SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 5i6r SLIT-ROBO RHO
GTPASE-ACTIVATING
PROTEIN 2
(Homo
sapiens) 		4 / 6 LEU A 458
GLY A 460
LYS A 388
TYR A 457
 None
 1.10A 1gtiC-5i6rA:
undetectable		 1gtiC-5i6rA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5i6r SLIT-ROBO RHO
GTPASE-ACTIVATING
PROTEIN 2
(Homo
sapiens) 		4 / 5 LEU A 458
GLY A 460
LYS A 388
TYR A 457
 None
 1.10A 1gtiF-5i6rA:
undetectable		 1gtiF-5i6rA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5i6r SLIT-ROBO RHO
GTPASE-ACTIVATING
PROTEIN 2
(Homo
sapiens) 		4 / 8 PHE A 128
GLY A 283
PHE A 295
PHE A  53
 None
 1.10A 3ko0B-5i6rA:
undetectable
3ko0J-5i6rA:
undetectable		 3ko0B-5i6rA:
11.97
3ko0J-5i6rA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 5i6r SLIT-ROBO RHO
GTPASE-ACTIVATING
PROTEIN 2
(Homo
sapiens) 		4 / 7 TYR A  17
ASN A 261
LEU A 254
LEU A 160
 None
 1.23A 3nk2X-5i6rA:
undetectable		 3nk2X-5i6rA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5i6r SLIT-ROBO RHO
GTPASE-ACTIVATING
PROTEIN 2
(Homo
sapiens) 		3 / 3 LYS A 143
ARG A  42
VAL A  43
 None
 0.93A 4x3uA-5i6rA:
undetectable
4x3uB-5i6rA:
undetectable		 4x3uA-5i6rA:
8.06
4x3uB-5i6rA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5i6r SLIT-ROBO RHO
GTPASE-ACTIVATING
PROTEIN 2
(Homo
sapiens) 		3 / 3 ALA A 316
ASN A 319
LEU A 320
 None
 0.36A 5i1oC-5i6rA:
undetectable		 5i1oC-5i6rA:
7.14