SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 7 SER A 404
TYR A 380
TRP A 371
GLN A 417
 None
 1.32A 1eiiA-5i6vA:
undetectable		 1eiiA-5i6vA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 LEU A  77
PHE A  41
LEU A  74
THR A  73
GLY A  60
 None
 1.18A 1jffB-5i6vA:
undetectable		 1jffB-5i6vA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 9 GLN A 510
ILE A 470
ALA A 329
VAL A 457
PHE A 469
 None
 1.24A 2drdA-5i6vA:
undetectable		 2drdA-5i6vA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 LEU A  77
PHE A  41
LEU A  74
THR A  73
GLY A  60
 None
 1.18A 2hxfB-5i6vA:
undetectable		 2hxfB-5i6vA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 LEU A  77
PHE A  41
LEU A  74
THR A  73
GLY A  60
 None
 1.18A 2hxhB-5i6vA:
undetectable		 2hxhB-5i6vA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 LEU A  77
PHE A  41
LEU A  74
THR A  73
GLY A  60
 None
 1.18A 2p4nB-5i6vA:
undetectable		 2p4nB-5i6vA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		3 / 3 ASN A 277
ASN A 306
ARG A 501
 None
 0.68A 2rlcA-5i6vA:
undetectable		 2rlcA-5i6vA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 8 TYR A 515
ILE A 226
VAL A 471
LEU A 475
 None
 0.83A 2w98B-5i6vA:
undetectable		 2w98B-5i6vA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 LEU A  77
PHE A  41
LEU A  74
THR A  73
GLY A  60
 None
 1.18A 2wbeB-5i6vA:
undetectable		 2wbeB-5i6vA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 5 VAL A 518
TYR A 515
VAL A 490
ASP A 489
 None
 1.22A 2x45C-5i6vA:
undetectable		 2x45C-5i6vA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 8 VAL A 435
VAL A 457
TYR A 327
VAL A 442
 None
 1.23A 2y05A-5i6vA:
undetectable
2y05B-5i6vA:
undetectable		 2y05A-5i6vA:
21.62
2y05B-5i6vA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		3 / 3 ARG A 289
ASP A 340
ASN A 273
 None
 0.90A 2zzmA-5i6vA:
undetectable		 2zzmA-5i6vA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 LEU A  77
PHE A  41
LEU A  74
THR A  73
GLY A  60
 None
 1.18A 3dcoB-5i6vA:
undetectable		 3dcoB-5i6vA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 LEU A  77
PHE A  41
LEU A  74
THR A  73
GLY A  60
 None
 1.18A 3edlB-5i6vA:
undetectable		 3edlB-5i6vA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 GLY A 464
GLY A 467
GLN A 506
VAL A 505
ILE A 514
 None
 1.23A 3h52B-5i6vA:
undetectable		 3h52B-5i6vA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 8 ASP A 477
TYR A 521
GLY A 483
ILE A 479
 None
 0.89A 3ihzB-5i6vA:
undetectable		 3ihzB-5i6vA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 LEU A  77
PHE A  41
LEU A  74
THR A  73
GLY A  60
 None
 1.16A 3iz0B-5i6vA:
undetectable		 3iz0B-5i6vA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 ASN A 273
GLY A 268
VAL A 290
ARG A 501
LEU A 292
 None
 1.32A 3mnoA-5i6vA:
undetectable		 3mnoA-5i6vA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 ASN A 273
GLY A 268
VAL A 290
ARG A 501
LEU A 292
 None
 1.34A 3mnpA-5i6vA:
undetectable		 3mnpA-5i6vA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 MET A 355
PRO A 372
VAL A 338
CYH A 333
TYR A 380
 None
 1.49A 3p6gA-5i6vA:
undetectable		 3p6gA-5i6vA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		3 / 3 LYS A 199
GLU A 195
TRP A 112
 None
 1.46A 3v4tH-5i6vA:
undetectable		 3v4tH-5i6vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 6 THR A  59
ASN A  58
GLY A  39
ASP A  40
 None
 1.09A 3w9tE-5i6vA:
undetectable		 3w9tE-5i6vA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 8 ARG A 265
TYR A  80
GLU A  76
HIS A  84
 None
 1.36A 3zmdA-5i6vA:
undetectable
3zmdB-5i6vA:
undetectable		 3zmdA-5i6vA:
16.37
3zmdB-5i6vA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 8 LEU A 283
ARG A 265
TYR A  80
GLU A  76
 None
 1.03A 3zmdA-5i6vA:
undetectable
3zmdB-5i6vA:
undetectable		 3zmdA-5i6vA:
16.37
3zmdB-5i6vA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 7 GLY A  13
THR A  12
ILE A  11
THR A  22
 None
 0.69A 4acaC-5i6vA:
undetectable		 4acaC-5i6vA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 8 SER A 460
ASP A  61
GLU A 361
THR A 468
 None
 0.89A 4lnwA-5i6vA:
undetectable		 4lnwA-5i6vA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 12 LEU A  43
ARG A  32
GLU A 258
TYR A  81
LEU A  98
 None
 1.28A 5czyA-5i6vA:
undetectable		 5czyA-5i6vA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		5 / 11 TYR A 515
VAL A 471
ILE A 472
ILE A 479
ILE A 522
 None
 1.23A 5hw8E-5i6vA:
undetectable		 5hw8E-5i6vA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 8 TYR A 515
TYR A 511
ILE A 494
ILE A 472
 None
 0.91A 5mzrE-5i6vA:
undetectable		 5mzrE-5i6vA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 6 PHE A 341
TRP A 342
ARG A 343
GLY A 381
 None
 1.08A 5o4yF-5i6vA:
undetectable		 5o4yF-5i6vA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 5 THR A 466
THR A 288
GLN A 500
ASP A 286
 None
 1.35A 6ectA-5i6vA:
undetectable		 6ectA-5i6vA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens) 		4 / 5 THR A 466
THR A 288
GLN A 500
ASP A 286
 None
 1.39A 6ecxA-5i6vA:
undetectable		 6ecxA-5i6vA:
21.05