SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ica'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ica PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 THR A 853
PHE A 860
GLU A 787
GLY A 789
 None
 1.16A 1icuC-5icaA:
undetectable
1icuD-5icaA:
undetectable		 1icuC-5icaA:
22.52
1icuD-5icaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 VAL B 859
VAL A 927
TYR D 839
ARG B 812
 None
 1.20A 1t46A-5icaB:
undetectable		 1t46A-5icaB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 PHE D 738
LEU D 791
ALA D 820
ARG D 772
LEU D 774
 None
 1.44A 2v0mA-5icaD:
undetectable		 2v0mA-5icaD:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 PHE D 765
GLY D 802
PHE D 776
PHE D 738
 None
 1.09A 3ko0R-5icaD:
undetectable
3ko0T-5icaD:
undetectable		 3ko0R-5icaD:
21.85
3ko0T-5icaD:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN
PUTATIVE U3 SNORNP
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 MET C1007
MET C 995
TYR D 843
 None
 1.20A 4p6xI-5icaC:
undetectable		 4p6xI-5icaC:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 5ica PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 LEU A 849
SER A 856
THR A 898
VAL A 881
 None
 1.02A 4wnvD-5icaA:
undetectable		 4wnvD-5icaA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ASN D 808
TYR D 769
LEU D 773
PHE D 776
 None
 1.23A 4yv5A-5icaD:
undetectable		 4yv5A-5icaD:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN
PUTATIVE U3 SNORNP
PROTEIN
(Chaetomium
thermophilum) 		5 / 9 LEU C1044
ASP D 799
GLY D 802
LEU D 805
LEU D 774
 None
 1.05A 5dqfA-5icaC:
undetectable		 5dqfA-5icaC:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 5ica PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN
PUTATIVE U3 SNORNP
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ILE D 830
MET C 995
ASP D 835
 None
 0.62A 5h2uA-5icaD:
undetectable		 5h2uA-5icaD:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5ica PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 CYH A 875
LEU A 910
LEU A 906
ALA A 909
 None
 1.08A 5hpuA-5icaA:
undetectable
5hpuB-5icaA:
undetectable		 5hpuA-5icaA:
11.02
5hpuB-5icaA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5ica PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE B 806
GLU A 916
ALA A 922
ALA A 923
VAL A 927
 None
 1.09A 5igjA-5icaB:
undetectable		 5igjA-5icaB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5ica PUTATIVE
UNCHARACTERIZED
PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		5 / 12 ILE B 806
GLU A 916
ALA A 922
ALA A 923
VAL A 927
 None
 1.07A 5igpA-5icaB:
undetectable		 5igpA-5icaB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 5ica PUTATIVE U3 SNORNP
PROTEIN
PERIODIC TRYPTOPHAN
PROTEIN 2-LIKE
PROTEIN
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		4 / 8 GLY C1017
TRP C1019
VAL D 841
ASP D 842
 None
 1.05A 5vlmA-5icaC:
2.9		 5vlmA-5icaC:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5ica PUTATIVE U3 SNORNP
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 TYR C 937
GLU C 942
GLY C 931
GLY C 932
 None
 0.89A 5x7pB-5icaC:
undetectable		 5x7pB-5icaC:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ica PUTATIVE U3 SNORNP
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ILE C1006
LEU C 971
MET C 995
THR C 996
 None
 1.13A 6nmfN-5icaC:
undetectable
6nmfW-5icaC:
undetectable		 6nmfN-5icaC:
18.55
6nmfW-5icaC:
14.46