SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ic1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5ic1 TALIN-1
(Mus
musculus) 		5 / 12 ILE A1644
ALA A1406
LEU A1403
LEU A1613
ILE A1410
 EDO  A1903 (-4.0A)
None
EDO  A1903 ( 4.6A)
None
None
 1.14A 1bsxA-5ic1A:
undetectable		 1bsxA-5ic1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5ic1 TALIN-1
(Mus
musculus) 		5 / 12 ILE A1644
ALA A1406
LEU A1403
LEU A1613
ILE A1410
 EDO  A1903 (-4.0A)
None
EDO  A1903 ( 4.6A)
None
None
 1.14A 1bsxB-5ic1A:
undetectable		 1bsxB-5ic1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 5ic1 TALIN-1
(Mus
musculus) 		4 / 4 GLN A1466
GLU A1438
ILE A1384
PRO A1383
 EDO  A1901 (-4.1A)
None
None
None
 1.06A 2fcnA-5ic1A:
undetectable		 2fcnA-5ic1A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5ic1 TALIN-1
(Mus
musculus) 		3 / 3 ARG A1469
GLU A1438
GLN A1466
 None
None
EDO  A1901 (-4.1A)
 1.02A 2p16A-5ic1A:
undetectable		 2p16A-5ic1A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5ic1 TALIN-1
(Mus
musculus) 		5 / 12 GLY A1657
ARG A1652
ALA A1443
ASP A1394
GLY A1391
 None
 1.40A 3jzjA-5ic1A:
undetectable		 3jzjA-5ic1A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5ic1 TALIN-1
(Mus
musculus) 		4 / 7 ALA A1610
ALA A1429
ALA A1366
LEU A1433
 None
 0.91A 4du2A-5ic1A:
undetectable		 4du2A-5ic1A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 5ic1 TALIN-1
(Mus
musculus) 		5 / 12 ALA A1610
VAL A1640
LEU A1403
SER A1411
ILE A1410
 None
None
EDO  A1903 ( 4.6A)
None
None
 1.22A 4pd9A-5ic1A:
0.0		 4pd9A-5ic1A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5ic1 TALIN-1
(Mus
musculus) 		4 / 4 VAL A1449
GLY A1448
ARG A1593
VAL A1381
 None
 1.38A 5d4nA-5ic1A:
undetectable
5d4nB-5ic1A:
undetectable		 5d4nA-5ic1A:
11.90
5d4nB-5ic1A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5ic1 TALIN-1
(Mus
musculus) 		5 / 12 ALA A1595
ALA A1444
GLY A1448
SER A1450
PRO A1452
 None
 0.93A 5jglA-5ic1A:
undetectable		 5jglA-5ic1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5ic1 TALIN-1
(Mus
musculus) 		5 / 12 ALA A1595
ALA A1444
GLY A1448
SER A1450
PRO A1452
 None
 0.92A 5jglB-5ic1A:
undetectable		 5jglB-5ic1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 5ic1 TALIN-1
(Mus
musculus) 		5 / 10 VAL A1731
GLY A1728
GLU A1660
ALA A1664
LEU A1776
 None
 1.16A 5x6yB-5ic1A:
undetectable		 5x6yB-5ic1A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 5ic1 TALIN-1
(Mus
musculus) 		5 / 11 VAL A1731
GLY A1728
GLU A1660
ALA A1664
LEU A1776
 None
 1.21A 5x6yC-5ic1A:
undetectable		 5x6yC-5ic1A:
19.26