SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5i7m DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		4 / 4 THR A 363
LEU A 311
LEU A 291
GLN A 290
 None
 1.17A 1fbmA-5i7mA:
undetectable		 1fbmA-5i7mA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5i7m DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		3 / 3 HIS A 300
ASP A 380
ASN A 374
 None
 0.87A 1wg8B-5i7mA:
undetectable		 1wg8B-5i7mA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5i7m DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		4 / 4 ILE A 316
LEU A 313
LYS A 314
ASN A 445
 None
 1.02A 4g19D-5i7mA:
undetectable		 4g19D-5i7mA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 5i7m DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens) 		4 / 8 GLN A 446
GLY A 438
ILE A 454
ASP A 435
 None
 0.98A 5vlmH-5i7mA:
undetectable		 5vlmH-5i7mA:
21.88