SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i7n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		5 / 9 LEU A 266
ILE A 302
VAL A 294
GLY A 299
ALA A 292
 None
 0.97A 1e7aA-5i7nA:
undetectable		 1e7aA-5i7nA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		4 / 8 ALA A 135
GLU A 137
ASP A 105
ILE A 101
 None
 0.92A 1p7lD-5i7nA:
undetectable		 1p7lD-5i7nA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		4 / 8 ALA A 135
GLU A 137
ASP A 105
ILE A 101
 None
 0.92A 1p7lC-5i7nA:
undetectable		 1p7lC-5i7nA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		4 / 8 ALA A 135
GLU A 137
ASP A 105
ILE A 101
 None
 0.92A 1rg9B-5i7nA:
undetectable		 1rg9B-5i7nA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		4 / 8 ALA A 135
GLU A 137
ASP A 105
ILE A 101
 None
 0.92A 1rg9A-5i7nA:
undetectable		 1rg9A-5i7nA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		4 / 8 ALA A 135
GLU A 137
ASP A 105
ILE A 101
 None
 0.93A 1rg9D-5i7nA:
undetectable		 1rg9D-5i7nA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		4 / 8 ALA A 135
GLU A 137
ASP A 105
ILE A 101
 None
 0.93A 1rg9C-5i7nA:
undetectable		 1rg9C-5i7nA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		4 / 6 LEU A  89
ALA A 251
HIS A 242
ASP A 237
 None
 1.29A 2dpzA-5i7nA:
undetectable		 2dpzA-5i7nA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		5 / 12 PHE A 271
GLY A 267
GLY A 269
LEU A  63
PHE A 332
 None
 1.09A 2zulA-5i7nA:
undetectable		 2zulA-5i7nA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		4 / 6 ALA A 248
ILE A 241
VAL A 162
ASN A 239
 None
 1.17A 3nneG-5i7nA:
undetectable		 3nneG-5i7nA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		4 / 5 ARG A 225
LEU A 228
PRO A 240
ASP A 255
 None
 1.14A 3ufnA-5i7nA:
undetectable
3ufnB-5i7nA:
undetectable		 3ufnA-5i7nA:
20.15
3ufnB-5i7nA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		4 / 8 ALA A 135
GLU A 137
ASP A 105
ILE A 101
 None
 0.92A 4ndnB-5i7nA:
undetectable		 4ndnB-5i7nA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		4 / 8 VAL A 339
LEU A  54
GLY A 203
SER A 275
 None
 0.79A 5f1aA-5i7nA:
undetectable		 5f1aA-5i7nA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		4 / 8 GLY A  84
ARG A 118
ASP A 123
ASP A 152
 None
 1.00A 5vlmB-5i7nA:
undetectable		 5vlmB-5i7nA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		5 / 12 VAL A  31
GLN A  97
GLY A  58
ALA A 103
LEU A 107
 None
 1.02A 5xxiA-5i7nA:
undetectable		 5xxiA-5i7nA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		5 / 12 PHE A 341
SER A 310
VAL A 212
ARG A 316
ASP A 208
 None
 1.45A 6bxnA-5i7nA:
undetectable		 6bxnA-5i7nA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5i7n MAOC-LIKE
DEHYDRATASE
(Mycobacteroides
abscessus) 		4 / 5 TYR A 284
VAL A 212
PHE A 304
GLY A 269
 None
 1.34A 6hd4A-5i7nA:
undetectable		 6hd4A-5i7nA:
13.14