:
undetectable
2eilC-5i67A:
undetectable		 2eilA-5i67A:
20.09
2eilC-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.44A 2eilN-5i67A:
undetectable
2eilP-5i67A:
undetectable		 2eilN-5i67A:
20.09
2eilP-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 5 TRP A 354
ALA A 346
LEU A 358
ALA A 382
 None
 1.30A 2jstA-5i67A:
undetectable
2jstB-5i67A:
undetectable		 2jstA-5i67A:
9.19
2jstB-5i67A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 527
VAL A 566
THR A 537
 None
 0.77A 2nmzA-5i67A:
undetectable		 2nmzA-5i67A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  19
LEU A 226
MET A 170
MET A 132
 None
 1.12A 2oaxF-5i67A:
undetectable		 2oaxF-5i67A:
17.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		6 / 8 ARG A  81
LYS A 228
LYS A 229
HIS A 249
ASP A 296
ARG A 388
 None
None
MN  A 705 (-3.1A)
MN  A 705 (-4.5A)
MN  A 705 (-3.5A)
None
 0.71A 2rk8A-5i67A:
41.6		 2rk8A-5i67A:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		6 / 8 LYS A 228
LYS A 229
HIS A 249
SER A 271
ASP A 296
ARG A 388
 None
MN  A 705 (-3.1A)
MN  A 705 (-4.5A)
MN  A 705 (-4.7A)
MN  A 705 (-3.5A)
None
 1.02A 2rk8A-5i67A:
41.6		 2rk8A-5i67A:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		6 / 7 ARG A  81
LYS A 228
LYS A 229
HIS A 249
ASP A 296
ARG A 388
 None
None
MN  A 705 (-3.1A)
MN  A 705 (-4.5A)
MN  A 705 (-3.5A)
None
 0.56A 2rk8B-5i67A:
51.3		 2rk8B-5i67A:
51.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		6 / 7 ARG A  81
LYS A 228
LYS A 229
SER A 271
ASP A 296
ARG A 388
 None
None
MN  A 705 (-3.1A)
MN  A 705 (-4.7A)
MN  A 705 (-3.5A)
None
 0.92A 2rk8B-5i67A:
51.3		 2rk8B-5i67A:
51.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 578
LEU A 577
VAL A 458
GLY A 444
THR A 442
 None
 1.10A 2wd9C-5i67A:
undetectable		 2wd9C-5i67A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.41A 2y69A-5i67A:
undetectable
2y69C-5i67A:
undetectable		 2y69A-5i67A:
20.09
2y69C-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.43A 3abkA-5i67A:
undetectable
3abkC-5i67A:
undetectable		 3abkA-5i67A:
20.09
3abkC-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.42A 3abkN-5i67A:
undetectable
3abkP-5i67A:
undetectable		 3abkN-5i67A:
20.09
3abkP-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.40A 3abmN-5i67A:
undetectable
3abmP-5i67A:
undetectable		 3abmN-5i67A:
20.09
3abmP-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.40A 3ag2A-5i67A:
undetectable
3ag2C-5i67A:
undetectable		 3ag2A-5i67A:
20.09
3ag2C-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.44A 3ag2N-5i67A:
undetectable
3ag2P-5i67A:
undetectable		 3ag2N-5i67A:
20.09
3ag2P-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.42A 3ag3A-5i67A:
undetectable
3ag3C-5i67A:
undetectable		 3ag3A-5i67A:
20.09
3ag3C-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.42A 3ag3N-5i67A:
undetectable
3ag3P-5i67A:
undetectable		 3ag3N-5i67A:
20.09
3ag3P-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.43A 3ag4A-5i67A:
undetectable
3ag4C-5i67A:
undetectable		 3ag4A-5i67A:
20.09
3ag4C-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.45A 3ag4N-5i67A:
undetectable
3ag4P-5i67A:
undetectable		 3ag4N-5i67A:
20.09
3ag4P-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 4 THR A 442
VAL A 424
GLY A 540
THR A 541
 None
 0.60A 3cflA-5i67A:
undetectable		 3cflA-5i67A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		3 / 3 PHE A  45
CYH A  49
PHE A  58
 PEG  A 703 ( 3.6A)
None
None
 0.85A 3cr5X-5i67A:
undetectable		 3cr5X-5i67A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 527
VAL A 566
THR A 537
 None
 0.68A 3ndtA-5i67A:
undetectable		 3ndtA-5i67A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1480_0
(MJ0495-LIKE PROTEIN)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 261
GLU A 291
ILE A 256
SER A 257
 None
 1.27A 4ac9C-5i67A:
2.4		 4ac9C-5i67A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 261
GLU A 291
ILE A 256
SER A 257
 None
 1.24A 4acaC-5i67A:
undetectable		 4acaC-5i67A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1480_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 4 LYS A 261
GLU A 291
ILE A 256
SER A 257
 None
 1.26A 4acbC-5i67A:
2.3		 4acbC-5i67A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		3 / 3 TYR A  87
ARG A  85
SER A  84
 None
 1.05A 4dr2I-5i67A:
undetectable
4dr2J-5i67A:
undetectable		 4dr2I-5i67A:
11.59
4dr2J-5i67A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		3 / 3 TYR A  87
ARG A  85
SER A  84
 None
 1.21A 4lf7I-5i67A:
undetectable
4lf7J-5i67A:
undetectable		 4lf7I-5i67A:
11.59
4lf7J-5i67A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		3 / 3 TYR A  87
ARG A  85
SER A  84
 None
 1.21A 4lf8I-5i67A:
undetectable
4lf8J-5i67A:
undetectable		 4lf8I-5i67A:
11.59
4lf8J-5i67A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		3 / 3 SER A 199
ASP A 148
ASP A  33
 None
 0.82A 4mwzA-5i67A:
undetectable		 4mwzA-5i67A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 337
LYS A  67
THR A 391
THR A 340
 None
 1.40A 4w5qA-5i67A:
undetectable		 4w5qA-5i67A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 443
ALA A 268
MET A 250
MET A 465
 None
 0.80A 4wboC-5i67A:
undetectable		 4wboC-5i67A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  73
ASN A 371
THR A 378
ALA A 382
VAL A 345
 None
 1.22A 4x1iB-5i67A:
undetectable		 4x1iB-5i67A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.44A 5b1aN-5i67A:
undetectable
5b1aP-5i67A:
undetectable		 5b1aN-5i67A:
20.09
5b1aP-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.41A 5b1bN-5i67A:
undetectable
5b1bP-5i67A:
undetectable		 5b1bN-5i67A:
20.09
5b1bP-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.45A 5b3sN-5i67A:
undetectable
5b3sP-5i67A:
undetectable		 5b3sN-5i67A:
20.09
5b3sP-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 417
SER A 273
GLY A 274
ALA A 268
 None
None
GDP  A 701 (-3.2A)
None
 0.86A 5e26A-5i67A:
undetectable
5e26B-5i67A:
undetectable		 5e26A-5i67A:
22.24
5e26B-5i67A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 417
SER A 273
GLY A 274
ALA A 268
 None
None
GDP  A 701 (-3.2A)
None
 0.87A 5e26C-5i67A:
undetectable
5e26D-5i67A:
undetectable		 5e26C-5i67A:
22.24
5e26D-5i67A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 268
GLY A 417
SER A 273
GLY A 274
 None
None
None
GDP  A 701 (-3.2A)
 0.90A 5e26C-5i67A:
undetectable
5e26D-5i67A:
undetectable		 5e26C-5i67A:
22.24
5e26D-5i67A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 288
GLU A 259
ASP A 526
 None
 0.89A 5gqbA-5i67A:
undetectable		 5gqbA-5i67A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 176
GLU A 212
GLU A  25
VAL A  26
 None
 1.23A 5h4dA-5i67A:
undetectable		 5h4dA-5i67A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 8 ASN A 100
GLU A 248
HIS A 249
THR A 205
 None
None
MN  A 705 (-4.5A)
None
 1.35A 5hqaA-5i67A:
undetectable		 5hqaA-5i67A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.46A 5iy5A-5i67A:
undetectable
5iy5C-5i67A:
undetectable		 5iy5A-5i67A:
20.09
5iy5C-5i67A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 529
HIS A 530
ARG A 527
 None
 0.97A 5uunA-5i67A:
undetectable		 5uunA-5i67A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.46A 5x1fN-5i67A:
undetectable
5x1fP-5i67A:
undetectable		 5x1fN-5i67A:
20.09
5x1fP-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 296
PHE A 468
ARG A  81
 MN  A 705 (-3.5A)
None
None
 1.11A 5yw0A-5i67A:
undetectable		 5yw0A-5i67A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.41A 5zcqN-5i67A:
undetectable
5zcqP-5i67A:
undetectable		 5zcqN-5i67A:
20.09
5zcqP-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 345
ALA A 320
TRP A 355
LEU A  61
THR A 391
 None
 1.16A 6dk1C-5i67A:
undetectable		 6dk1C-5i67A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBP_B_ADNB404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 296
ILE A 297
PRO A 467
LYS A 229
SER A 232
 MN  A 705 (-3.5A)
None
None
MN  A 705 (-3.1A)
None
 1.23A 6fbpA-5i67A:
undetectable
6fbpB-5i67A:
undetectable		 6fbpA-5i67A:
9.08
6fbpB-5i67A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.49A 6nmfN-5i67A:
undetectable
6nmfP-5i67A:
undetectable		 6nmfN-5i67A:
20.09
6nmfP-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 433
ASP A 305
TRP A 480
HIS A 479
 None
 1.47A 6nmpN-5i67A:
undetectable
6nmpP-5i67A:
undetectable		 6nmpN-5i67A:
20.09
6nmpP-5i67A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]
(Mycobacterium
tuberculosis) 		5 / 10 ILE A  59
LEU A 365
ASP A 352
LEU A  61
GLY A 351
 None
 1.43A 6r2eD-5i67A:
undetectable		 6r2eD-5i67A:
20.13