SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i8e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 5i8e VRC34.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 ALA A 136
VAL A 184
LEU A 138
GLU A 212
ALA A 125
 None
 1.00A 1sn5B-5i8eA:
3.6
1sn5D-5i8eA:
undetectable		 1sn5B-5i8eA:
20.78
1sn5D-5i8eA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 5i8e VRC34.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 LEU A 138
GLU A 212
ALA A 125
ALA A 136
VAL A 184
 None
 1.01A 1sn5B-5i8eA:
3.6
1sn5D-5i8eA:
undetectable		 1sn5B-5i8eA:
20.78
1sn5D-5i8eA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5i8e VRC34.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL A 163
VAL A 182
SER A 180
ASN A 197
ASN A 155
 None
 1.37A 2y03A-5i8eA:
undetectable		 2y03A-5i8eA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 5i8e VRC34.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL A 163
VAL A 182
SER A 180
ASN A 197
ASN A 155
 None
 1.42A 3nyaA-5i8eA:
undetectable		 3nyaA-5i8eA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5i8e VRC34.01 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 6 ASN A  76
ALA A  24
PRO A  52
TYR A  27
 None
 0.97A 5umd2-5i8eA:
undetectable
5umdF-5i8eA:
undetectable		 5umd2-5i8eA:
20.09
5umdF-5i8eA:
16.67