SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 8 ILE A 131
VAL A 367
ASN A 410
ASN A 409
GLY A 424
 None
 1.27A 1dzmA-5i6cA:
undetectable		 1dzmA-5i6cA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_B_BZMB600_0
(ODORANT-BINDING
PROTEIN)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 9 ILE A 131
VAL A 367
ASN A 410
ASN A 409
GLY A 424
 None
 1.25A 1dzmB-5i6cA:
undetectable		 1dzmB-5i6cA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 9 GLY A 359
ALA A 384
THR A 405
THR A 364
SER A 149
 LMT  A1002 ( 3.9A)
None
None
None
None
 1.38A 1gtnR-5i6cA:
undetectable
1gtnS-5i6cA:
undetectable		 1gtnR-5i6cA:
8.03
1gtnS-5i6cA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 11 LEU A  91
ALA A 461
VAL A  95
MET A 455
LEU A 302
 None
 1.33A 1kt6A-5i6cA:
undetectable		 1kt6A-5i6cA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 11 LEU A  91
ALA A 461
VAL A  95
MET A 455
LEU A 302
 None
 1.27A 1kt7A-5i6cA:
undetectable		 1kt7A-5i6cA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 12 MET A 400
GLY A 152
VAL A 150
MET A  90
LEU A 120
 None
 1.35A 1nhzA-5i6cA:
undetectable		 1nhzA-5i6cA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 11 LEU A 496
GLY A 527
GLY A 491
TYR A 492
ILE A 232
 None
 1.02A 1p91A-5i6cA:
undetectable		 1p91A-5i6cA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		4 / 4 LEU A 431
LEU A 125
MET A  90
MET A 403
 None
 1.35A 2oaxB-5i6cA:
0.6		 2oaxB-5i6cA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		4 / 7 PHE A 165
ALA A 188
THR A 399
LEU A 115
 None
 0.92A 2wx2A-5i6cA:
undetectable		 2wx2A-5i6cA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		4 / 7 GLY A  69
ILE A 413
THR A 364
LEU A  70
 None
 0.81A 2xrhA-5i6cA:
0.7		 2xrhA-5i6cA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 12 SER A 297
PHE A 276
GLY A 454
ILE A 272
THR A 457
 LMT  A1003 ( 4.9A)
None
None
None
None
 1.28A 3a25A-5i6cA:
undetectable		 3a25A-5i6cA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 9 PRO A 448
VAL A 451
GLY A 454
ILE A 282
GLY A 305
 None
 0.96A 3csjB-5i6cA:
undetectable		 3csjB-5i6cA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		4 / 8 ILE A 157
ALA A 161
PHE A 165
ALA A 188
 None
 0.92A 3hrdA-5i6cA:
undetectable
3hrdB-5i6cA:
undetectable		 3hrdA-5i6cA:
23.55
3hrdB-5i6cA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		4 / 7 PRO A 448
ILE A 447
GLY A 305
VAL A 278
 None
 0.80A 4a3uB-5i6cA:
undetectable		 4a3uB-5i6cA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 12 SER A 154
VAL A 153
GLN A 112
ILE A 101
SER A 103
 XAN  A1001 (-3.5A)
None
None
None
None
 1.38A 4c49C-5i6cA:
undetectable		 4c49C-5i6cA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 12 GLY A 340
PRO A 341
PHE A 165
THR A 195
GLY A 190
 None
 1.29A 4n48A-5i6cA:
undetectable		 4n48A-5i6cA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 12 ALA A  89
THR A 404
SER A 127
PHE A 406
ASN A 409
 None
XAN  A1001 (-4.7A)
None
XAN  A1001 (-3.5A)
None
 1.44A 5hgcA-5i6cA:
undetectable		 5hgcA-5i6cA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		4 / 8 ILE A 292
CYH A 296
LEU A  88
VAL A 451
 None
 0.70A 5owrA-5i6cA:
undetectable		 5owrA-5i6cA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		4 / 5 GLY A 238
ASP A 241
MET A 452
GLN A 112
 None
 1.27A 5ubbA-5i6cA:
undetectable		 5ubbA-5i6cA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 9 GLY A 124
LEU A 431
LEU A  82
GLY A 152
ILE A 413
 None
 0.58A 5vkqC-5i6cA:
2.5
5vkqD-5i6cA:
2.5		 5vkqC-5i6cA:
15.78
5vkqD-5i6cA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 5i6c URIC ACID-XANTHINE
PERMEASE
(Aspergillus
nidulans) 		5 / 11 ILE A 432
LEU A 429
MET A 151
LEU A 126
MET A 128
 None
 1.49A 6hupA-5i6cA:
undetectable
6hupB-5i6cA:
undetectable		 6hupA-5i6cA:
8.46
6hupB-5i6cA:
10.26