SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iaa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		3 / 3 ASP A 106
PHE A 118
VAL A  81
 None
 0.70A 1kijB-5iaaA:
undetectable		 1kijB-5iaaA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
UBIQUITIN-FOLD
MODIFIER 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ILE C  55
GLY C  56
ALA A 230
HIS C  70
 None
 0.96A 1wmqA-5iaaC:
undetectable		 1wmqA-5iaaC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
UBIQUITIN-FOLD
MODIFIER 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ILE C  55
GLY C  56
ALA A 230
HIS C  70
 None
 0.96A 1wmqB-5iaaC:
undetectable		 1wmqB-5iaaC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
UBIQUITIN-FOLD
MODIFIER 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ILE C  55
GLY C  56
ALA A 230
HIS C  70
 None
 0.95A 1wpuA-5iaaC:
undetectable		 1wpuA-5iaaC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
UBIQUITIN-FOLD
MODIFIER 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ILE C  55
GLY C  56
ALA A 230
HIS C  70
 None
 0.94A 1wpuB-5iaaC:
undetectable		 1wpuB-5iaaC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
UBIQUITIN-FOLD
MODIFIER 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ILE C  55
GLY C  56
ALA A 230
HIS C  70
 None
 0.96A 1wrqA-5iaaC:
undetectable		 1wrqA-5iaaC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
UBIQUITIN-FOLD
MODIFIER 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ILE C  55
GLY C  56
ALA A 230
HIS C  70
 None
 0.96A 1wrqB-5iaaC:
undetectable		 1wrqB-5iaaC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5iaa UBIQUITIN-FOLD
MODIFIER 1
(Homo
sapiens) 		5 / 9 LEU C  21
LEU C  33
PHE C   6
LEU C  74
ILE C   8
 None
 1.14A 2f7aA-5iaaC:
undetectable		 2f7aA-5iaaC:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		4 / 7 GLY A  83
GLY A  82
VAL A 207
LEU A 254
 None
 0.79A 2oa1B-5iaaA:
6.6		 2oa1B-5iaaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 10 LEU A 135
LEU A 102
VAL A  81
PHE A 118
THR A  88
 None
 1.09A 2w9gA-5iaaA:
undetectable		 2w9gA-5iaaA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5iaa UBIQUITIN-FOLD
MODIFIER 1
UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		4 / 8 GLN A 217
MET A 297
ASP C  80
SER A 213
 None
 1.12A 2xytE-5iaaA:
undetectable		 2xytE-5iaaA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5iaa UBIQUITIN-FOLD
MODIFIER 1
UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 12 GLY A 214
SER C  12
THR C  11
ASP C  80
SER C  47
 None
 1.17A 3d91A-5iaaA:
undetectable		 3d91A-5iaaA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 12 LEU A 102
VAL A  84
GLY A  85
PHE A 103
THR A  88
 None
 1.01A 3dh0A-5iaaA:
5.3		 3dh0A-5iaaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 12 LEU A 116
GLY A  85
GLY A  83
ALA A  89
THR A  88
 None
 1.02A 3dh0B-5iaaA:
5.3		 3dh0B-5iaaA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 10 LEU A 135
LEU A 102
VAL A  81
PHE A 118
THR A  88
 None
 1.08A 3fl9E-5iaaA:
undetectable		 3fl9E-5iaaA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 11 LEU A 135
LEU A 102
VAL A  81
PHE A 118
THR A  88
 None
 1.11A 3frbX-5iaaA:
undetectable		 3frbX-5iaaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 9 LEU A 135
LEU A 102
VAL A  81
PHE A 118
THR A  88
 None
 1.11A 3freX-5iaaA:
undetectable		 3freX-5iaaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 12 VAL A 269
LEU A 101
LEU A 179
GLY A  98
LEU A  92
 None
 1.06A 3n8zA-5iaaA:
undetectable		 3n8zA-5iaaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 10 PHE A 103
ILE A 164
SER A 165
LEU A 101
HIS A 147
 None
 1.18A 3o1xA-5iaaA:
undetectable		 3o1xA-5iaaA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 12 VAL A 269
LEU A 101
LEU A 179
GLY A  98
LEU A  92
 None
 1.03A 3pghA-5iaaA:
undetectable		 3pghA-5iaaA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 12 SER A 205
GLY A  83
GLY A 259
ALA A 262
GLY A  85
 None
 1.14A 3tegA-5iaaA:
undetectable		 3tegA-5iaaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		3 / 3 GLU A  90
ARG A  94
GLN A 119
 None
 0.77A 4rtbA-5iaaA:
undetectable		 4rtbA-5iaaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 5iaa UBIQUITIN-FOLD
MODIFIER 1
UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		4 / 8 SER C  12
LEU C  10
ASP C  13
GLN A 289
 None
 0.95A 4umjA-5iaaC:
undetectable		 4umjA-5iaaC:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 5iaa UBIQUITIN-FOLD
MODIFIER 1
(Homo
sapiens) 		4 / 7 ILE C  57
HIS C  70
LEU C  74
GLY C  54
 None
 1.04A 4z69A-5iaaC:
undetectable		 4z69A-5iaaC:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 12 GLY A  80
GLY A  82
THR A  88
ASP A 104
ILE A 151
 None
 1.08A 5bw4A-5iaaA:
4.7		 5bw4A-5iaaA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5iaa UBIQUITIN-FOLD
MODIFIER 1
UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		4 / 6 GLU A 132
GLY C  83
ASP A 183
GLY A  83
 None
 0.88A 5cdnR-5iaaA:
undetectable
5cdnS-5iaaA:
3.7		 5cdnR-5iaaA:
21.38
5cdnS-5iaaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5iaa UBIQUITIN-FOLD
MODIFIER 1
UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		4 / 6 GLU A 132
GLY C  83
ASP A 183
GLY A  83
 None
 0.86A 5cdnC-5iaaA:
undetectable
5cdnD-5iaaA:
3.7		 5cdnC-5iaaA:
21.38
5cdnD-5iaaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5iaa UBIQUITIN-FOLD
MODIFIER 1
UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		4 / 6 GLU A 132
GLY C  83
ASP A 183
GLY A  83
 None
 0.87A 5cdnT-5iaaA:
undetectable
5cdnU-5iaaA:
4.0		 5cdnT-5iaaA:
21.38
5cdnU-5iaaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		4 / 7 ILE A 216
VAL A  76
LEU A 179
LEU A 273
 None
 0.63A 6g9bA-5iaaA:
undetectable
6g9bB-5iaaA:
undetectable		 6g9bA-5iaaA:
14.34
6g9bB-5iaaA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 11 LEU A 273
VAL A 269
ILE A  78
ALA A  77
LEU A  92
 None
 0.99A 6h1lB-5iaaA:
undetectable		 6h1lB-5iaaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 12 VAL A 175
VAL A 178
PHE A 103
PHE A 160
VAL A 146
 None
 1.33A 6iblA-5iaaA:
undetectable		 6iblA-5iaaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens) 		5 / 12 VAL A 175
VAL A 178
PHE A 103
PHE A 160
VAL A 146
 None
 1.31A 6iblB-5iaaA:
undetectable		 6iblB-5iaaA:
21.36