SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 5i8o HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 ASN L  32
ILE L  50
PHE L  73
GLY L  66
THR L  76
 None
 1.48A 1g60B-5i8oL:
undetectable		 1g60B-5i8oL:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 5i8o HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 LEU L 138
THR L 175
SER L 165
THR L 167
 None
 0.77A 1ictD-5i8oL:
undetectable		 1ictD-5i8oL:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 LEU L  91
TYR L  93
TRP H  46
TYR L  38
 None
 0.95A 1lweA-5i8oL:
undetectable		 1lweA-5i8oL:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5i8o HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 ASN L  99
ILE L  98
GLY L  96
GLY L  31
 None
 0.71A 1me7A-5i8oL:
undetectable		 1me7A-5i8oL:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5i8o HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens) 		4 / 5 LEU L 182
GLY L 131
PRO L 123
VAL L 135
 None
 0.81A 2aojA-5i8oL:
undetectable		 2aojA-5i8oL:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
(Homo
sapiens) 		4 / 6 ILE H 198
ARG H 212
PRO H 122
SER H 206
 None
 1.35A 2qd3B-5i8oH:
undetectable		 2qd3B-5i8oH:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 ARG H  37
SER H 100
TYR L  38
VAL H  36
 None
 1.34A 2y05A-5i8oH:
undetectable
2y05B-5i8oH:
undetectable		 2y05A-5i8oH:
21.00
2y05B-5i8oH:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL L 100
GLY H  48
TYR L  94
ILE H  33
ASN H  32
 None
None
None
None
FUC  H 301 (-3.2A)
 1.38A 3bwmA-5i8oL:
undetectable		 3bwmA-5i8oL:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL L 100
GLY H  48
TYR L  94
ILE H  50
ASN H  32
 None
None
None
None
FUC  H 301 (-3.2A)
 1.37A 3bwmA-5i8oL:
undetectable		 3bwmA-5i8oL:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 THR H  88
GLU H 151
HIS H 203
 None
 0.80A 3g1uB-5i8oH:
undetectable		 3g1uB-5i8oH:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
(Homo
sapiens) 		4 / 4 SER H 189
SER H 131
THR H 134
SER H 133
 None
 1.44A 3loqA-5i8oH:
undetectable		 3loqA-5i8oH:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 LEU H 111
GLN H  38
THR H  90
GLU H 151
 None
 1.14A 3n58C-5i8oH:
undetectable		 3n58C-5i8oH:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 ASP H  98
SER H 102
THR H 103
ASN H 104
TYR L  34
 2F8  H 302 (-4.2A)
None
None
None
None
 1.07A 3rzeA-5i8oH:
undetectable		 3rzeA-5i8oH:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5i8o HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens) 		5 / 12 GLY L 131
LEU L 184
SER L 134
ASP L 188
ALA L 187
 None
 1.06A 4krhA-5i8oL:
undetectable		 4krhA-5i8oL:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5i8o HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens) 		4 / 5 VAL L  19
ILE L  21
VAL L 107
THR L 105
 None
 0.70A 4xdtA-5i8oL:
undetectable		 4xdtA-5i8oL:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL L 100
GLY H  48
TYR L  94
ILE H  33
ASN H  32
 None
None
None
None
FUC  H 301 (-3.2A)
 1.42A 4xueB-5i8oL:
undetectable		 4xueB-5i8oL:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL L 100
GLY H  48
TYR L  94
ILE H  50
ASN H  32
 None
None
None
None
FUC  H 301 (-3.2A)
 1.37A 4xueB-5i8oL:
undetectable		 4xueB-5i8oL:
25.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5i8o HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens) 		4 / 8 TYR L  94
GLY L  92
ILE L  21
GLY L 102
 None
 0.83A 5alcL-5i8oL:
21.4		 5alcL-5i8oL:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 THR L  71
GLY L  92
ALA H 101
ALA L  36
TYR L  38
 None
 1.20A 5kvaA-5i8oL:
undetectable		 5kvaA-5i8oL:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 THR L  71
GLY L  92
ALA H 101
ALA L  36
TYR L  38
 None
 1.18A 5kvaB-5i8oL:
undetectable		 5kvaB-5i8oL:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 5i8o HMM5 ANTIBODY HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 SER H 115
ALA H 117
PHE H 149
LEU H 173
 None
 0.39A 5mthA-5i8oH:
25.9		 5mthA-5i8oH:
50.89