SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i70'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 7 LEU B 301
THR B 267
TYR B 266
LYS B 265
 None
 1.23A 1rmtB-5i70B:
undetectable		 1rmtB-5i70B:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		7 / 12 ASP B  34
GLY B  36
SER B  37
TYR B  77
ASP B 214
GLY B 216
SER B 218
 None
 0.41A 2v0zC-5i70B:
41.7		 2v0zC-5i70B:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		6 / 12 ASP B  34
GLY B  36
SER B  37
TYR B  77
PHE B 120
ASP B 214
 None
 0.68A 2v0zC-5i70B:
41.7		 2v0zC-5i70B:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_C_C41C1328_1
(RENIN)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 12 VAL B 212
ASP B 214
GLY B 216
ASP B  34
GLY B  36
 None
 0.73A 2v0zC-5i70B:
41.7		 2v0zC-5i70B:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 12 ASP B  34
GLY B  36
ASP B 214
GLY B 216
SER B 218
 None
 0.30A 2v0zO-5i70B:
41.4		 2v0zO-5i70B:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 12 ASP B  34
GLY B  36
PHE B 120
ASP B 214
SER B 218
 None
 0.69A 2v0zO-5i70B:
41.4		 2v0zO-5i70B:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0Z_O_C41O1327_1
(RENIN)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 12 VAL B 212
ASP B 214
GLY B 216
ASP B  34
GLY B  36
 None
 0.72A 2v0zO-5i70B:
41.4		 2v0zO-5i70B:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 12 VAL B 213
THR B 183
ILE B 195
SER B 261
PHE B 322
 None
 1.46A 2vdyA-5i70B:
undetectable		 2vdyA-5i70B:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 6 ASP B 214
TYR B 192
PHE B 305
LEU B 197
 None
 0.91A 2w98A-5i70B:
undetectable
2w98B-5i70B:
undetectable		 2w98A-5i70B:
23.88
2w98B-5i70B:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 12 LEU B 143
GLY B 125
ILE B 103
ASN B  39
VAL B  42
 None
 1.31A 2zznA-5i70B:
undetectable		 2zznA-5i70B:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 5 ASP B  34
ILE B 114
ILE B 123
GLY B 216
 None
 0.82A 3bufA-5i70B:
32.2		 3bufA-5i70B:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		6 / 12 ASP B  34
GLY B  36
GLY B  78
ASP B 214
THR B 217
ILE B 300
 None
 0.53A 3prsA-5i70B:
36.4		 3prsA-5i70B:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 8 GLY B  36
SER B  37
ILE B  75
TYR B  77
ASP B 214
 None
 0.59A 3pwwA-5i70B:
36.3		 3pwwA-5i70B:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		6 / 12 ASP B 214
GLY B 216
GLY B  78
ILE B 294
ASP B  34
ILE B 123
 None
 0.83A 3q70A-5i70B:
9.3		 3q70A-5i70B:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		7 / 12 ILE B  32
ASP B  34
GLY B  36
GLY B  78
ASP B 214
THR B 217
ILE B 300
 None
 0.44A 3q70A-5i70B:
9.3		 3q70A-5i70B:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		6 / 12 ILE B 123
ASP B  34
GLY B  36
ASP B 214
THR B 217
ILE B 300
 None
 1.13A 3q70A-5i70B:
9.3		 3q70A-5i70B:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		6 / 12 ASP B  34
GLY B  36
ILE B  75
GLY B  78
ASP B 214
ILE B 300
 None
 0.64A 3tneA-5i70B:
34.9		 3tneA-5i70B:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		6 / 12 ILE B  32
ASP B  34
GLY B  36
GLY B  78
ASP B 214
ILE B 300
 None
 0.50A 3tneA-5i70B:
34.9		 3tneA-5i70B:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		6 / 12 ILE B 123
ASP B  34
GLY B  36
GLY B  78
ASP B 214
ILE B 300
 None
 1.36A 3tneA-5i70B:
34.9		 3tneA-5i70B:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		6 / 12 ASP B  34
GLY B  36
ILE B  75
GLY B  78
ASP B 214
ILE B 300
 None
 0.69A 3tneB-5i70B:
34.9		 3tneB-5i70B:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		6 / 12 ILE B  32
ASP B  34
GLY B  36
GLY B  78
ASP B 214
ILE B 300
 None
 0.54A 3tneB-5i70B:
34.9		 3tneB-5i70B:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		6 / 12 ILE B 123
ASP B  34
GLY B  36
GLY B  78
ASP B 214
ILE B 300
 None
 1.34A 3tneB-5i70B:
34.9		 3tneB-5i70B:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 7 SER B  37
TYR B  77
ILE B 123
THR B 217
 None
 0.69A 3tneB-5i70B:
34.9		 3tneB-5i70B:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 12 LEU B 191
GLY B  36
ILE B 300
VAL B 212
ALA B  38
 None
 0.87A 4a6dA-5i70B:
undetectable		 4a6dA-5i70B:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 12 LEU B 191
GLY B  36
ILE B 300
VAL B 212
ALA B  38
 None
 0.90A 4a6eA-5i70B:
undetectable		 4a6eA-5i70B:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 6 TRP B 193
ILE B 195
VAL B 312
SER B 261
 None
 1.07A 4iaqA-5i70B:
undetectable		 4iaqA-5i70B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		4 / 8 ASN B 188
ASP B 214
ASN B 210
ILE B 294
 None
 1.06A 4l7iA-5i70B:
undetectable		 4l7iA-5i70B:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 11 GLY B 171
GLY B 172
ALA B 152
LEU B 153
GLU B 316
 None
 1.17A 4l8fB-5i70B:
undetectable		 4l8fB-5i70B:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 11 GLY B 171
GLY B 172
ALA B 152
LEU B 153
GLU B 316
 None
 1.17A 4l8fD-5i70B:
undetectable		 4l8fD-5i70B:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		3 / 3 ASP B 214
ASP B  34
ASN B  39
 None
 0.47A 4q5mA-5i70B:
10.1		 4q5mA-5i70B:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		5 / 12 LEU B  93
GLY B 216
ILE B 170
PHE B 154
GLY B  36
 None
 1.06A 5veuH-5i70B:
undetectable		 5veuH-5i70B:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5i70 PLASMEPSIN IV
(Plasmodium
falciparum) 		3 / 3 GLY B 117
VAL B  11
MET B  15
 None
 0.61A 5ycpA-5i70B:
undetectable		 5ycpA-5i70B:
11.89