SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1347
GLN A1354
ILE A1427
LEU A1357
TYR A1080
 None
 1.18A 1dhfA-5i6eA:
undetectable		 1dhfA-5i6eA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1347
GLN A1354
ILE A1427
LEU A1357
TYR A1080
 None
 1.09A 1dhfB-5i6eA:
undetectable		 1dhfB-5i6eA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1347
GLN A1354
ILE A1427
LEU A1357
TYR A1080
 None
 1.17A 1dlsA-5i6eA:
undetectable		 1dlsA-5i6eA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A1385
PHE A1407
PHE A1404
PHE A1389
 None
 1.19A 1e71M-5i6eA:
undetectable		 1e71M-5i6eA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A1385
PHE A1407
PHE A1404
PHE A1389
 None
 1.19A 1e72M-5i6eA:
undetectable		 1e72M-5i6eA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 THR A1229
LEU A1183
VAL A1186
LEU A1190
 None
 0.92A 1fbmB-5i6eA:
undetectable		 1fbmB-5i6eA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 884
LEU A 907
ILE A 847
VAL A 866
PHE A 876
 None
 1.01A 1gx8A-5i6eA:
0.9		 1gx8A-5i6eA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A1345
ILE A1351
ILE A1342
ILE A1353
ILE A1347
 None
 0.96A 1hshC-5i6eA:
undetectable		 1hshC-5i6eA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 THR A1229
LEU A1183
VAL A1186
LEU A1190
 None
 0.94A 1mz9D-5i6eA:
undetectable		 1mz9D-5i6eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 SEP  A1157 ( 2.8A)
None
None
 0.87A 1nodB-5i6eA:
undetectable		 1nodB-5i6eA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 836
HIS A 921
HIS A 923
PHE A 926
VAL A 927
 None
 1.13A 1qu2A-5i6eA:
undetectable		 1qu2A-5i6eA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1177
VAL A1129
TYR A1105
LEU A1069
LEU A1072
 None
 1.09A 1s19A-5i6eA:
undetectable		 1s19A-5i6eA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 ALA A1361
LEU A1364
ILE A1342
SER A1359
 None
 1.08A 1sbrA-5i6eA:
undetectable
1sbrB-5i6eA:
undetectable		 1sbrA-5i6eA:
14.14
1sbrB-5i6eA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 SEP  A1157 ( 2.8A)
None
None
 0.90A 2nodB-5i6eA:
undetectable		 2nodB-5i6eA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 ILE A1347
ARG A1363
ILE A1342
PHE A1393
 None
 1.09A 2q72A-5i6eA:
undetectable		 2q72A-5i6eA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 TRP A 843
ALA A 911
PRO A 877
ALA A 878
 None
 0.99A 2zgwA-5i6eA:
undetectable		 2zgwA-5i6eA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A1275
TYR A1272
ILE A1341
HIS A1321
 None
MLI  A1501 (-4.4A)
None
None
 1.06A 2zm7A-5i6eA:
undetectable		 2zm7A-5i6eA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1469
HIS A1384
VAL A1400
LEU A1440
TYR A1487
 None
 1.30A 3dzyD-5i6eA:
undetectable		 3dzyD-5i6eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 SEP  A1157 ( 2.8A)
None
None
 0.85A 3e7iB-5i6eA:
undetectable		 3e7iB-5i6eA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 ILE A1292
ARG A1441
ILE A1341
THR A1288
 None
 1.15A 3ia4C-5i6eA:
undetectable		 3ia4C-5i6eA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 ILE A1342
ARG A1410
ILE A1387
THR A1344
 None
 1.23A 3ia4C-5i6eA:
undetectable		 3ia4C-5i6eA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.06A 3ndwB-5i6eA:
undetectable		 3ndwB-5i6eA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1173
ILE A1115
TRP A1131
 SEP  A1157 ( 2.8A)
None
None
 0.89A 3nw2B-5i6eA:
undetectable		 3nw2B-5i6eA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A1086
ALA A1102
MET A1264
ASN A1223
 None
 1.45A 3uq6A-5i6eA:
undetectable		 3uq6A-5i6eA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 912
LEU A 850
LEU A 900
ASP A 859
 None
 1.05A 4aqlA-5i6eA:
undetectable		 4aqlA-5i6eA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1347
GLN A1354
ILE A1427
LEU A1357
TYR A1080
 None
 1.13A 4kebB-5i6eA:
undetectable		 4kebB-5i6eA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A1316
ASP A1367
SER A 996
ALA A 920
 None
 1.15A 4nedA-5i6eA:
undetectable		 4nedA-5i6eA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 884
ARG A 868
GLU A 863
ALA A 856
 None
 0.92A 4nkxA-5i6eA:
undetectable		 4nkxA-5i6eA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1086
LEU A1075
ILE A1076
LEU A1072
ILE A1115
 None
 0.96A 4odrA-5i6eA:
undetectable
4odrB-5i6eA:
undetectable		 4odrA-5i6eA:
9.62
4odrB-5i6eA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 935
THR A1005
HIS A1009
 None
 0.79A 4q15A-5i6eA:
undetectable		 4q15A-5i6eA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 935
THR A1005
HIS A1009
 None
 0.80A 4q15B-5i6eA:
undetectable		 4q15B-5i6eA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 935
THR A1005
HIS A1009
 None
 0.72A 4ydqB-5i6eA:
undetectable		 4ydqB-5i6eA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 876
HIS A 912
LEU A 907
PRO A 877
 None
 1.46A 5csyB-5i6eA:
undetectable		 5csyB-5i6eA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA A1361
ILE A1385
GLY A1340
ILE A1341
ILE A1425
 None
 1.16A 5kr0A-5i6eA:
undetectable		 5kr0A-5i6eA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1086
ALA A1101
PRO A1067
SER A1051
ILE A1076
 None
 1.20A 5ljbA-5i6eA:
undetectable		 5ljbA-5i6eA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 854
PRO A 906
ALA A 908
VAL A 889
PRO A 896
 None
 1.28A 5m0oA-5i6eA:
undetectable		 5m0oA-5i6eA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 MET A 862
LEU A 865
ARG A 868
ILE A 885
LEU A 881
 None
 1.13A 5toaB-5i6eA:
undetectable		 5toaB-5i6eA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 5i6e ACETYL-COA
CARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A1407
LEU A1408
SER A1422
THR A1338
 None
 0.95A 6f88A-5i6eA:
0.7		 6f88A-5i6eA:
8.05