SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ic7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PHE A 347
GLY A 342
ARG A 344
VAL A 320
 None
 1.18A 1gsfA-5ic7A:
undetectable		 1gsfA-5ic7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PHE A 347
GLY A 342
ARG A 344
VAL A 320
 None
 1.19A 1gsfB-5ic7A:
undetectable		 1gsfB-5ic7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 PHE A 347
GLY A 342
ARG A 344
VAL A 320
 None
 1.19A 1gsfD-5ic7A:
undetectable		 1gsfD-5ic7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 SER A 390
GLY A 396
ASN A 399
GLY A 395
ASP A 391
 None
None
None
None
SO4  A 703 (-4.5A)
 1.40A 1ho5A-5ic7A:
undetectable		 1ho5A-5ic7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ILE A 501
ILE A 526
LYS A 524
THR A 451
 None
 0.98A 1sbrB-5ic7A:
undetectable		 1sbrB-5ic7A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 CYH A 381
GLY A 335
GLY A 336
ASP A 428
GLY A 429
 None
 0.96A 1sqfA-5ic7A:
undetectable		 1sqfA-5ic7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 GLY A 473
GLY A 479
GLY A 478
LEU A 500
ASP A 499
 None
 1.16A 1xdsB-5ic7A:
undetectable		 1xdsB-5ic7A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 GLY A 419
THR A 442
ILE A 434
GLY A 436
 None
 0.79A 2jklC-5ic7A:
undetectable		 2jklC-5ic7A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 GLY A 419
THR A 442
ILE A 434
GLY A 436
 None
 0.80A 2jklF-5ic7A:
undetectable		 2jklF-5ic7A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ASP A 262
THR A 585
PRO A 586
 None
SO4  A 701 (-2.6A)
SO4  A 706 (-4.4A)
 0.41A 2q64B-5ic7A:
undetectable		 2q64B-5ic7A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG A 497
ARG A 481
PRO A 474
 None
SO4  A 704 (-4.0A)
None
 1.11A 2wljA-5ic7A:
undetectable		 2wljA-5ic7A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ILE A 401
ARG A 375
MET A 373
THR A 372
 None
SO4  A 702 (-4.1A)
None
None
 1.39A 3abkN-5ic7A:
undetectable
3abkW-5ic7A:
undetectable		 3abkN-5ic7A:
21.09
3abkW-5ic7A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 9 VAL A 611
ILE A 297
THR A 294
PHE A 340
ILE A 277
 None
 1.37A 3hbbB-5ic7A:
undetectable		 3hbbB-5ic7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 HIS A 319
VAL A 318
ALA A 328
LEU A 325
THR A 323
 None
 1.23A 3mdzA-5ic7A:
undetectable		 3mdzA-5ic7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ASP A 262
THR A 585
PRO A 586
 None
SO4  A 701 (-2.6A)
SO4  A 706 (-4.4A)
 0.54A 3tkgD-5ic7A:
undetectable		 3tkgD-5ic7A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 PHE A 330
VAL A 357
SER A 317
MET A 298
LEU A 290
 None
 1.29A 4a83A-5ic7A:
undetectable		 4a83A-5ic7A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 CYH A 381
GLY A 335
GLY A 336
ASP A 428
GLY A 429
 None
 0.80A 4fp9D-5ic7A:
undetectable		 4fp9D-5ic7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 CYH A 381
GLY A 335
GLY A 336
ASP A 428
GLY A 429
 None
 0.85A 4fzvA-5ic7A:
undetectable		 4fzvA-5ic7A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ILE A 288
ASP A 334
GLY A 335
PHE A 330
 None
 0.88A 4iqqB-5ic7A:
undetectable		 4iqqB-5ic7A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ARG A 497
GLY A 479
SER A 427
LEU A 468
 None
 0.97A 5bphB-5ic7A:
undetectable		 5bphB-5ic7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ARG A 497
GLY A 479
SER A 427
LEU A 468
 None
 0.96A 5bphD-5ic7A:
undetectable		 5bphD-5ic7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 338
LEU A 300
PHE A 330
ARG A 285
GLY A 336
 None
 1.32A 5k7uA-5ic7A:
undetectable		 5k7uA-5ic7A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 9 VAL A 545
LEU A 566
ALA A 565
VAL A 604
ILE A 593
 None
 0.94A 5om2A-5ic7A:
undetectable
5om2B-5ic7A:
undetectable		 5om2A-5ic7A:
10.46
5om2B-5ic7A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 276
ALA A 307
ALA A 305
THR A 266
LEU A 613
 None
 1.25A 5tl8A-5ic7A:
undetectable		 5tl8A-5ic7A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 GLN A 411
GLY A 396
ILE A 434
ASP A 438
 None
 0.93A 5vlmH-5ic7A:
undetectable		 5vlmH-5ic7A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 276
ALA A 307
ALA A 305
THR A 266
LEU A 613
 None
 1.22A 6aycA-5ic7A:
undetectable		 6aycA-5ic7A:
11.14