SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i92'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 11 ASN A 182
ALA A 216
LEU A 220
THR A 241
ALA A 250
 None
 1.20A 1rv7A-5i92A:
undetectable
1rv7B-5i92A:
undetectable		 1rv7A-5i92A:
13.22
1rv7B-5i92A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 244
GLY A 352
ALA A 351
HIS A 321
 None
 0.98A 1wmqA-5i92A:
undetectable		 1wmqA-5i92A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 244
GLY A 352
ALA A 351
HIS A 321
 None
 0.99A 1wmqB-5i92A:
undetectable		 1wmqB-5i92A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 244
GLY A 352
ALA A 351
HIS A 321
 None
 0.99A 1wpuA-5i92A:
undetectable		 1wpuA-5i92A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 244
GLY A 352
ALA A 351
HIS A 321
 None
 0.98A 1wpuB-5i92A:
undetectable		 1wpuB-5i92A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 244
GLY A 352
ALA A 351
HIS A 321
 None
 1.01A 1wrqA-5i92A:
undetectable		 1wrqA-5i92A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 244
GLY A 352
ALA A 351
HIS A 321
 None
 0.99A 1wrqB-5i92A:
undetectable		 1wrqB-5i92A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 327
MET A 331
THR A 329
LEU A 332
 None
 1.35A 2eimJ-5i92A:
undetectable		 2eimJ-5i92A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 140
PHE A 368
PRO A 180
THR A 178
 None
 1.27A 2m2oB-5i92A:
undetectable		 2m2oB-5i92A:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 181
LEU A 220
ILE A 201
GLY A 218
 None
 1.00A 2v0mC-5i92A:
undetectable		 2v0mC-5i92A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 8 GLN A  12
GLY A  17
PRO A  33
GLY A  30
 None
 0.94A 2y6rB-5i92A:
undetectable		 2y6rB-5i92A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 244
PRO A  61
GLY A  60
TRP A  59
 None
 1.28A 2y7kB-5i92A:
undetectable		 2y7kB-5i92A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 12 PRO A 272
GLY A 308
THR A 311
LEU A 303
VAL A  75
 None
 1.18A 2zifB-5i92A:
undetectable		 2zifB-5i92A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 122
VAL A 233
ILE A 282
PRO A 258
ILE A 235
 None
 0.98A 3em3B-5i92A:
undetectable		 3em3B-5i92A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 267
GLY A 268
GLY A 269
ALA A 306
VAL A 273
 None
 0.94A 3jb2A-5i92A:
undetectable		 3jb2A-5i92A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 234
VAL A 203
LEU A 191
ILE A 136
ALA A 226
 None
 1.09A 3mdvA-5i92A:
undetectable		 3mdvA-5i92A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 122
VAL A 233
ILE A 282
GLY A 278
ILE A 235
 None
 1.10A 3mwsB-5i92A:
undetectable		 3mwsB-5i92A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 122
VAL A 233
ILE A 282
PRO A 258
ILE A 235
 None
 1.05A 3oxvB-5i92A:
undetectable		 3oxvB-5i92A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 122
VAL A 233
ILE A 282
PRO A 258
ILE A 235
 None
 1.02A 3oxvD-5i92A:
undetectable		 3oxvD-5i92A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_2
(HIV-1 PROTEASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 122
VAL A 233
ILE A 282
PRO A 258
ILE A 235
 None
 0.98A 3oxwB-5i92A:
undetectable		 3oxwB-5i92A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 232
ALA A 126
ILE A 123
ILE A 201
THR A 130
 None
 1.18A 3qfxA-5i92A:
undetectable		 3qfxA-5i92A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 232
ALA A 126
ILE A 123
ILE A 201
THR A 130
 None
 1.17A 3qfxB-5i92A:
undetectable		 3qfxB-5i92A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 353
LEU A 324
PHE A 355
ASP A  54
PHE A 320
 None
None
EDO  A 502 ( 4.6A)
None
None
 1.31A 3tbgC-5i92A:
2.0		 3tbgC-5i92A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 5 HIS A  66
GLY A  57
TYR A  43
GLU A 411
 None
 1.39A 4ae1B-5i92A:
undetectable		 4ae1B-5i92A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 7 ALA A 419
PHE A 382
ALA A 339
LEU A 335
 None
 0.93A 4du2A-5i92A:
undetectable		 4du2A-5i92A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 6 PHE A 346
PHE A 359
ALA A 419
THR A 415
LEU A 393
 None
None
None
None
EDO  A 502 ( 3.8A)
 1.49A 4ejgD-5i92A:
undetectable		 4ejgD-5i92A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 270
ILE A 267
LEU A 312
LEU A 309
 None
 0.84A 4mwzB-5i92A:
undetectable		 4mwzB-5i92A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 183
PRO A 217
THR A 367
ASP A 370
 None
 1.06A 4pcuA-5i92A:
undetectable		 4pcuA-5i92A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 266
LEU A 247
ALA A 246
PHE A 243
ILE A 267
 None
 0.85A 4pssA-5i92A:
undetectable		 4pssA-5i92A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 4 TYR A  55
THR A 403
GLY A 401
LEU A 357
 None
None
EDO  A 502 (-3.7A)
EDO  A 502 (-3.8A)
 1.18A 4w5nA-5i92A:
2.5		 4w5nA-5i92A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 5 HIS A  68
VAL A  75
GLY A 308
ALA A 306
 None
 1.06A 5hwaA-5i92A:
undetectable		 5hwaA-5i92A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 246
VAL A 245
GLU A 238
TYR A 253
ALA A 275
 None
 1.08A 5n5dA-5i92A:
3.1		 5n5dA-5i92A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		6 / 12 LEU A 247
ALA A 246
VAL A 245
GLU A 238
TYR A 253
ALA A 275
 None
 1.17A 5n5dB-5i92A:
undetectable		 5n5dB-5i92A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 269
VAL A  71
PHE A 243
MET A 102
LEU A  98
 None
 1.49A 5uc3B-5i92A:
undetectable		 5uc3B-5i92A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 5 TYR A 327
MET A 331
THR A 329
LEU A 332
 None
 1.38A 5wauJ-5i92A:
undetectable		 5wauJ-5i92A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 245
TYR A 253
GLU A 238
 None
 0.95A 5zmqD-5i92A:
undetectable
5zmqE-5i92A:
undetectable		 5zmqD-5i92A:
18.14
5zmqE-5i92A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		4 / 5 PHE A 138
VAL A 371
PRO A 215
VAL A 203
 None
 1.24A 6ekzA-5i92A:
undetectable		 6ekzA-5i92A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		5 / 10 TYR A 327
TYR A  55
ASP A 333
THR A 329
THR A 415
 None
 1.47A 6mb9B-5i92A:
undetectable		 6mb9B-5i92A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Pseudomonas
aeruginosa) 		3 / 3 THR A 349
GLU A 204
ASN A 211
 None
None
EDO  A 502 (-2.4A)
 0.80A 6nj9K-5i92A:
2.5		 6nj9K-5i92A:
23.72