SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5icl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DJR_F_BEZF1305_0
(HEAT-LABILE
ENTEROTOXIN)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 TYR A 239
ARG A  12
ASN A 245
TRP A 244
 None
 1.17A 1djrF-5iclA:
0.0		 1djrF-5iclA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 PHE A 145
ILE A 234
ASN A  14
ASN A  37
LEU A  69
 None
 0.97A 1fm4A-5iclA:
undetectable		 1fm4A-5iclA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 MET A 269
ASN A 270
GLY A 300
TYR A 303
GLN A 314
 None
 1.47A 1h1dA-5iclA:
undetectable		 1h1dA-5iclA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		3 / 3 TRP A 228
TYR A  20
LEU A  33
 None
 1.06A 1kxhA-5iclA:
undetectable		 1kxhA-5iclA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 HIS A 147
ALA A 146
PHE A  86
GLY A 148
 LAQ  A 401 (-3.7A)
None
None
LAQ  A 401 ( 3.8A)
 1.23A 1mj2B-5iclA:
undetectable		 1mj2B-5iclA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 HIS A 147
ALA A 146
PHE A  86
GLY A 148
 LAQ  A 401 (-3.7A)
None
None
LAQ  A 401 ( 3.8A)
 1.26A 1mj2D-5iclA:
undetectable		 1mj2D-5iclA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 HIS A 147
ALA A 146
PHE A  86
GLY A 148
 LAQ  A 401 (-3.7A)
None
None
LAQ  A 401 ( 3.8A)
 1.23A 1mjoB-5iclA:
undetectable		 1mjoB-5iclA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 HIS A 147
ALA A 146
PHE A  86
GLY A 148
 LAQ  A 401 (-3.7A)
None
None
LAQ  A 401 ( 3.8A)
 1.24A 1mjoA-5iclA:
undetectable		 1mjoA-5iclA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 HIS A 147
ALA A 146
PHE A  86
GLY A 148
 LAQ  A 401 (-3.7A)
None
None
LAQ  A 401 ( 3.8A)
 1.25A 1mjoD-5iclA:
undetectable		 1mjoD-5iclA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 8 TYR A 239
TYR A 138
PHE A 145
GLY A  71
 None
 1.01A 2ha4A-5iclA:
undetectable		 2ha4A-5iclA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 SER A  85
ILE A  87
VAL A   4
TYR A  35
LEU A  15
 None
None
None
LAQ  A 401 (-4.9A)
None
 1.19A 2japA-5iclA:
undetectable		 2japA-5iclA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 SER A  85
ILE A  87
VAL A   4
TYR A  35
LEU A  15
 None
None
None
LAQ  A 401 (-4.9A)
None
 1.18A 2japC-5iclA:
undetectable		 2japC-5iclA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 11 THR A 198
ILE A 205
ASN A   9
LEU A 150
LEU A  32
 None
 1.26A 3a51A-5iclA:
undetectable		 3a51A-5iclA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 PHE A 145
HIS A  77
LEU A  82
LEU A  32
LEU A  15
 None
LAQ  A 401 (-4.5A)
None
None
None
 1.16A 3adsA-5iclA:
undetectable		 3adsA-5iclA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 7 LEU A  15
GLY A  71
ALA A 136
PHE A 286
 None
None
LAQ  A 401 ( 4.3A)
None
 0.81A 3tehB-5iclA:
undetectable		 3tehB-5iclA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 PHE A  84
LEU A 125
ILE A 209
PHE A  -2
ALA A  99
 None
 1.06A 4a6dA-5iclA:
undetectable		 4a6dA-5iclA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 PHE A  84
LEU A 125
ILE A 209
PHE A  -2
ALA A  99
 None
 1.08A 4a6eA-5iclA:
undetectable		 4a6eA-5iclA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 7 MET A 196
ASP A 192
SER A 190
GLU A 204
 None
 1.10A 4aq7A-5iclA:
undetectable		 4aq7A-5iclA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 LEU A  82
ILE A 105
GLU A  18
GLY A 148
GLY A 134
 None
None
None
LAQ  A 401 ( 3.8A)
LAQ  A 401 (-3.2A)
 1.15A 4hfpB-5iclA:
undetectable		 4hfpB-5iclA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 PHE A 260
ARG A  96
GLY A 287
ILE A 291
LEU A 329
 None
 1.15A 4kotA-5iclA:
undetectable		 4kotA-5iclA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 8 GLY A 283
ILE A  42
GLY A  71
PHE A 285
 None
LAQ  A 401 ( 4.1A)
None
None
 0.67A 5alcL-5iclA:
undetectable		 5alcL-5iclA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 5 GLY A 283
SER A 264
ARG A 259
GLY A 263
 None
 1.03A 5kprA-5iclA:
undetectable		 5kprA-5iclA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 GLU A  29
PRO A  30
ILE A  31
LEU A  27
 None
 1.24A 5m45A-5iclA:
undetectable		 5m45A-5iclA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 GLU A  29
PRO A  30
ILE A  31
LEU A  27
 None
 1.25A 5m45G-5iclA:
0.5		 5m45G-5iclA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 4 GLU A  29
PRO A  30
ILE A  31
LEU A  27
 None
 1.21A 5m45J-5iclA:
undetectable		 5m45J-5iclA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 6 ASN A  81
THR A 149
ASN A  83
ILE A  42
 LAQ  A 401 (-3.8A)
LAQ  A 401 (-3.1A)
LAQ  A 401 ( 4.2A)
LAQ  A 401 ( 4.1A)
 0.96A 5uigA-5iclA:
undetectable		 5uigA-5iclA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 5 LEU A 109
PHE A 132
LEU A 150
PHE A  84
 None
 1.00A 5x19C-5iclA:
undetectable
5x19J-5iclA:
undetectable		 5x19C-5iclA:
20.22
5x19J-5iclA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5icl LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		3 / 3 THR A 102
GLU A  18
ASN A 135
 None
 0.64A 6nj9K-5iclA:
undetectable		 6nj9K-5iclA:
22.68