SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 5i8g CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 7 SER A1136
ASP A1134
SER A1108
LEU A1098
 None
None
None
PEG  A1413 (-3.7A)
 1.06A 2cdqB-5i8gA:
undetectable		 2cdqB-5i8gA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5i8g CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 7 PRO A1110
VAL A1115
LEU A1120
ASN A1168
 69E  A1404 (-3.7A)
69E  A1404 (-4.3A)
69E  A1404 (-4.2A)
69E  A1404 (-3.0A)
 0.56A 3u5kB-5i8gA:
16.1		 3u5kB-5i8gA:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 5i8g CREB-BINDING PROTEIN
(Homo
sapiens) 		6 / 6 VAL A1115
LEU A1120
ILE A1122
TYR A1167
ASN A1168
VAL A1174
 69E  A1404 (-4.3A)
69E  A1404 (-4.2A)
69E  A1404 ( 4.7A)
69E  A1404 (-4.8A)
69E  A1404 (-3.0A)
69E  A1404 (-4.8A)
 0.82A 4a9kA-5i8gA:
18.8		 4a9kA-5i8gA:
88.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 5i8g CREB-BINDING PROTEIN
(Homo
sapiens) 		5 / 5 VAL A1115
LEU A1120
ILE A1122
ASN A1168
VAL A1174
 69E  A1404 (-4.3A)
69E  A1404 (-4.2A)
69E  A1404 ( 4.7A)
69E  A1404 (-3.0A)
69E  A1404 (-4.8A)
 0.39A 4a9kB-5i8gA:
19.1		 4a9kB-5i8gA:
88.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5i8g CREB-BINDING PROTEIN
(Homo
sapiens) 		5 / 9 PRO A1110
GLN A1113
VAL A1115
LEU A1120
ASN A1168
 69E  A1404 (-3.7A)
69E  A1404 (-3.4A)
69E  A1404 (-4.3A)
69E  A1404 (-4.2A)
69E  A1404 (-3.0A)
 0.75A 4c66A-5i8gA:
16.2		 4c66A-5i8gA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5i8g CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 6 ALA A1093
GLN A1092
LEU A1094
MET A1095
 None
None
None
PEG  A1413 ( 4.2A)
 1.27A 4xp3A-5i8gA:
undetectable		 4xp3A-5i8gA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5i8g CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 6 VAL A1295
CYH A1308
CYH A1283
HIS A1291
 None
ZN  A1402 (-2.3A)
ZN  A1402 (-2.3A)
ZN  A1401 (-3.1A)
 1.38A 5hrqH-5i8gA:
undetectable
5hrqK-5i8gA:
undetectable
5hrqL-5i8gA:
undetectable		 5hrqH-5i8gA:
6.04
5hrqK-5i8gA:
7.81
5hrqL-5i8gA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5i8g CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 6 PRO A1110
VAL A1115
TYR A1125
ASN A1168
 69E  A1404 (-3.7A)
69E  A1404 (-4.3A)
69E  A1404 (-4.8A)
69E  A1404 (-3.0A)
 0.46A 5pbeA-5i8gA:
15.8		 5pbeA-5i8gA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5i8g CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 8 PRO A1110
VAL A1115
LEU A1120
TYR A1167
 69E  A1404 (-3.7A)
69E  A1404 (-4.3A)
69E  A1404 (-4.2A)
69E  A1404 (-4.8A)
 0.60A 5y1yA-5i8gA:
16.1		 5y1yA-5i8gA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5i8g CREB-BINDING PROTEIN
(Homo
sapiens) 		4 / 8 VAL A1115
LEU A1120
TYR A1167
ASN A1168
 69E  A1404 (-4.3A)
69E  A1404 (-4.2A)
69E  A1404 (-4.8A)
69E  A1404 (-3.0A)
 0.23A 5y1yA-5i8gA:
16.1		 5y1yA-5i8gA:
22.75