SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1
(Homo
sapiens) 		6 / 11 LEU A 226
ASP A 158
VAL A 219
GLY A 136
THR A  67
VAL A 223
 None
 1.13A 1t7jA-5i7kA:
undetectable		 1t7jA-5i7kA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1
(Homo
sapiens) 		5 / 11 LEU A  55
LEU A 118
ILE A 242
THR A 160
VAL A 253
 None
 1.30A 2qd3A-5i7kA:
undetectable		 2qd3A-5i7kA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1
(Homo
sapiens) 		5 / 12 ASP A 158
VAL A 219
GLY A 136
THR A  67
VAL A 223
 None
 0.92A 3el5B-5i7kA:
undetectable		 3el5B-5i7kA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1
(Homo
sapiens) 		5 / 12 ALA A 161
LEU A  55
LEU A 120
ILE A 242
THR A 160
 None
 1.15A 3hj3A-5i7kA:
undetectable		 3hj3A-5i7kA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1
(Homo
sapiens) 		5 / 11 ALA A 161
LEU A  55
LEU A 120
ILE A 242
THR A 160
 None
 1.14A 3jw5A-5i7kA:
undetectable		 3jw5A-5i7kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1
(Homo
sapiens) 		5 / 10 ALA A 161
LEU A  55
LEU A 120
ILE A 242
THR A 160
 None
 1.14A 3jw5B-5i7kA:
undetectable		 3jw5B-5i7kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1
(Homo
sapiens) 		6 / 11 ALA A 161
LEU A  55
LEU A 120
ILE A 242
LEU A 246
THR A 160
 None
 1.34A 3tqbA-5i7kA:
undetectable		 3tqbA-5i7kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A  55
LEU A 118
ILE A 242
THR A 160
VAL A 253
 None
 1.26A 4f4dA-5i7kA:
undetectable		 4f4dA-5i7kA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1
(Homo
sapiens) 		5 / 12 LEU A 175
LEU A 129
LEU A 164
GLY A 249
HIS A 248
 None
 1.25A 4j26A-5i7kA:
undetectable		 4j26A-5i7kA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1
(Homo
sapiens) 		4 / 4 LEU A 211
SER A 206
LEU A 151
LEU A  73
 None
 1.07A 4n09A-5i7kA:
undetectable		 4n09A-5i7kA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1
(Homo
sapiens) 		5 / 12 PRO A  72
LEU A  73
GLY A 221
PRO A 225
LEU A 226
 None
 1.29A 5emlA-5i7kA:
undetectable		 5emlA-5i7kA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1
(Homo
sapiens) 		5 / 10 LEU A  51
GLY A  49
GLY A  46
LEU A 234
ALA A  54
 None
 1.08A 5o96G-5i7kA:
undetectable
5o96H-5i7kA:
undetectable		 5o96G-5i7kA:
19.64
5o96H-5i7kA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1
(Homo
sapiens) 		4 / 7 LEU A 234
VAL A 131
LEU A  55
LEU A  59
 None
 0.69A 6g9bA-5i7kA:
undetectable
6g9bB-5i7kA:
undetectable		 6g9bA-5i7kA:
14.29
6g9bB-5i7kA:
15.62