SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5icq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 8 PHE A  96
GLY A  90
LEU A 265
VAL A 232
 None
 1.03A 1gsfC-5icqA:
2.3		 1gsfC-5icqA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 7 LEU A  66
TYR A 285
GLY A  69
TRP A 605
 None
 1.03A 1lweA-5icqA:
3.2		 1lweA-5icqA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 4 SER A 465
VAL A 473
PHE A 346
VAL A 351
 None
 1.48A 1o86A-5icqA:
undetectable		 1o86A-5icqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		5 / 12 ASN A  81
GLY A 159
GLN A 163
LEU A 208
THR A 217
 None
 1.46A 1p93C-5icqA:
undetectable		 1p93C-5icqA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 7 VAL A 181
VAL A 202
ALA A 115
LEU A 131
 None
 0.85A 1pthA-5icqA:
undetectable		 1pthA-5icqA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 7 VAL A 181
VAL A 202
ALA A 115
LEU A 131
 None
 0.85A 1pthB-5icqA:
undetectable		 1pthB-5icqA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		5 / 12 ARG A 431
LEU A 466
ILE A 469
PHE A 333
PHE A 326
 None
 1.44A 1y0xX-5icqA:
undetectable		 1y0xX-5icqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 5 PHE A 137
THR A 144
LEU A 131
ALA A 135
 None
 1.31A 2e1qD-5icqA:
undetectable		 2e1qD-5icqA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 5 THR A 552
ARG A 555
ALA A 556
ARG A 559
 None
 0.79A 2qhfA-5icqA:
undetectable		 2qhfA-5icqA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		6 / 12 ARG A 339
PHE A 342
PRO A 406
VAL A 471
LEU A 338
PHE A 444
 None
 1.39A 2zzmA-5icqA:
undetectable		 2zzmA-5icqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		5 / 12 ARG A 339
PHE A 342
PRO A 406
VAL A 471
PHE A 444
 None
 1.30A 2zznA-5icqA:
undetectable		 2zznA-5icqA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 6 LEU A 313
GLU A 311
TRP A 605
SER A 590
 None
 1.46A 3i9jB-5icqA:
undetectable		 3i9jB-5icqA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 7 ALA A 396
ILE A 398
ARG A 384
GLY A 401
 SO4  A 703 (-3.6A)
None
None
None
 0.99A 3v4tH-5icqA:
undetectable		 3v4tH-5icqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 6 PRO A 505
GLY A 506
ASN A 507
LEU A 542
 None
 0.91A 3zqtA-5icqA:
undetectable		 3zqtA-5icqA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 7 VAL A 554
TYR A 557
LEU A 561
ASN A 317
 None
 0.73A 4e1gB-5icqA:
undetectable		 4e1gB-5icqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		5 / 10 TYR A 557
VAL A 394
ILE A 398
TYR A 499
LEU A 321
 None
 1.43A 4jq4B-5icqA:
undetectable		 4jq4B-5icqA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 7 LEU A 541
ARG A 124
PRO A 318
SER A 370
 None
 1.07A 4klrA-5icqA:
undetectable		 4klrA-5icqA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		5 / 12 LEU A  70
ALA A 579
ILE A 584
LEU A 602
GLY A 599
 None
 0.98A 4r3aB-5icqA:
undetectable		 4r3aB-5icqA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 8 ASP A 409
ASP A 414
ILE A 469
TYR A 462
 None
 1.03A 4xjeA-5icqA:
undetectable		 4xjeA-5icqA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 8 ASP A 409
ASP A 414
ILE A 469
TYR A 462
 None
 1.06A 5cfsA-5icqA:
1.9		 5cfsA-5icqA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		5 / 10 ALA A 341
GLU A 340
LEU A 424
ARG A 395
GLY A 429
 None
None
None
SO4  A 703 (-3.7A)
None
 1.36A 5dxbA-5icqA:
undetectable		 5dxbA-5icqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 6 LEU A  77
SER A  76
PHE A  74
ASP A  75
 None
 1.18A 5om3A-5icqA:
undetectable
5om3B-5icqA:
undetectable		 5om3A-5icqA:
7.98
5om3B-5icqA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		3 / 3 ARG A 362
PRO A 406
TYR A 462
 None
 0.84A 5tzoB-5icqA:
undetectable		 5tzoB-5icqA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		4 / 7 GLY A 497
TRP A 513
GLN A 509
TYR A 557
 None
 1.23A 5vlmG-5icqA:
undetectable		 5vlmG-5icqA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5icq METHYLOCYSTIS PARVUS
OBBP MBNE
(Methylocystis
parvus) 		5 / 9 ALA A 341
GLU A 340
LEU A 424
ARG A 395
GLY A 429
 None
None
None
SO4  A 703 (-3.7A)
None
 1.39A 5wgqA-5icqA:
undetectable		 5wgqA-5icqA:
9.29