SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5i93'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 5 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 NI  A 201 (-3.3A)
NI  A 201 (-2.5A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 1.06A 1os2A-5i93A:
undetectable		 1os2A-5i93A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 NI  A 201 (-3.3A)
NI  A 201 (-2.5A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 1.07A 1os2D-5i93A:
undetectable		 1os2D-5i93A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 NI  A 201 (-3.3A)
NI  A 201 (-2.5A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 1.09A 1utzA-5i93A:
undetectable		 1utzA-5i93A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 NI  A 201 (-3.3A)
NI  A 201 (-2.5A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 1.08A 2hu6A-5i93A:
undetectable		 2hu6A-5i93A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 NI  A 201 (-3.3A)
NI  A 201 (-2.5A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 1.09A 2ow9B-5i93A:
undetectable		 2ow9B-5i93A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 NI  A 201 (-3.3A)
NI  A 201 (-2.5A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 1.07A 2ozrC-5i93A:
undetectable		 2ozrC-5i93A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 NI  A 201 (-3.3A)
NI  A 201 (-2.5A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 1.05A 2ozrD-5i93A:
undetectable		 2ozrD-5i93A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 5 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 NI  A 201 (-3.3A)
NI  A 201 (-2.5A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 1.10A 3likA-5i93A:
undetectable		 3likA-5i93A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 5 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 NI  A 201 (-3.3A)
NI  A 201 (-2.5A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 1.07A 3lkaA-5i93A:
undetectable		 3lkaA-5i93A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 6 THR A  33
GLY A  35
ILE A 131
LEU A  31
 None
 1.11A 4ac9C-5i93A:
undetectable		 4ac9C-5i93A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 6 THR A  33
GLY A  35
ILE A 131
LEU A  31
 None
 1.07A 4acaC-5i93A:
undetectable		 4acaC-5i93A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 6 THR A  33
GLY A  35
ILE A 131
LEU A  31
 None
 1.07A 4acbC-5i93A:
undetectable		 4acbC-5i93A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 4 HIS A 133
GLU A  94
HIS A  90
HIS A  88
 NI  A 201 (-3.3A)
NI  A 201 (-2.5A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 1.10A 5n5jA-5i93A:
undetectable		 5n5jA-5i93A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 8 GLU A  93
PHE A 135
PHE A  84
LEU A 137
 None
69O  A 202 (-3.1A)
69O  A 202 (-3.6A)
None
 1.11A 5y2tB-5i93A:
undetectable		 5y2tB-5i93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		3 / 3 HIS A  88
HIS A 133
HIS A  90
 NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 0.51A 5zrdA-5i93A:
undetectable		 5zrdA-5i93A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Mus
musculus) 		4 / 5 TYR A 104
ASN A 141
ARG A  15
PHE A 135
 None
None
None
69O  A 202 (-3.1A)
 1.39A 6h3dA-5i93A:
undetectable		 6h3dA-5i93A:
16.63