SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		3 / 3 ALA A 105
VAL A 101
TRP A 102
 None
 0.84A 1bdwA-5iaiA:
undetectable
1bdwB-5iaiA:
undetectable		 1bdwA-5iaiA:
4.04
1bdwB-5iaiA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 6 PHE A 356
HIS A 345
ALA A 353
GLY A 352
 None
 0.92A 1c8lA-5iaiA:
undetectable		 1c8lA-5iaiA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 6 PHE A 356
HIS A 345
ALA A 353
GLY A 352
 None
 0.96A 1gfzA-5iaiA:
undetectable		 1gfzA-5iaiA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 11 TRP A 316
VAL A  96
TYR A 106
GLY A 140
LEU A 139
 RB0  A 501 (-3.9A)
None
None
None
None
 1.22A 1i9jH-5iaiA:
undetectable
1i9jL-5iaiA:
undetectable		 1i9jH-5iaiA:
22.33
1i9jL-5iaiA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 6 PHE A 356
HIS A 345
ALA A 353
GLY A 352
 None
 0.88A 1l5qA-5iaiA:
undetectable		 1l5qA-5iaiA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 6 PHE A 356
HIS A 345
ALA A 353
GLY A 352
 None
 0.87A 1l5qB-5iaiA:
undetectable		 1l5qB-5iaiA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 6 PHE A 356
HIS A 345
ALA A 353
GLY A 352
 None
 0.89A 1l7xA-5iaiA:
undetectable		 1l7xA-5iaiA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 6 PHE A 356
HIS A 345
ALA A 353
GLY A 352
 None
 0.88A 1l7xB-5iaiA:
undetectable		 1l7xB-5iaiA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 8 ASP A 209
ILE A 255
GLY A 253
GLY A 260
 None
 0.73A 1me7A-5iaiA:
undetectable		 1me7A-5iaiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 7 ILE A 131
LEU A 139
GLY A 140
PHE A 149
 None
 0.87A 1rtsB-5iaiA:
undetectable		 1rtsB-5iaiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOT_A_2PMA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 10 PHE A  49
GLN A 208
TYR A 154
VAL A 101
TRP A 102
 None
RB0  A 501 (-3.1A)
None
None
None
 1.40A 2aotA-5iaiA:
1.6		 2aotA-5iaiA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 7 ILE A 131
LEU A 139
GLY A 140
PHE A 149
 None
 0.85A 2tsrA-5iaiA:
undetectable		 2tsrA-5iaiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 11 PRO A 173
VAL A 176
GLN A 216
GLY A 219
GLU A 234
 None
 1.48A 3bf6H-5iaiA:
undetectable		 3bf6H-5iaiA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 6 PHE A 356
HIS A 345
ALA A 353
GLY A 352
 None
 0.87A 3dd1A-5iaiA:
undetectable		 3dd1A-5iaiA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 6 PHE A 356
HIS A 345
ALA A 353
GLY A 352
 None
 0.93A 3dd1B-5iaiA:
undetectable		 3dd1B-5iaiA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 6 PHE A 356
HIS A 345
ALA A 353
GLY A 352
 None
 0.90A 3ddsA-5iaiA:
undetectable		 3ddsA-5iaiA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 6 PHE A 356
HIS A 345
ALA A 353
GLY A 352
 None
 0.90A 3ddsB-5iaiA:
undetectable		 3ddsB-5iaiA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 6 PHE A 356
HIS A 345
ALA A 353
GLY A 352
 None
 0.88A 3ddwA-5iaiA:
undetectable		 3ddwA-5iaiA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 6 PHE A 356
HIS A 345
ALA A 353
GLY A 352
 None
 0.89A 3ddwB-5iaiA:
undetectable		 3ddwB-5iaiA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 11 VAL A 279
THR A 276
ASN A 199
GLN A 399
ARG A 262
 None
 1.44A 3kp5A-5iaiA:
undetectable		 3kp5A-5iaiA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 ARG A 262
GLY A 261
ASN A  46
ASN A 199
TYR A  75
 None
 1.41A 3mekA-5iaiA:
undetectable		 3mekA-5iaiA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_C_CU9C301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 TRP A 316
TYR A 111
TYR A 106
GLN A 399
TYR A  75
 RB0  A 501 (-3.9A)
None
None
None
None
 1.45A 3peoC-5iaiA:
0.0
3peoD-5iaiA:
0.0		 3peoC-5iaiA:
20.48
3peoD-5iaiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_H_CU9H301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 TRP A 316
TYR A 111
TYR A 106
GLN A 399
TYR A  75
 RB0  A 501 (-3.9A)
None
None
None
None
 1.46A 3peoH-5iaiA:
0.0
3peoI-5iaiA:
0.0		 3peoH-5iaiA:
20.48
3peoI-5iaiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 11 THR A 300
LEU A 179
ALA A 159
ILE A 298
THR A 249
 None
 1.26A 3qelA-5iaiA:
undetectable
3qelB-5iaiA:
undetectable		 3qelA-5iaiA:
19.32
3qelB-5iaiA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 ARG A 262
GLY A 261
ASN A  46
ASN A 199
TYR A  75
 None
 1.42A 3qwpA-5iaiA:
undetectable		 3qwpA-5iaiA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 THR A  97
PHE A 151
SER A  44
VAL A  70
PHE A 348
 None
 1.33A 3u9fD-5iaiA:
undetectable
3u9fE-5iaiA:
undetectable		 3u9fD-5iaiA:
19.29
3u9fE-5iaiA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 11 THR A  97
PHE A 151
SER A  44
VAL A  70
PHE A 348
 None
 1.41A 3u9fN-5iaiA:
undetectable
3u9fO-5iaiA:
undetectable		 3u9fN-5iaiA:
19.29
3u9fO-5iaiA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 154
PRO A  48
TRP A 316
PHE A  49
 None
None
RB0  A 501 (-3.9A)
None
 1.45A 4grqA-5iaiA:
undetectable
4grqC-5iaiA:
undetectable		 4grqA-5iaiA:
12.84
4grqC-5iaiA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 TYR A 381
GLY A 315
GLY A 314
SER A 138
ALA A 152
 None
RB0  A 501 (-3.7A)
RB0  A 501 ( 4.0A)
None
None
 1.12A 4qtuD-5iaiA:
undetectable		 4qtuD-5iaiA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 ARG A 262
GLY A 261
ASN A  46
ASN A 199
TYR A  75
 None
 1.41A 5ccmA-5iaiA:
undetectable		 5ccmA-5iaiA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 9 SER A 278
GLN A  45
GLY A 317
ILE A 100
ALA A 103
 None
RB0  A 501 ( 4.9A)
None
RB0  A 501 (-4.6A)
None
 1.07A 5entC-5iaiA:
undetectable		 5entC-5iaiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 THR A 300
LEU A 179
ALA A 159
ILE A 298
THR A 249
 None
 1.26A 5ewjC-5iaiA:
2.3
5ewjD-5iaiA:
undetectable		 5ewjC-5iaiA:
21.46
5ewjD-5iaiA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 ARG A 262
GLY A 261
ASN A  46
ASN A 199
TYR A  75
 None
 1.44A 5xxjA-5iaiA:
undetectable		 5xxjA-5iaiA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 5iai SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 12 VAL A 377
THR A  97
PRO A 396
VAL A 157
GLY A 280
 None
 1.39A 6gngB-5iaiA:
undetectable		 6gngB-5iaiA:
22.40