SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iao'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5iao BIFUNCTIONAL PROTEIN
PYRR
(Mycobacterium
tuberculosis) 		5 / 10 ILE A  29
ILE A  33
LEU A  66
ASN A  64
VAL A  78
 None
 1.25A 2nnhB-5iaoA:
undetectable		 2nnhB-5iaoA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5iao BIFUNCTIONAL PROTEIN
PYRR
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 117
ALA A 134
ILE A  85
SER A 130
 None
 1.12A 2othA-5iaoA:
undetectable		 2othA-5iaoA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5iao BIFUNCTIONAL PROTEIN
PYRR
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 146
ALA A 131
ILE A  55
SER A 127
 None
 1.09A 2othA-5iaoA:
undetectable		 2othA-5iaoA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5iao BIFUNCTIONAL PROTEIN
PYRR
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  54
SER A 104
ASP A  84
ILE A  85
THR A  86
 None
 1.12A 3iv6A-5iaoA:
2.2		 3iv6A-5iaoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 5iao BIFUNCTIONAL PROTEIN
PYRR
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 161
ASP A 162
ILE A 116
ILE A  55
LEU A 149
 None
 1.25A 3u7sB-5iaoA:
undetectable		 3u7sB-5iaoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5iao BIFUNCTIONAL PROTEIN
PYRR
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 125
ARG A 126
ASN A 167
LEU A 122
THR A 170
 None
 1.37A 5fhzA-5iaoA:
undetectable		 5fhzA-5iaoA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5iao BIFUNCTIONAL PROTEIN
PYRR
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 157
GLY A 125
SER A 127
SER A 130
 None
 1.26A 5uunA-5iaoA:
undetectable		 5uunA-5iaoA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5iao BIFUNCTIONAL PROTEIN
PYRR
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 159
GLY A 125
SER A 127
SER A 130
 None
 1.22A 5uunA-5iaoA:
undetectable		 5uunA-5iaoA:
22.01