SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ict'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		5 / 12 LYS A 110
PRO A 111
MET A 113
LEU A 244
LEU A 252
 None
 0.98A 1lbcA-5ictA:
39.8
1lbcC-5ictA:
39.9		 1lbcA-5ictA:
56.34
1lbcC-5ictA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_B_CYZB329_1
(GLUTAMINE RECEPTOR 2)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		5 / 9 LYS A 110
PRO A 111
MET A 113
LEU A 244
LEU A 252
 None
 0.96A 1lbcB-5ictA:
39.9		 1lbcB-5ictA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		5 / 12 LYS A 110
PRO A 111
MET A 113
LEU A 244
LEU A 252
 None
 0.92A 1lbcA-5ictA:
39.8
1lbcC-5ictA:
39.9		 1lbcA-5ictA:
56.34
1lbcC-5ictA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		5 / 11 LYS A 110
PRO A 111
MET A 113
LEU A 244
LEU A 252
 None
 1.00A 3h6tA-5ictA:
39.2
3h6tC-5ictA:
39.1		 3h6tA-5ictA:
56.34
3h6tC-5ictA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_B_CYZB265_1
(GLUTAMATE RECEPTOR 2)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		5 / 9 LYS A 110
PRO A 111
MET A 113
LEU A 244
LEU A 252
 None
 0.98A 3h6tB-5ictA:
39.0		 3h6tB-5ictA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		5 / 11 LYS A 110
PRO A 111
MET A 113
LEU A 244
LEU A 252
 None
 0.92A 3h6tA-5ictA:
39.2
3h6tC-5ictA:
39.1		 3h6tA-5ictA:
56.34
3h6tC-5ictA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		5 / 12 LYS A 110
PRO A 111
MET A 113
LEU A 244
LEU A 252
 None
 0.98A 3iltB-5ictA:
35.9
3iltE-5ictA:
35.6		 3iltB-5ictA:
55.81
3iltE-5ictA:
55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		5 / 10 LYS A 110
PRO A 111
MET A 113
LEU A 244
LEU A 252
 None
 0.98A 3iltB-5ictA:
35.9
3iltE-5ictA:
35.6		 3iltB-5ictA:
55.81
3iltE-5ictA:
55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		4 / 8 TYR A  40
PRO A 111
MET A 113
LEU A 252
 None
 0.27A 3lsfH-5ictA:
39.5		 3lsfH-5ictA:
55.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		5 / 12 LEU A  60
VAL A  61
SER A  12
SER A  94
LEU A 144
 None
None
None
None
GLU  A 301 ( 3.8A)
 1.22A 3m7rA-5ictA:
undetectable		 3m7rA-5ictA:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_1
(GLUTAMATE RECEPTOR 2)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		5 / 9 LYS A 110
PRO A 111
MET A 113
LEU A 244
LEU A 252
 None
 0.97A 3tkdA-5ictA:
39.2		 3tkdA-5ictA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		4 / 5 ILE A  98
PRO A 111
LYS A 223
GLY A 224
 None
 0.22A 3tkdB-5ictA:
38.6		 3tkdB-5ictA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		4 / 5 ILE A  98
PRO A 111
LYS A 223
GLY A 224
 None
 0.20A 3tkdA-5ictA:
39.2		 3tkdA-5ictA:
56.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_2
(GLUTAMATE RECEPTOR 2)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		5 / 9 LYS A 110
PRO A 111
MET A 113
LEU A 244
LEU A 252
 None
 0.99A 3tkdB-5ictA:
38.6		 3tkdB-5ictA:
56.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		4 / 5 VAL A 186
LEU A 195
ASN A 206
VAL A 205
 None
 0.81A 4a9kB-5ictA:
undetectable		 4a9kB-5ictA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		5 / 12 GLU A  57
TYR A   9
ILE A  58
ILE A  93
SER A  13
 None
 1.49A 4xudA-5ictA:
undetectable		 4xudA-5ictA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		4 / 7 LEU A 133
THR A 149
TRP A 165
MET A 168
 None
GLU  A 301 (-3.4A)
None
None
 1.43A 5ljcA-5ictA:
undetectable		 5ljcA-5ictA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		4 / 5 THR A  99
GLU A 151
HIS A 177
LEU A 144
 None
None
None
GLU  A 301 ( 3.8A)
 1.33A 5utuH-5ictA:
undetectable		 5utuH-5ictA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5ict GLUTAMATE RECEPTOR 1
(Drosophila
melanogaster) 		4 / 5 VAL A 227
THR A 229
LEU A  44
LEU A  20
 None
 0.84A 6bqgA-5ictA:
undetectable		 6bqgA-5ictA:
16.60