SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 ALA A1319
GLY A1479
GLY A1347
GLY A1348
LEU A1484
 None
 0.94A 1eizA-5i8iA:
4.3		 1eizA-5i8iA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 ALA A1319
GLY A1479
GLY A1347
GLY A1348
LEU A1484
 None
 0.93A 1ej0A-5i8iA:
4.1		 1ej0A-5i8iA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 ALA A1592
PHE A1577
VAL A1579
VAL A1669
 None
 0.55A 1epbB-5i8iA:
undetectable		 1epbB-5i8iA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 ARG A1610
SER A1609
GLY A1635
ASN A1330
PHE A1349
 None
 1.44A 1ho5A-5i8iA:
undetectable		 1ho5A-5i8iA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 10 ARG A1610
SER A1609
GLY A1635
ASN A1330
PHE A1349
 None
 1.46A 1ho5B-5i8iA:
undetectable		 1ho5B-5i8iA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 9 LEU A 443
LEU A 255
ILE A 370
THR A 429
ILE A 431
 None
 1.44A 1hzeA-5i8iA:
undetectable
1hzeB-5i8iA:
undetectable		 1hzeA-5i8iA:
4.55
1hzeB-5i8iA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 9 THR A 429
ILE A 431
LEU A 443
LEU A 255
ILE A 370
 None
 1.43A 1hzeA-5i8iA:
undetectable
1hzeB-5i8iA:
undetectable		 1hzeA-5i8iA:
4.55
1hzeB-5i8iA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 10 ASP A 474
LEU A 473
ILE A 188
THR A 468
ILE A 467
 None
 1.30A 1i18A-5i8iA:
2.3
1i18B-5i8iA:
2.3		 1i18A-5i8iA:
4.55
1i18B-5i8iA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 10 THR A 468
ILE A 467
ASP A 474
LEU A 473
ILE A 188
 None
 1.30A 1i18A-5i8iA:
2.3
1i18B-5i8iA:
2.3		 1i18A-5i8iA:
4.55
1i18B-5i8iA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 6 TYR A1379
VAL A1474
ILE A1473
LEU A1418
 None
 0.93A 1j96A-5i8iA:
undetectable		 1j96A-5i8iA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 GLN A1638
GLY A1619
GLY A1621
ILE A1557
GLY A1641
 None
 1.03A 1jg3A-5i8iA:
3.0		 1jg3A-5i8iA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 GLN A1638
GLY A1619
GLY A1621
ILE A1557
GLY A1641
 None
 1.00A 1jg3B-5i8iA:
4.0		 1jg3B-5i8iA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 ILE A1213
PRO A1130
LEU A1123
ASN A 965
VAL A 967
 None
 1.29A 1mrlA-5i8iA:
undetectable
1mrlB-5i8iA:
undetectable		 1mrlA-5i8iA:
7.39
1mrlB-5i8iA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 TYR A1209
PRO A1130
LEU A1123
ASN A 965
VAL A 967
 None
 1.26A 1mrlA-5i8iA:
undetectable
1mrlB-5i8iA:
undetectable		 1mrlA-5i8iA:
7.39
1mrlB-5i8iA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 THR A 193
ASN A 406
LEU A 209
GLU A 312
 None
 1.20A 1mxgA-5i8iA:
undetectable		 1mxgA-5i8iA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 ARG A1439
TYR A1379
SER A1104
TYR A1085
 None
 1.25A 1nx9B-5i8iA:
3.1		 1nx9B-5i8iA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 ARG A1296
GLU A1335
SER A1317
ASN A1318
ILE A1735
 None
 1.45A 1odiB-5i8iA:
undetectable		 1odiB-5i8iA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 ARG A1296
GLU A1335
SER A1317
ASN A1318
ILE A1735
 None
 1.45A 1odiC-5i8iA:
undetectable		 1odiC-5i8iA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 ARG A1296
GLU A1335
SER A1317
ASN A1318
ILE A1735
 None
 1.46A 1odiF-5i8iA:
undetectable		 1odiF-5i8iA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P5Z_B_AR3B304_1
(DEOXYCYTIDINE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 GLU A 923
VAL A 931
LEU A 915
TYR A 704
ARG A 987
 None
 1.43A 1p5zB-5i8iA:
undetectable		 1p5zB-5i8iA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 10 SER A1698
VAL A1695
GLU A1696
SER A1518
ASP A1667
 None
 1.42A 1pk7C-5i8iA:
undetectable		 1pk7C-5i8iA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 10 SER A1698
VAL A1695
GLU A1696
SER A1518
ASP A1667
 None
 1.38A 1pk9A-5i8iA:
undetectable		 1pk9A-5i8iA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 SER A 177
GLY A 171
VAL A 212
SER A 154
ILE A  82
 None
 1.06A 1pk9C-5i8iA:
undetectable		 1pk9C-5i8iA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 9 SER A1698
VAL A1695
GLU A1696
SER A1518
ASP A1667
 None
 1.41A 1pw7C-5i8iA:
undetectable		 1pw7C-5i8iA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 LEU A1170
GLY A1187
GLY A1188
ILE A1189
ILE A1140
 None
 1.01A 1sduA-5i8iA:
undetectable		 1sduA-5i8iA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 SER A 177
GLY A 171
VAL A 212
ILE A  82
ARG A 313
 None
 1.05A 1vhwA-5i8iA:
undetectable
1vhwD-5i8iA:
undetectable		 1vhwA-5i8iA:
9.08
1vhwD-5i8iA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 SER A 177
GLY A 171
VAL A 212
ILE A  82
ARG A 313
 None
 1.04A 1vhwC-5i8iA:
undetectable
1vhwE-5i8iA:
undetectable		 1vhwC-5i8iA:
9.08
1vhwE-5i8iA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 ARG A 313
SER A 177
GLY A 171
VAL A 212
ILE A  82
 None
 1.06A 1vhwA-5i8iA:
undetectable
1vhwD-5i8iA:
undetectable		 1vhwA-5i8iA:
9.08
1vhwD-5i8iA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 ARG A 313
SER A 177
GLY A 171
VAL A 212
ILE A  82
 None
 1.06A 1vhwC-5i8iA:
undetectable
1vhwE-5i8iA:
undetectable		 1vhwC-5i8iA:
9.08
1vhwE-5i8iA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		3 / 3 ALA A 155
VAL A 160
TRP A  44
 None
 0.87A 1w5uC-5i8iA:
undetectable
1w5uD-5i8iA:
undetectable		 1w5uC-5i8iA:
0.95
1w5uD-5i8iA:
0.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 LEU A1222
ALA A1122
LEU A1214
LEU A1132
THR A1138
 None
 1.32A 1ya3B-5i8iA:
undetectable		 1ya3B-5i8iA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 GLN A 916
MET A 834
VAL A 895
MET A 934
ILE A 937
 None
 1.14A 1z95A-5i8iA:
undetectable		 1z95A-5i8iA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 4 VAL A 917
LEU A1061
ILE A1045
LEU A1042
 None
 1.03A 2byoA-5i8iA:
0.9		 2byoA-5i8iA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 ALA A 155
ASP A 124
GLY A 152
GLY A 151
 None
 0.71A 2c49B-5i8iA:
4.0		 2c49B-5i8iA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		3 / 3 ALA A 155
THR A 140
PHE A 215
 None
 0.70A 2c6nB-5i8iA:
undetectable		 2c6nB-5i8iA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 PHE A1374
VAL A1363
LEU A1360
GLY A1294
TYR A1275
 None
 1.18A 2cbrA-5i8iA:
undetectable		 2cbrA-5i8iA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 GLY A1621
GLY A1313
GLN A1638
THR A1604
CYH A1626
 None
 1.49A 2dr2A-5i8iA:
3.4		 2dr2A-5i8iA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 VAL A 538
GLY A 543
THR A 601
ILE A 546
THR A 515
 None
 1.27A 2f9wA-5i8iA:
undetectable
2f9wB-5i8iA:
undetectable		 2f9wA-5i8iA:
9.84
2f9wB-5i8iA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 6 ASN A1318
HIS A1315
ILE A1557
GLN A1638
 None
 1.21A 2hkkA-5i8iA:
undetectable		 2hkkA-5i8iA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 SER A 213
SER A 169
VAL A 214
SER A 154
 None
 1.49A 2j9cA-5i8iA:
0.0
2j9cB-5i8iA:
1.3
2j9cC-5i8iA:
0.3		 2j9cA-5i8iA:
5.24
2j9cB-5i8iA:
5.24
2j9cC-5i8iA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 6 GLY A 579
PRO A 513
LYS A 514
THR A 515
 None
 1.21A 2m2oB-5i8iA:
undetectable		 2m2oB-5i8iA:
2.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 GLU A 923
VAL A 931
LEU A 915
TYR A 704
ARG A 987
 None
 1.48A 2no0B-5i8iA:
undetectable		 2no0B-5i8iA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 LEU A1222
ALA A1122
LEU A1214
LEU A1132
THR A1138
 None
 1.32A 2oaxC-5i8iA:
undetectable		 2oaxC-5i8iA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		3 / 3 ARG A 632
SER A 661
TYR A 682
 None
 1.06A 2q2hA-5i8iA:
undetectable
2q2hB-5i8iA:
1.2		 2q2hA-5i8iA:
6.23
2q2hB-5i8iA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		3 / 3 VAL A1554
ASP A1555
GLU A1528
 None
 0.35A 2qeuA-5i8iA:
undetectable		 2qeuA-5i8iA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		3 / 3 VAL A1554
ASP A1555
GLU A1528
 None
 0.37A 2qeuC-5i8iA:
undetectable		 2qeuC-5i8iA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 GLY A1263
GLN A1352
PHE A1280
ILE A1276
 None
 0.84A 2qmzA-5i8iA:
undetectable
2qmzB-5i8iA:
undetectable		 2qmzA-5i8iA:
11.80
2qmzB-5i8iA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 GLY A1187
GLY A1188
ILE A1189
VAL A1142
ILE A1140
 None
 0.76A 2r5pA-5i8iA:
undetectable		 2r5pA-5i8iA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 GLY A1187
GLY A1188
ILE A1189
VAL A1142
ILE A1140
 None
 0.76A 2r5pC-5i8iA:
undetectable		 2r5pC-5i8iA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 ALA A1575
THR A1643
VAL A1618
GLY A1619
PRO A1590
 None
 1.19A 2ve3B-5i8iA:
undetectable		 2ve3B-5i8iA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 5 ASP A1103
ARG A1180
TYR A1182
GLU A1124
 None
 1.04A 2x8oA-5i8iA:
undetectable		 2x8oA-5i8iA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 ASP A1342
SER A1099
TYR A1194
TRP A1647
 None
 1.27A 2xz5A-5i8iA:
undetectable
2xz5C-5i8iA:
undetectable		 2xz5A-5i8iA:
8.27
2xz5C-5i8iA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
 0.99A 2y7kA-5i8iA:
2.3		 2y7kA-5i8iA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 THR A1643
ILE A1627
GLY A1616
TYR A1628
PRO A1590
 None
 1.40A 2y7kA-5i8iA:
2.3		 2y7kA-5i8iA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 10 THR A1643
ILE A1627
GLY A1616
TYR A1628
PRO A1590
 None
 1.34A 2y7kB-5i8iA:
2.6		 2y7kB-5i8iA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
 1.02A 2y7kC-5i8iA:
2.3		 2y7kC-5i8iA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 THR A1643
ILE A1627
GLY A1616
TYR A1628
PRO A1590
 None
 1.25A 2y7kC-5i8iA:
2.3		 2y7kC-5i8iA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
 1.10A 2y7kD-5i8iA:
2.8		 2y7kD-5i8iA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 10 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
 1.05A 2y7pA-5i8iA:
3.0		 2y7pA-5i8iA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 9 THR A1643
ILE A1627
GLY A1616
TYR A1628
GLY A1641
 None
 1.14A 2y7wA-5i8iA:
2.8		 2y7wA-5i8iA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 LYS A 858
ASN A 912
ARG A 914
GLU A 918
 None
 0.91A 2ys6A-5i8iA:
28.5		 2ys6A-5i8iA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 PHE A1349
GLY A1635
TRP A1549
ARG A1544
 None
 1.26A 3aruA-5i8iA:
undetectable		 3aruA-5i8iA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 VAL A 538
GLY A 543
THR A 601
ILE A 546
THR A 515
 None
 1.27A 3bexC-5i8iA:
undetectable
3bexD-5i8iA:
undetectable		 3bexC-5i8iA:
8.89
3bexD-5i8iA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 10 THR A 515
VAL A 538
GLY A 543
THR A 601
ILE A 546
 None
 1.27A 3bexC-5i8iA:
undetectable
3bexD-5i8iA:
undetectable		 3bexC-5i8iA:
8.89
3bexD-5i8iA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 10 VAL A 538
GLY A 543
THR A 601
ILE A 546
THR A 515
 None
 1.27A 3bexE-5i8iA:
1.5
3bexF-5i8iA:
undetectable		 3bexE-5i8iA:
8.89
3bexF-5i8iA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 THR A 515
VAL A 538
GLY A 543
THR A 601
ILE A 546
 None
 1.28A 3bexE-5i8iA:
1.5
3bexF-5i8iA:
undetectable		 3bexE-5i8iA:
8.89
3bexF-5i8iA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 VAL A 538
GLY A 543
THR A 601
ILE A 546
THR A 515
 None
 1.28A 3bf1A-5i8iA:
undetectable
3bf1B-5i8iA:
undetectable		 3bf1A-5i8iA:
8.89
3bf1B-5i8iA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 VAL A 538
GLY A 543
THR A 601
ILE A 546
THR A 515
 None
 1.27A 3bf1C-5i8iA:
undetectable
3bf1D-5i8iA:
undetectable		 3bf1C-5i8iA:
8.89
3bf1D-5i8iA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 LEU A 535
THR A 515
VAL A 538
THR A 601
ILE A 546
 None
 1.34A 3bf1C-5i8iA:
undetectable
3bf1D-5i8iA:
undetectable		 3bf1C-5i8iA:
8.89
3bf1D-5i8iA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 THR A 515
VAL A 538
GLY A 543
THR A 601
ILE A 546
 None
 1.29A 3bf1C-5i8iA:
undetectable
3bf1D-5i8iA:
undetectable		 3bf1C-5i8iA:
8.89
3bf1D-5i8iA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 VAL A 538
GLY A 543
THR A 601
ILE A 546
THR A 515
 None
 1.25A 3bf1E-5i8iA:
1.5
3bf1F-5i8iA:
undetectable		 3bf1E-5i8iA:
8.89
3bf1F-5i8iA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 THR A 515
VAL A 538
GLY A 543
THR A 601
ILE A 546
 None
 1.30A 3bf1E-5i8iA:
1.5
3bf1F-5i8iA:
undetectable		 3bf1E-5i8iA:
8.89
3bf1F-5i8iA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 TYR A 148
ASN A 381
PRO A 272
TRP A 265
 None
 1.42A 3bjwD-5i8iA:
undetectable		 3bjwD-5i8iA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 7 VAL A 538
LYS A 520
ILE A 546
GLY A 605
LEU A 493
 None
 1.46A 3bjwH-5i8iA:
undetectable		 3bjwH-5i8iA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 ILE A1010
GLU A 861
ILE A 860
LEU A1027
ILE A1009
 None
 1.07A 3cd2A-5i8iA:
undetectable		 3cd2A-5i8iA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 PHE A1071
THR A1150
VAL A1073
LEU A1214
THR A1080
 None
 1.11A 3elzA-5i8iA:
undetectable		 3elzA-5i8iA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 10 VAL A1375
PHE A1374
LEU A1385
VAL A1381
LEU A1404
 None
 0.92A 3gwxA-5i8iA:
undetectable		 3gwxA-5i8iA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		6 / 12 LEU A  25
GLY A 114
LEU A  69
GLN A  56
LEU A  53
ILE A  48
 None
 1.45A 3ijdA-5i8iA:
undetectable		 3ijdA-5i8iA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 5 LYS A 245
PRO A 247
SER A 249
SER A 552
 None
 1.39A 3ijxH-5i8iA:
undetectable		 3ijxH-5i8iA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 5 LYS A 245
PRO A 247
SER A 249
SER A 552
 None
 1.49A 3iluH-5i8iA:
undetectable		 3iluH-5i8iA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 TRP A   7
PHE A  15
SER A   8
ILE A 165
LEU A  31
 None
 1.09A 3iv6A-5i8iA:
undetectable		 3iv6A-5i8iA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 TRP A   7
PHE A  15
SER A   8
ILE A 165
LEU A  31
 None
 1.01A 3iv6C-5i8iA:
3.2		 3iv6C-5i8iA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 GLU A1447
ARG A1306
ALA A1312
GLU A1311
GLU A1449
 None
 1.50A 3k39A-5i8iA:
undetectable		 3k39A-5i8iA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_M_BCZM1001_0
(NEURAMINIDASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 GLU A1447
ARG A1306
ALA A1312
GLU A1311
GLU A1449
 None
 1.50A 3k39M-5i8iA:
undetectable		 3k39M-5i8iA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 GLY A 156
CYH A 378
PHE A 419
PHE A 144
 None
 1.03A 3ko0D-5i8iA:
undetectable
3ko0E-5i8iA:
undetectable		 3ko0D-5i8iA:
4.13
3ko0E-5i8iA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 GLY A1621
CYH A1351
PHE A1331
PHE A1271
 None
 1.10A 3ko0B-5i8iA:
undetectable
3ko0J-5i8iA:
undetectable		 3ko0B-5i8iA:
4.13
3ko0J-5i8iA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 PHE A 144
GLY A 156
CYH A 378
PHE A 419
 None
 0.96A 3ko0B-5i8iA:
undetectable
3ko0J-5i8iA:
undetectable		 3ko0B-5i8iA:
4.13
3ko0J-5i8iA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 GLY A 178
CYH A 374
PHE A 294
PHE A 404
 None
 1.11A 3ko0L-5i8iA:
undetectable
3ko0N-5i8iA:
undetectable		 3ko0L-5i8iA:
4.13
3ko0N-5i8iA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 GLY A1309
GLY A1622
PHE A1331
PHE A1271
 None
 0.96A 3ko0M-5i8iA:
undetectable
3ko0P-5i8iA:
undetectable		 3ko0M-5i8iA:
4.13
3ko0P-5i8iA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 GLY A1621
CYH A1351
PHE A1331
PHE A1271
 None
 1.11A 3ko0K-5i8iA:
undetectable
3ko0S-5i8iA:
undetectable		 3ko0K-5i8iA:
4.13
3ko0S-5i8iA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 GLY A1621
CYH A1351
PHE A1331
PHE A1271
 None
 1.13A 3ko0R-5i8iA:
undetectable
3ko0T-5i8iA:
undetectable		 3ko0R-5i8iA:
4.13
3ko0T-5i8iA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 PHE A 404
GLY A 178
CYH A 374
PHE A 294
 None
 1.09A 3ko0R-5i8iA:
undetectable
3ko0T-5i8iA:
undetectable		 3ko0R-5i8iA:
4.13
3ko0T-5i8iA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 ARG A1016
THR A1005
ALA A 959
LEU A1023
LEU A 961
 None
 1.30A 3lcvB-5i8iA:
undetectable		 3lcvB-5i8iA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 6 ASN A 406
LEU A 209
ASP A 210
LYS A 207
 None
 1.32A 3lslG-5i8iA:
2.1		 3lslG-5i8iA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 GLY A1144
GLY A1145
PRO A1130
VAL A1073
LEU A1132
 None
 0.94A 3m6wA-5i8iA:
undetectable		 3m6wA-5i8iA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 GLY A1167
VAL A1073
PRO A1130
VAL A1082
LEU A1123
 None
 0.98A 3m6wA-5i8iA:
undetectable		 3m6wA-5i8iA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 ILE A 648
PHE A 624
ILE A 700
ALA A 630
GLY A 726
 None
 1.08A 3nxuA-5i8iA:
undetectable		 3nxuA-5i8iA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 LEU A 187
LEU A 217
ALA A 216
LEU A 168
GLY A 171
 None
 1.00A 3olsA-5i8iA:
undetectable		 3olsA-5i8iA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 PHE A1349
GLY A1621
GLY A1622
ASN A1318
ILE A1557
 None
 1.26A 3owxA-5i8iA:
undetectable
3owxB-5i8iA:
undetectable		 3owxA-5i8iA:
10.91
3owxB-5i8iA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 VAL A1617
GLY A1621
GLY A1622
ASN A1318
ILE A1557
 None
 1.25A 3owxA-5i8iA:
undetectable
3owxB-5i8iA:
undetectable		 3owxA-5i8iA:
10.91
3owxB-5i8iA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 LEU A 187
LEU A 217
ALA A 216
LEU A 168
GLY A 171
 None
 1.00A 3q95B-5i8iA:
undetectable		 3q95B-5i8iA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		3 / 3 HIS A 919
ARG A 638
GLU A 634
 None
 1.19A 3qf1A-5i8iA:
undetectable		 3qf1A-5i8iA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 4 PHE A1349
TYR A1606
ILE A1298
LEU A1297
 None
 1.44A 3sudA-5i8iA:
undetectable		 3sudA-5i8iA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 5 PHE A1349
TYR A1606
ILE A1298
LEU A1297
 None
 1.34A 3sueC-5i8iA:
undetectable		 3sueC-5i8iA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 6 PHE A 561
PHE A 558
PHE A 585
ALA A 487
 None
 1.09A 3t3sB-5i8iA:
undetectable		 3t3sB-5i8iA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 10 THR A1037
LEU A 977
THR A 996
LEU A 961
THR A 990
 None
 1.37A 3tbgC-5i8iA:
3.2		 3tbgC-5i8iA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		3 / 3 ARG A 873
MET A 876
ARG A 877
 None
 1.25A 3uvvA-5i8iA:
undetectable		 3uvvA-5i8iA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 LEU A1222
ALA A1122
LEU A1214
LEU A1132
THR A1138
 None
 1.32A 3vhuA-5i8iA:
undetectable		 3vhuA-5i8iA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 ILE A1508
GLU A1505
TYR A1445
VAL A1323
 None
 1.11A 4a97A-5i8iA:
3.5		 4a97A-5i8iA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 ILE A1508
GLU A1505
TYR A1445
VAL A1323
 None
 1.03A 4a97D-5i8iA:
3.4		 4a97D-5i8iA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 ILE A1508
GLU A1505
TYR A1445
VAL A1323
 None
 1.09A 4a97H-5i8iA:
undetectable		 4a97H-5i8iA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 6 GLY A1588
ILE A1094
LYS A1519
LEU A1663
 None
 1.13A 4ac9C-5i8iA:
2.9		 4ac9C-5i8iA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 6 GLY A1588
ILE A1094
LYS A1519
LEU A1663
 None
 1.14A 4acaC-5i8iA:
undetectable		 4acaC-5i8iA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 LEU A1663
LYS A1519
VAL A1695
LEU A1523
 None
 1.03A 4b3qA-5i8iA:
4.5		 4b3qA-5i8iA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 LEU A 535
ARG A 536
GLY A 604
SER A 544
 None
 1.00A 4cp3A-5i8iA:
undetectable
4cp3B-5i8iA:
undetectable		 4cp3A-5i8iA:
5.64
4cp3B-5i8iA:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 ARG A 313
SER A 177
GLY A 171
VAL A 212
SER A 154
 None
 0.98A 4danA-5i8iA:
undetectable
4danB-5i8iA:
undetectable		 4danA-5i8iA:
8.86
4danB-5i8iA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 ASP A1584
ASP A1321
GLY A1636
SER A1609
ARG A1296
 None
 1.04A 4djfB-5i8iA:
undetectable		 4djfB-5i8iA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 5 LEU A1497
LEU A1501
MET A1476
THR A1470
 None
 1.27A 4do3A-5i8iA:
32.8		 4do3A-5i8iA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 5 THR A1126
GLN A1083
GLU A1124
THR A1080
 None
 1.28A 4eahA-5i8iA:
undetectable
4eahE-5i8iA:
2.1
4eahG-5i8iA:
undetectable		 4eahA-5i8iA:
13.41
4eahE-5i8iA:
13.41
4eahG-5i8iA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 6 GLY A1621
GLY A1622
ASN A1318
ILE A1557
 None
 0.96A 4fglD-5i8iA:
undetectable		 4fglD-5i8iA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 ILE A 428
ILE A 259
LYS A 433
GLY A 432
 None
 0.81A 4hdlA-5i8iA:
undetectable		 4hdlA-5i8iA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 ARG A 638
GLN A 833
GLY A 893
THR A 894
 None
 0.96A 4k87A-5i8iA:
3.3		 4k87A-5i8iA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 ALA A1356
PHE A1374
VAL A1286
LEU A1297
ILE A1329
 None
 1.11A 4km2B-5i8iA:
undetectable		 4km2B-5i8iA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		7 / 7 LYS A 858
ASN A 912
ARG A 914
GLN A 916
VAL A 917
GLU A 918
ARG A 960
 None
 0.63A 4mv7A-5i8iA:
55.7		 4mv7A-5i8iA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 5 ILE A1709
LEU A1706
ASP A1451
VAL A1516
 None
 0.78A 4nkxB-5i8iA:
undetectable		 4nkxB-5i8iA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		3 / 3 ASN A 230
ASP A 437
ASP A 409
 None
 0.76A 4obwD-5i8iA:
undetectable		 4obwD-5i8iA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 GLN A 916
MET A 834
VAL A 895
MET A 934
ILE A 937
 None
 1.09A 4ok1A-5i8iA:
undetectable		 4ok1A-5i8iA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 GLN A 916
MET A 834
VAL A 895
MET A 934
ILE A 937
 None
 1.11A 4oktA-5i8iA:
undetectable		 4oktA-5i8iA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 GLN A 916
MET A 834
VAL A 895
MET A 934
ILE A 937
 None
 1.13A 4okwA-5i8iA:
undetectable		 4okwA-5i8iA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 SER A1609
GLY A1347
GLY A1348
THR A1332
ASP A1321
 None
 1.15A 4pghD-5i8iA:
undetectable		 4pghD-5i8iA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 LEU A 187
LEU A 217
ALA A 216
LEU A 168
GLY A 171
 None
 0.97A 4pxmA-5i8iA:
undetectable		 4pxmA-5i8iA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 ALA A  92
SER A 169
GLY A 156
ALA A 155
 None
 0.85A 4r1zB-5i8iA:
undetectable		 4r1zB-5i8iA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 THR A  89
THR A  90
ALA A  91
ALA A  92
ASN A  81
 None
 1.49A 4u15B-5i8iA:
undetectable		 4u15B-5i8iA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_C_EF2C151_1
(CEREBLON ISOFORM 4)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 ASN A 324
PRO A 325
PHE A 320
TYR A 314
 None
 1.45A 4v2yC-5i8iA:
undetectable		 4v2yC-5i8iA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 ASN A 324
PRO A 325
PHE A 320
TYR A 314
 None
 1.49A 4v2zC-5i8iA:
undetectable		 4v2zC-5i8iA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 LEU A1214
TYR A1209
GLU A1124
LEU A1123
LEU A1220
 None
 1.07A 4wg0K-5i8iA:
undetectable
4wg0L-5i8iA:
undetectable
4wg0M-5i8iA:
undetectable		 4wg0K-5i8iA:
2.71
4wg0L-5i8iA:
2.71
4wg0M-5i8iA:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 5 LEU A 443
ASP A 442
LEU A 430
THR A 285
 None
 1.28A 4wozF-5i8iA:
undetectable
4wozH-5i8iA:
undetectable		 4wozF-5i8iA:
9.90
4wozH-5i8iA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 ASP A  11
TYR A 459
ILE A 188
ASP A 471
 None
 0.98A 4xjeA-5i8iA:
2.8		 4xjeA-5i8iA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 6 LEU A 887
ILE A 744
ALA A 745
ALA A 879
 None
 0.73A 4zf8A-5i8iA:
undetectable		 4zf8A-5i8iA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 10 TYR A1322
LEU A1448
PRO A1264
LEU A1270
GLY A1313
 None
 1.39A 4zp0A-5i8iA:
undetectable		 4zp0A-5i8iA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 VAL A1617
GLY A1621
GLY A1622
ASN A1318
ILE A1557
 None
 1.28A 4zvmA-5i8iA:
undetectable
4zvmB-5i8iA:
3.6		 4zvmA-5i8iA:
11.80
4zvmB-5i8iA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 ASP A 210
GLY A 171
THR A 174
LYS A  79
 None
 1.12A 4zxiA-5i8iA:
5.3		 4zxiA-5i8iA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		3 / 3 ARG A1292
TYR A1182
GLU A1124
 None
 0.68A 4zzbE-5i8iA:
undetectable		 4zzbE-5i8iA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 ASN A 324
PRO A 325
PHE A 320
TYR A 314
 None
 1.37A 5amhA-5i8iA:
undetectable		 5amhA-5i8iA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 VAL A 538
GLY A 543
THR A 601
ILE A 546
THR A 515
 None
 1.26A 5b8hA-5i8iA:
2.1
5b8hB-5i8iA:
undetectable		 5b8hA-5i8iA:
9.76
5b8hB-5i8iA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 VAL A 538
THR A 601
ILE A 546
LEU A 535
THR A 515
 None
 1.29A 5b8hA-5i8iA:
2.1
5b8hB-5i8iA:
undetectable		 5b8hA-5i8iA:
9.76
5b8hB-5i8iA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 LEU A 535
THR A 515
VAL A 538
THR A 601
ILE A 546
 None
 1.28A 5b8hA-5i8iA:
2.1
5b8hB-5i8iA:
undetectable		 5b8hA-5i8iA:
9.76
5b8hB-5i8iA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 ASP A  11
TYR A 459
ILE A 188
ASP A 471
 None
 0.93A 5cfsA-5i8iA:
2.4		 5cfsA-5i8iA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 5 GLY A 176
PRO A 379
THR A 402
GLN A 398
 None
 0.96A 5h5fA-5i8iA:
2.3		 5h5fA-5i8iA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 6 VAL A 372
LEU A 255
CYH A 374
LEU A 282
 None
 0.96A 5hrqB-5i8iA:
undetectable
5hrqI-5i8iA:
undetectable
5hrqJ-5i8iA:
undetectable		 5hrqB-5i8iA:
2.21
5hrqI-5i8iA:
1.21
5hrqJ-5i8iA:
2.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 11 SER A 177
GLY A 171
VAL A 212
SER A 154
ILE A  82
 None
 1.13A 5i3cC-5i8iA:
undetectable		 5i3cC-5i8iA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 5 GLU A 881
GLY A 836
SER A 885
GLY A 840
 None
 1.07A 5kprA-5i8iA:
undetectable		 5kprA-5i8iA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 9 LEU A 304
ASN A 403
GLY A 399
VAL A 405
GLY A 178
 None
 1.00A 5kr0B-5i8iA:
undetectable		 5kr0B-5i8iA:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 9 SER A 213
GLY A 178
ALA A 158
LEU A 187
GLY A 189
 None
 1.44A 5l8rA-5i8iA:
undetectable		 5l8rA-5i8iA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 LEU A 977
ALA A1007
PHE A 982
PRO A1192
 None
 0.98A 5m0oC-5i8iA:
undetectable		 5m0oC-5i8iA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 7 GLY A1603
ALA A1728
ASP A1559
PHE A1556
ASN A1318
 None
 1.42A 5mvsA-5i8iA:
undetectable		 5mvsA-5i8iA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 GLY A 460
ALA A 182
PHE A 144
PHE A 419
 None
 0.90A 5mvsB-5i8iA:
undetectable		 5mvsB-5i8iA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 4 ASN A 185
SER A 154
ALA A 158
VAL A 161
 None
 1.36A 5nm5A-5i8iA:
undetectable		 5nm5A-5i8iA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		3 / 3 GLY A 138
THR A 140
ASN A 122
 None
 0.58A 5odiG-5i8iA:
4.0		 5odiG-5i8iA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 ASN A 324
PRO A 325
PHE A 320
TYR A 314
 None
 1.47A 5oh3A-5i8iA:
undetectable		 5oh3A-5i8iA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 ALA A 278
PHE A 448
PHE A 447
LEU A 441
LEU A 219
 None
 0.81A 5tudA-5i8iA:
2.1		 5tudA-5i8iA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 GLU A 262
VAL A 375
CYH A 374
ASP A 293
PHE A 294
 None
 1.26A 5vlmC-5i8iA:
undetectable		 5vlmC-5i8iA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 8 GLN A 833
GLY A 846
GLU A 881
ILE A 950
 None
 1.04A 5vlmD-5i8iA:
undetectable		 5vlmD-5i8iA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 6 PRO A1121
GLY A1188
ARG A1198
VAL A1082
 None
 0.96A 5x80A-5i8iA:
undetectable
5x80B-5i8iA:
undetectable		 5x80A-5i8iA:
7.09
5x80B-5i8iA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 ARG A1198
VAL A1082
PRO A1121
GLY A1188
 None
 0.98A 5x80C-5i8iA:
undetectable
5x80D-5i8iA:
2.1		 5x80C-5i8iA:
7.09
5x80D-5i8iA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 6 GLY A 129
SER A 135
THR A 133
VAL A 131
 None
 1.22A 5ysiA-5i8iA:
undetectable		 5ysiA-5i8iA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 7 ARG A 200
ARG A 102
THR A 101
PRO A 100
 None
 1.24A 6a4iB-5i8iA:
undetectable		 6a4iB-5i8iA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA607_0
(ALPHA-AMYLASE)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		4 / 4 ARG A 420
SER A 421
ASP A 422
ASN A 271
 None
 0.92A 6ag0A-5i8iA:
undetectable		 6ag0A-5i8iA:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 ALA A 183
ASN A 381
GLY A 427
SER A 417
GLY A 418
 None
 1.11A 6c79A-5i8iA:
undetectable		 6c79A-5i8iA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 5i8i UREA AMIDOLYASE
(Kluyveromyces
lactis) 		5 / 12 ASN A1561
GLY A1621
ILE A1557
GLU A1311
LEU A1602
 None
 1.06A 6ectA-5i8iA:
undetectable		 6ectA-5i8iA:
10.33