SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5icg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		5 / 11 VAL A 344
LEU A 177
SER A 175
LEU A 172
THR A 336
 None
 1.17A 1mmtA-5icgA:
undetectable		 1mmtA-5icgA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		5 / 11 LEU A  70
LEU A  52
SER A  58
LEU A  56
LEU A  66
 None
 1.11A 2ceoA-5icgA:
undetectable		 2ceoA-5icgA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		5 / 12 HIS A 256
VAL A 341
GLN A 342
LEU A 172
ILE A 173
 None
 1.35A 2fj1A-5icgA:
undetectable		 2fj1A-5icgA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		5 / 10 ILE A  39
PHE A  79
LEU A  66
VAL A  69
LEU A  70
 None
 1.21A 2w98A-5icgA:
undetectable		 2w98A-5icgA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		5 / 11 LEU A 172
ALA A 176
ILE A 173
ILE A 286
GLN A 342
 None
 1.12A 3b2rB-5icgA:
undetectable		 3b2rB-5icgA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		3 / 3 LEU A 301
LYS A 298
THR A 297
 None
 0.63A 4lj0A-5icgA:
undetectable		 4lj0A-5icgA:
11.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		5 / 12 ASP A 193
GLY A 195
ASP A 218
ILE A 254
TRP A 258
 None
 0.90A 4pghB-5icgA:
30.2		 4pghB-5icgA:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		5 / 12 ASP A 193
GLY A 195
ILE A 254
ASP A 257
TRP A 258
 None
 0.72A 4pghB-5icgA:
30.2		 4pghB-5icgA:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		5 / 12 GLY A 195
THR A 170
ILE A 254
ASP A 257
TRP A 258
 None
 1.28A 4pghB-5icgA:
30.2		 4pghB-5icgA:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		5 / 12 GLY A 195
GLY A 196
ASP A 218
ILE A 254
TRP A 258
 None
 0.85A 4pghD-5icgA:
31.1		 4pghD-5icgA:
36.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		5 / 12 GLY A 195
GLY A 196
ASP A 218
LYS A 252
ILE A 254
 None
 1.00A 4pghD-5icgA:
31.1		 4pghD-5icgA:
36.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		4 / 6 PHE A  79
VAL A  27
LEU A  34
LEU A  36
 None
 1.00A 6e43A-5icgA:
undetectable		 6e43A-5icgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		4 / 6 PHE A  79
VAL A  27
LEU A  34
LEU A  36
 None
 1.01A 6e43B-5icgA:
undetectable		 6e43B-5icgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		4 / 6 PHE A  79
VAL A  27
LEU A  34
LEU A  36
 None
 1.02A 6e43C-5icgA:
undetectable		 6e43C-5icgA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E
(Thalictrum
flavum) 		3 / 3 TRP A 321
ILE A 286
ASP A 285
 None
 0.91A 6i0y7-5icgA:
undetectable		 6i0y7-5icgA:
7.64