SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		5 / 10 MET A 283
GLN A 226
VAL A 249
ILE A 265
GLY A 199
 None
PGE  A 402 (-3.5A)
None
None
PGE  A 402 ( 3.9A)
 1.49A 1fohA-5i77A:
undetectable		 1fohA-5i77A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		5 / 12 GLY A  36
ALA A 301
PHE A  74
LEU A 116
PHE A 264
 None
 1.34A 1nw3A-5i77A:
undetectable		 1nw3A-5i77A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		4 / 7 TRP A 140
GLY A 184
GLN A 146
PHE A 155
 None
 0.88A 2qwxA-5i77A:
undetectable
2qwxB-5i77A:
undetectable		 2qwxA-5i77A:
20.38
2qwxB-5i77A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		5 / 12 ASN A 159
GLU A 160
HIS A 225
GLU A 267
TRP A 300
 None
PEG  A 403 ( 2.7A)
None
PEG  A 403 (-2.9A)
PEG  A 403 ( 4.1A)
 0.60A 2v3dA-5i77A:
8.4		 2v3dA-5i77A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		5 / 12 ARG A  76
GLU A 193
TYR A 227
ASN A 159
HIS A 120
 None
None
PEG  A 403 ( 4.6A)
None
None
 1.46A 3bjmB-5i77A:
undetectable		 3bjmB-5i77A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		4 / 7 GLU A  82
TYR A  97
PHE A 139
TYR A 125
 None
 1.36A 3ku9B-5i77A:
undetectable		 3ku9B-5i77A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		5 / 12 HIS A 120
PHE A  44
GLY A 303
ALA A 302
LEU A 313
 None
PEG  A 404 (-3.4A)
None
None
None
 1.24A 3n8xA-5i77A:
undetectable		 3n8xA-5i77A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		5 / 9 LEU A 328
LEU A 313
ILE A  68
PHE A  35
GLU A  39
 None
 1.06A 3tmzA-5i77A:
undetectable		 3tmzA-5i77A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		5 / 12 ARG A  76
GLU A 193
TYR A 227
ASN A 159
HIS A 120
 None
None
PEG  A 403 ( 4.6A)
None
None
 1.46A 3w2tA-5i77A:
undetectable		 3w2tA-5i77A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		5 / 12 ARG A  76
GLU A 193
TYR A 227
ASN A 159
HIS A 120
 None
None
PEG  A 403 ( 4.6A)
None
None
 1.43A 3w2tB-5i77A:
undetectable		 3w2tB-5i77A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		3 / 3 ASN A  38
TRP A 300
ASP A 156
 None
PEG  A 403 ( 4.1A)
None
 1.27A 4a7tA-5i77A:
undetectable
4a7tF-5i77A:
undetectable		 4a7tA-5i77A:
20.00
4a7tF-5i77A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		4 / 7 ASN A  38
ARG A  76
GLN A  78
GLU A  43
 None
 1.30A 4mv7A-5i77A:
undetectable		 4mv7A-5i77A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		4 / 6 LEU A 172
ASN A 173
MET A  89
ILE A 190
 None
 1.12A 4okxA-5i77A:
undetectable		 4okxA-5i77A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		5 / 12 LEU A  84
GLY A  91
PHE A 136
THR A 133
TYR A 125
 None
 1.47A 5d0yA-5i77A:
undetectable		 5d0yA-5i77A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		3 / 3 THR A 198
GLU A 193
HIS A 120
 None
 0.79A 5xioA-5i77A:
undetectable		 5xioA-5i77A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		3 / 3 THR A 198
GLU A 193
HIS A 120
 None
 0.80A 5xiqB-5i77A:
undetectable		 5xiqB-5i77A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		3 / 3 THR A 198
GLU A 193
HIS A 120
 None
 0.82A 5xiqD-5i77A:
undetectable		 5xiqD-5i77A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		5 / 12 ARG A  76
GLU A 193
TYR A 227
ASN A 159
HIS A 120
 None
None
PEG  A 403 ( 4.6A)
None
None
 1.44A 6b1eB-5i77A:
undetectable		 6b1eB-5i77A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 5i77 ENDO-BETA-1,
4-GLUCANASE
(Aspergillus
niger) 		5 / 12 TRP A 300
PHE A  75
ALA A 302
TYR A 309
VAL A 104
 PEG  A 403 ( 4.1A)
None
None
None
None
 1.26A 6hu9N-5i77A:
undetectable		 6hu9N-5i77A:
19.90