SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JB3_A_SAMA1102_1 (STRUCTURAL PROTEIN VP3)	5iay	E3 UBIQUITIN-PROTEIN LIGASE UHRF1 (Homo sapiens)	3 / 3	ARG A 207 ASP A 190 ASP A 142	None	0.74A	3jb3A-5iayA: undetectable	3jb3A-5iayA: 10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TJ7_A_ACTA609_0 (GBAA_1210 PROTEIN)	5iay	E3 UBIQUITIN-PROTEIN LIGASE UHRF1 (Homo sapiens)	3 / 3	LYS A 187 VAL A 157 HIS A 185	None	0.94A	3tj7A-5iayA: undetectable	3tj7A-5iayA: 21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YIA_B_IMNB401_2 (THYROXINE-BINDING GLOBULIN)	5iay	E3 UBIQUITIN-PROTEIN LIGASE UHRF1 (Homo sapiens)	3 / 3	LEU A 178 ARG A 161 ARG A 175	None	0.74A	4yiaB-5iayA: undetectable	4yiaB-5iayA: 14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGG_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	5iay	E3 UBIQUITIN-PROTEIN LIGASE UHRF1 (Homo sapiens)	4 / 4	VAL A 156 VAL A 186 TYR A 184 GLN A 198	None	1.36A	5qggA-5iayA: undetectable	5qggA-5iayA: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGO_A_ACTA302_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	5iay	E3 UBIQUITIN-PROTEIN LIGASE UHRF1 (Homo sapiens)	4 / 4	VAL A 156 VAL A 186 TYR A 184 GLN A 198	None	1.38A	5qgoA-5iayA: undetectable	5qgoA-5iayA: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGP_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	5iay	E3 UBIQUITIN-PROTEIN LIGASE UHRF1 (Homo sapiens)	4 / 4	VAL A 156 VAL A 186 TYR A 184 GLN A 198	None	1.38A	5qgpA-5iayA: undetectable	5qgpA-5iayA: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGQ_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	5iay	E3 UBIQUITIN-PROTEIN LIGASE UHRF1 (Homo sapiens)	4 / 4	VAL A 156 VAL A 186 TYR A 184 GLN A 198	None	1.33A	5qgqA-5iayA: undetectable	5qgqA-5iayA: 19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QHB_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	5iay	E3 UBIQUITIN-PROTEIN LIGASE UHRF1 (Homo sapiens)	4 / 4	VAL A 156 VAL A 186 TYR A 184 GLN A 198	None	1.35A	5qhbA-5iayA: undetectable	5qhbA-5iayA: 19.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3JB3_A_SAMA1102_1","STRUCTURAL PROTEIN VP3","5iay","E3 UBIQUITIN-PROTEIN LIGASE UHRF1","Homo sapiens",3,"ARG A 207;ASP A 190;ASP A 142","None","0.74A","3jb3A-5iayA:undetectable","3jb3A-5iayA:10.05"],["3TJ7_A_ACTA609_0","GBAA_1210 PROTEIN","5iay","E3 UBIQUITIN-PROTEIN LIGASE UHRF1","Homo sapiens",3,"LYS A 187;VAL A 157;HIS A 185","None","0.94A","3tj7A-5iayA:undetectable","3tj7A-5iayA:21.32"],["4YIA_B_IMNB401_2","THYROXINE-BINDING GLOBULIN","5iay","E3 UBIQUITIN-PROTEIN LIGASE UHRF1","Homo sapiens",3,"LEU A 178;ARG A 161;ARG A 175","None","0.74A","4yiaB-5iayA:undetectable","4yiaB-5iayA:14.81"],["5QGG_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","5iay","E3 UBIQUITIN-PROTEIN LIGASE UHRF1","Homo sapiens",4,"VAL A 156;VAL A 186;TYR A 184;GLN A 198","None","1.36A","5qggA-5iayA:undetectable","5qggA-5iayA:19.79"],["5QGO_A_ACTA302_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","5iay","E3 UBIQUITIN-PROTEIN LIGASE UHRF1","Homo sapiens",4,"VAL A 156;VAL A 186;TYR A 184;GLN A 198","None","1.38A","5qgoA-5iayA:undetectable","5qgoA-5iayA:19.79"],["5QGP_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","5iay","E3 UBIQUITIN-PROTEIN LIGASE UHRF1","Homo sapiens",4,"VAL A 156;VAL A 186;TYR A 184;GLN A 198","None","1.38A","5qgpA-5iayA:undetectable","5qgpA-5iayA:19.79"],["5QGQ_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","5iay","E3 UBIQUITIN-PROTEIN LIGASE UHRF1","Homo sapiens",4,"VAL A 156;VAL A 186;TYR A 184;GLN A 198","None","1.33A","5qgqA-5iayA:undetectable","5qgqA-5iayA:19.79"],["5QHB_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","5iay","E3 UBIQUITIN-PROTEIN LIGASE UHRF1","Homo sapiens",4,"VAL A 156;VAL A 186;TYR A 184;GLN A 198","None","1.35A","5qhbA-5iayA:undetectable","5qhbA-5iayA:19.79"]]