SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ic9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 PHE A 860
GLU A 787
GLY A 789
THR A 853
 None
 1.13A 1icuA-5ic9A:
undetectable
1icuB-5ic9A:
undetectable		 1icuA-5ic9A:
21.83
1icuB-5ic9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 THR A 853
PHE A 860
GLU A 787
GLY A 789
 None
 1.10A 1icuC-5ic9A:
undetectable
1icuD-5ic9A:
undetectable		 1icuC-5ic9A:
21.83
1icuD-5ic9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 THR A 853
PHE A 860
GLU A 787
GLY A 789
 None
 1.17A 1kqbC-5ic9A:
undetectable
1kqbD-5ic9A:
undetectable		 1kqbC-5ic9A:
20.17
1kqbD-5ic9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 785
LEU A 834
THR A 853
SER A 856
LEU A 846
 None
 1.09A 1rg7A-5ic9A:
undetectable		 1rg7A-5ic9A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLL_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 10 LEU B 810
LEU B 811
LEU B 856
HIS B 837
LEU B 801
 None
 1.48A 3ollA-5ic9B:
undetectable		 3ollA-5ic9B:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 TYR B 871
LEU A 873
ARG B 873
 None
 0.77A 3sufB-5ic9B:
undetectable		 3sufB-5ic9B:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ASN A 870
PRO A 872
ARG B 873
ALA B 820
 None
 1.08A 3twpB-5ic9A:
2.2		 3twpB-5ic9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ASN A 870
PRO A 872
ARG B 873
ALA B 820
 None
 1.06A 3twpC-5ic9A:
2.4		 3twpC-5ic9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 9 LEU A 906
ILE A 877
LEU A 873
VAL A 871
THR A 874
 None
 1.23A 4x3mB-5ic9A:
undetectable		 4x3mB-5ic9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 CYH A 875
LEU A 910
LEU A 906
ALA A 909
 None
 1.13A 5hpuA-5ic9A:
undetectable
5hpuB-5ic9A:
undetectable		 5hpuA-5ic9A:
8.86
5hpuB-5ic9A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 VAL B 829
PHE B 774
VAL B 777
ILE B 758
LEU B 798
 None
 0.91A 6h1lB-5ic9B:
undetectable		 6h1lB-5ic9B:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 899
THR A 853
ILE A 854
ALA A 865
LEU A 786
 None
 1.29A 6ie8A-5ic9A:
2.5		 6ie8A-5ic9A:
24.26