SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 5i8k HHH1 FAB LIGHT CHAIN
(Homo
sapiens) 		5 / 12 ASN L  32
ILE L  50
PHE L  73
GLY L  66
THR L  76
 None
 1.44A 1g60B-5i8kL:
undetectable		 1g60B-5i8kL:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5i8k HHH1 FAB HEAVY CHAIN
HHH1 FAB LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 TRP H 100
VAL L  29
TRP L  30
 None
 1.38A 1gmkC-5i8kH:
undetectable
1gmkD-5i8kH:
undetectable		 1gmkC-5i8kH:
5.62
1gmkD-5i8kH:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 5i8k HHH1 FAB LIGHT CHAIN
(Homo
sapiens) 		4 / 7 LEU L 138
THR L 175
SER L 165
THR L 167
 None
 0.73A 1ictD-5i8kL:
undetectable		 1ictD-5i8kL:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5i8k HHH1 FAB LIGHT CHAIN
(Homo
sapiens) 		4 / 5 LEU L 182
GLY L 131
PRO L 123
VAL L 135
 None
 0.81A 2aojA-5i8kL:
undetectable		 2aojA-5i8kL:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 5i8k HHH1 FAB HEAVY CHAIN
HHH1 FAB LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 5 TRP H  47
GLY L 102
LEU L  94
PRO H  98
 None
 1.50A 2dqyA-5i8kH:
undetectable		 2dqyA-5i8kH:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 6 GLU H   2
TYR H  32
HIS H  33
VAL H  76
PHE H  27
 None
 1.34A 4a97E-5i8kH:
undetectable		 4a97E-5i8kH:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 8 SER H 131
LEU H 127
ALA H 140
SER H 130
 None
 0.94A 4iklA-5i8kH:
3.2
4iklB-5i8kH:
undetectable		 4iklA-5i8kH:
19.53
4iklB-5i8kH:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 191
GLY H 137
THR H 138
ALA H 139
THR H 134
 None
 0.88A 4qvpH-5i8kH:
undetectable
4qvpI-5i8kH:
undetectable		 4qvpH-5i8kH:
19.28
4qvpI-5i8kH:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 191
GLY H 137
THR H 138
ALA H 139
THR H 134
 None
 0.88A 4qvpV-5i8kH:
undetectable
4qvpW-5i8kH:
undetectable		 4qvpV-5i8kH:
19.28
4qvpW-5i8kH:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 191
GLY H 137
THR H 138
ALA H 139
THR H 134
 None
 0.93A 4qvvH-5i8kH:
undetectable		 4qvvH-5i8kH:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 191
GLY H 137
THR H 138
ALA H 139
THR H 134
 None
 0.93A 4qvvV-5i8kH:
undetectable		 4qvvV-5i8kH:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 191
GLY H 137
THR H 138
ALA H 139
THR H 134
 None
 0.91A 4qvyH-5i8kH:
undetectable		 4qvyH-5i8kH:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 191
GLY H 137
THR H 138
ALA H 139
THR H 134
 None
 0.91A 4qvyV-5i8kH:
undetectable
4qvyW-5i8kH:
undetectable		 4qvyV-5i8kH:
19.28
4qvyW-5i8kH:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 191
GLY H 137
THR H 138
ALA H 139
THR H 134
 None
 0.91A 4qw0H-5i8kH:
undetectable
4qw0I-5i8kH:
undetectable		 4qw0H-5i8kH:
19.28
4qw0I-5i8kH:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 191
GLY H 137
THR H 138
ALA H 139
THR H 134
 None
 0.91A 4qw0V-5i8kH:
undetectable
4qw0W-5i8kH:
undetectable		 4qw0V-5i8kH:
19.28
4qw0W-5i8kH:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5i8k HHH1 FAB HEAVY CHAIN
HHH1 FAB LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE L  50
GLN L   6
TYR L  88
GLN H  39
LEU H  45
 None
 1.40A 4qztA-5i8kL:
undetectable		 4qztA-5i8kL:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5i8k HHH1 FAB LIGHT CHAIN
(Homo
sapiens) 		4 / 5 VAL L  19
ILE L  21
VAL L 107
THR L 105
 None
 0.71A 4xdtA-5i8kL:
undetectable		 4xdtA-5i8kL:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 191
GLY H 137
THR H 138
ALA H 139
THR H 134
 None
 0.91A 5bxnH-5i8kH:
undetectable
5bxnI-5i8kH:
undetectable		 5bxnH-5i8kH:
20.39
5bxnI-5i8kH:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 191
GLY H 137
THR H 138
ALA H 139
THR H 134
 None
 0.91A 5cz7V-5i8kH:
undetectable
5cz7W-5i8kH:
undetectable		 5cz7V-5i8kH:
19.28
5cz7W-5i8kH:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 191
GLY H 137
THR H 138
ALA H 139
THR H 134
 None
 0.91A 5d0xV-5i8kH:
undetectable		 5d0xV-5i8kH:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 191
GLY H 137
THR H 138
ALA H 139
THR H 134
 None
 0.87A 5l5fH-5i8kH:
undetectable
5l5fI-5i8kH:
undetectable		 5l5fH-5i8kH:
19.28
5l5fI-5i8kH:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 191
GLY H 137
THR H 138
ALA H 139
THR H 134
 None
 0.87A 5l5fV-5i8kH:
undetectable
5l5fW-5i8kH:
undetectable		 5l5fV-5i8kH:
19.28
5l5fW-5i8kH:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 5i8k HHH1 FAB HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER H 115
ALA H 117
PHE H 149
LEU H 173
 None
 0.41A 5mthA-5i8kH:
26.1		 5mthA-5i8kH:
52.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5i8k HHH1 FAB LIGHT CHAIN
(Homo
sapiens) 		5 / 11 VAL L  11
SER L  10
THR L 105
VAL L  15
LEU L  80
 None
 1.21A 6dryA-5i8kL:
undetectable		 6dryA-5i8kL:
20.54