SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 ALA A 524
GLY A 245
TRP A 244
LEU A 207
LEU A 261
 None
 0.87A 1eizA-5i85A:
undetectable		 1eizA-5i85A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 ALA A 524
GLY A 245
TRP A 244
LEU A 207
LEU A 261
 None
 0.88A 1ej0A-5i85A:
2.2		 1ej0A-5i85A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 ASP A 278
HIS A 319
HIS A 208
 ZN  A 714 (-2.6A)
PC  A 727 (-3.7A)
ZN  A 715 ( 3.4A)
 0.64A 1oe1A-5i85A:
undetectable		 1oe1A-5i85A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 ASP A 278
HIS A 319
HIS A 208
 ZN  A 714 (-2.6A)
PC  A 727 (-3.7A)
ZN  A 715 ( 3.4A)
 0.63A 1oe3A-5i85A:
undetectable		 1oe3A-5i85A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 ARG A 496
VAL A 478
TRP A 553
 None
 1.27A 1qw6A-5i85A:
undetectable		 1qw6A-5i85A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 TYR A 213
ASP A 251
ASP A 210
HIS A 286
 None
 1.10A 1t03A-5i85A:
undetectable		 1t03A-5i85A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 LEU A 481
PRO A 427
GLY A 317
ASP A 278
 None
None
None
ZN  A 714 (-2.6A)
 0.92A 2ddwB-5i85A:
2.1		 2ddwB-5i85A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1290_1
(FICOLIN-2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 9 SER A 436
SER A 603
LEU A 606
LEU A 472
GLU A 469
 None
 1.27A 2j2pD-5i85A:
undetectable
2j2pE-5i85A:
undetectable		 2j2pD-5i85A:
16.58
2j2pE-5i85A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 6 LEU A 535
PHE A 270
ASP A 271
GLU A 515
 None
None
SO4  A 726 (-4.0A)
None
 1.09A 2vn1B-5i85A:
undetectable		 2vn1B-5i85A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 ASP A 278
HIS A 319
HIS A 208
 ZN  A 714 (-2.6A)
PC  A 727 (-3.7A)
ZN  A 715 ( 3.4A)
 0.66A 2xxgA-5i85A:
undetectable		 2xxgA-5i85A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 ASP A 278
HIS A 319
HIS A 208
 ZN  A 714 (-2.6A)
PC  A 727 (-3.7A)
ZN  A 715 ( 3.4A)
 0.67A 2xxgC-5i85A:
undetectable		 2xxgC-5i85A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 6 GLY A 242
GLU A 246
GLY A 240
ASN A 525
 None
 1.01A 3e9rA-5i85A:
undetectable		 3e9rA-5i85A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 6 GLY A 242
GLU A 246
GLY A 240
ASN A 525
 None
 1.00A 3e9rC-5i85A:
undetectable		 3e9rC-5i85A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 LEU A 410
PRO A 428
GLY A 424
MET A 382
 None
 0.92A 3hcnA-5i85A:
undetectable		 3hcnA-5i85A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 5 GLY A 240
GLU A 246
GLY A 216
PRO A 219
 None
 1.01A 3onnA-5i85A:
undetectable		 3onnA-5i85A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 ASN A 325
ASP A 206
HIS A 459
HIS A 208
 None
ZN  A 715 ( 3.1A)
ZN  A 715 ( 3.3A)
ZN  A 715 ( 3.4A)
 0.98A 3t01A-5i85A:
undetectable		 3t01A-5i85A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 HIS A 509
HIS A 421
ILE A 500
 None
 0.77A 3u52A-5i85A:
undetectable
3u52C-5i85A:
undetectable		 3u52A-5i85A:
20.10
3u52C-5i85A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 GLN A 453
PHE A 466
TYR A 439
 None
 0.83A 3ucjB-5i85A:
undetectable		 3ucjB-5i85A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 GLN A 453
PHE A 466
TYR A 439
 None
 0.81A 3ucjA-5i85A:
undetectable		 3ucjA-5i85A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 HIS A 319
GLU A 320
ASN A 383
 PC  A 727 (-3.7A)
None
None
 1.01A 4bupB-5i85A:
undetectable		 4bupB-5i85A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 8 ASP A 278
ASP A 141
ASN A 318
GLU A 320
 ZN  A 714 (-2.6A)
None
ZN  A 714 ( 2.6A)
None
 1.12A 4feuD-5i85A:
undetectable		 4feuD-5i85A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 7 HIS A 421
ILE A 423
TYR A 313
PRO A 371
 None
 1.16A 4g5jA-5i85A:
undetectable		 4g5jA-5i85A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		6 / 12 VAL A 273
LEU A 264
LEU A 307
VAL A 312
THR A 300
TRP A 352
 None
 1.26A 4k13A-5i85A:
undetectable		 4k13A-5i85A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 SER A 199
TYR A 372
PRO A 269
 None
NAG  A 711 (-4.6A)
None
 0.96A 4k8cA-5i85A:
2.6		 4k8cA-5i85A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 SER A 199
TYR A 372
PRO A 269
 None
NAG  A 711 (-4.6A)
None
 0.94A 4kahA-5i85A:
2.6		 4kahA-5i85A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 SER A 199
TYR A 372
PRO A 269
 None
NAG  A 711 (-4.6A)
None
 0.94A 4kahB-5i85A:
2.4		 4kahB-5i85A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 SER A 199
TYR A 372
PRO A 269
 None
NAG  A 711 (-4.6A)
None
 0.95A 4kbeA-5i85A:
2.5		 4kbeA-5i85A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 SER A 199
TYR A 372
PRO A 269
 None
NAG  A 711 (-4.6A)
None
 0.95A 4kbeB-5i85A:
2.3		 4kbeB-5i85A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 SER A 199
TYR A 372
PRO A 269
 None
NAG  A 711 (-4.6A)
None
 0.96A 4lbgA-5i85A:
undetectable		 4lbgA-5i85A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 SER A 199
TYR A 372
PRO A 269
 None
NAG  A 711 (-4.6A)
None
 0.95A 4lbgB-5i85A:
2.4		 4lbgB-5i85A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 5 TYR A 274
PRO A 314
LEU A 369
TYR A 367
 None
 1.28A 4w5qA-5i85A:
2.6		 4w5qA-5i85A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 6 TYR A 274
PRO A 314
LEU A 369
TYR A 367
 None
 1.24A 4z4cA-5i85A:
undetectable		 4z4cA-5i85A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 5 ALA A 344
HIS A 457
PRO A 280
PHE A 327
 None
ZN  A 714 (-3.2A)
None
None
 1.30A 4ze2A-5i85A:
undetectable		 4ze2A-5i85A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 HIS A 208
ASP A 278
LEU A 341
PHE A 327
HIS A 425
 ZN  A 715 ( 3.4A)
ZN  A 714 (-2.6A)
None
None
ZN  A 714 (-3.2A)
 1.34A 5dv4A-5i85A:
4.3		 5dv4A-5i85A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 LEU A 369
GLY A 364
GLY A 365
ALA A 357
LEU A 353
 None
 1.04A 5kb5A-5i85A:
2.1		 5kb5A-5i85A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 HIS A 459
HIS A 319
HIS A 282
HIS A 208
 ZN  A 715 ( 3.3A)
PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.89A 5mhwA-5i85A:
undetectable		 5mhwA-5i85A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 HIS A 459
HIS A 319
HIS A 282
HIS A 208
 ZN  A 715 ( 3.3A)
PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.89A 5mhxA-5i85A:
undetectable		 5mhxA-5i85A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 HIS A 459
HIS A 319
HIS A 282
HIS A 208
 ZN  A 715 ( 3.3A)
PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.89A 5mhyA-5i85A:
undetectable		 5mhyA-5i85A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 HIS A 459
HIS A 319
HIS A 282
HIS A 208
 ZN  A 715 ( 3.3A)
PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.90A 5mhzA-5i85A:
undetectable		 5mhzA-5i85A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 HIS A 459
HIS A 319
HIS A 282
HIS A 208
 ZN  A 715 ( 3.3A)
PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.90A 5mi1A-5i85A:
undetectable		 5mi1A-5i85A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 HIS A 459
HIS A 319
HIS A 282
HIS A 208
 ZN  A 715 ( 3.3A)
PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.90A 5mi2A-5i85A:
undetectable		 5mi2A-5i85A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 HIS A 459
HIS A 319
HIS A 282
HIS A 208
 ZN  A 715 ( 3.3A)
PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.91A 5miaA-5i85A:
undetectable		 5miaA-5i85A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 HIS A 459
HIS A 319
HIS A 282
HIS A 208
 ZN  A 715 ( 3.3A)
PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.91A 5mibA-5i85A:
undetectable		 5mibA-5i85A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 HIS A 459
HIS A 319
HIS A 282
HIS A 208
 ZN  A 715 ( 3.3A)
PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.91A 5micA-5i85A:
undetectable		 5micA-5i85A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 HIS A 459
HIS A 319
HIS A 282
HIS A 208
 ZN  A 715 ( 3.3A)
PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.90A 5midA-5i85A:
undetectable		 5midA-5i85A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 HIS A 459
HIS A 319
HIS A 282
HIS A 208
 ZN  A 715 ( 3.3A)
PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.91A 5mieA-5i85A:
undetectable		 5mieA-5i85A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 ASP A 278
HIS A 425
HIS A 457
HIS A 319
 ZN  A 714 (-2.6A)
ZN  A 714 (-3.2A)
ZN  A 714 (-3.2A)
PC  A 727 (-3.7A)
 1.49A 5ncdD-5i85A:
undetectable		 5ncdD-5i85A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 12 LEU A 519
GLY A 494
GLU A 258
LEU A 261
LEU A 264
 None
 1.21A 5nwvA-5i85A:
undetectable		 5nwvA-5i85A:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		4 / 4 LEU A 353
LEU A 369
SER A 379
ALA A 368
 None
 1.09A 5uunA-5i85A:
undetectable		 5uunA-5i85A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 HIS A 319
GLU A 320
ASN A 383
 PC  A 727 (-3.7A)
None
None
 0.95A 5wbvA-5i85A:
undetectable		 5wbvA-5i85A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 HIS A 319
GLU A 320
ASN A 383
 PC  A 727 (-3.7A)
None
None
 0.94A 5wbvB-5i85A:
2.2		 5wbvB-5i85A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		3 / 3 HIS A 319
HIS A 282
HIS A 208
 PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.75A 6giqa-5i85A:
undetectable		 6giqa-5i85A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens) 		5 / 9 ILE A 426
GLY A 317
GLY A 364
TYR A 342
ASN A 383
 SO4  A 716 ( 4.8A)
None
None
None
None
 1.28A 6nm4B-5i85A:
undetectable		 6nm4B-5i85A:
17.24