SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5icv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5icv N-ALPHA-ACETYLTRANSF
ERASE 60
(Homo
sapiens) 		5 / 11 LEU A 116
ALA A  69
LEU A  99
SER A 100
LEU A 101
 None
 1.19A 2c12F-5icvA:
undetectable		 2c12F-5icvA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 5icv N-ALPHA-ACETYLTRANSF
ERASE 60
(Homo
sapiens) 		5 / 12 PHE A 175
TYR A 177
ASP A  81
ASN A 148
ALA A 146
 None
 1.27A 2vdmA-5icvA:
undetectable
2vdmB-5icvA:
undetectable		 2vdmA-5icvA:
17.31
2vdmB-5icvA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5icv N-ALPHA-ACETYLTRANSF
ERASE 60
(Homo
sapiens) 		4 / 8 HIS A 138
ASP A  81
ILE A  77
VAL A  95
 None
 0.81A 3fi0B-5icvA:
undetectable		 3fi0B-5icvA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5icv N-ALPHA-ACETYLTRANSF
ERASE 60
(Homo
sapiens) 		4 / 7 HIS A 138
ASP A  81
ILE A  77
VAL A  95
 None
 0.86A 3fi0E-5icvA:
undetectable		 3fi0E-5icvA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5icv N-ALPHA-ACETYLTRANSF
ERASE 60
(Homo
sapiens) 		5 / 12 ILE A  46
ASP A  81
ILE A  77
ILE A  84
HIS A 138
 None
 1.33A 3phaB-5icvA:
undetectable		 3phaB-5icvA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5icv N-ALPHA-ACETYLTRANSF
ERASE 60
(Homo
sapiens) 		5 / 12 ALA A  56
THR A  58
LEU A  18
THR A  25
GLY A 102
 None
 1.04A 4ypmA-5icvA:
undetectable		 4ypmA-5icvA:
18.09