SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5id6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 6 VAL A 816
ASN A 978
ILE A 993
ASN A 990
 None
 0.91A 1e06A-5id6A:
0.8		 1e06A-5id6A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 6 SER A 462
VAL A 463
LEU A 308
GLU A 313
 None
 0.96A 1fduD-5id6A:
undetectable		 1fduD-5id6A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		5 / 11 LEU A 397
ILE A 358
GLU A 479
ILE A 344
PHE A 352
 None
 1.22A 1gx9A-5id6A:
undetectable		 1gx9A-5id6A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		5 / 12 GLY A 475
ARG A 482
ILE A 336
PHE A 473
TYR A 331
 None
 1.31A 1oltA-5id6A:
undetectable		 1oltA-5id6A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 7 LEU A1014
PHE A1027
LEU A1047
SER A1067
 None
 1.00A 1wrlE-5id6A:
undetectable
1wrlF-5id6A:
undetectable		 1wrlE-5id6A:
5.91
1wrlF-5id6A:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		5 / 12 TYR A1095
LEU A1065
PHE A1127
SER A1029
PHE A1031
 None
 1.50A 1xmuA-5id6A:
undetectable		 1xmuA-5id6A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		5 / 11 PHE A 724
ILE A 704
ILE A 581
LEU A 738
PHE A 728
 None
 1.06A 1z11B-5id6A:
undetectable		 1z11B-5id6A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		5 / 10 PHE A 724
ILE A 704
ILE A 581
LEU A 738
PHE A 728
 None
 1.09A 1z11D-5id6A:
undetectable		 1z11D-5id6A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		5 / 12 TYR A 678
LEU A  17
LEU A 727
ILE A 802
ALA A 801
 None
 0.97A 2bxcA-5id6A:
undetectable		 2bxcA-5id6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 6 LEU A1014
LEU A1047
PRO A1153
VAL A1154
 None
 1.13A 2dqyC-5id6A:
0.8		 2dqyC-5id6A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		3 / 3 LEU A1091
ASN A1070
ARG A1071
 None
 0.92A 2qhfA-5id6A:
undetectable		 2qhfA-5id6A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		5 / 12 THR A 977
ILE A 976
GLY A 991
LEU A 950
ILE A 922
 None
 1.08A 2y7kD-5id6A:
undetectable		 2y7kD-5id6A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 7 TYR A 487
ARG A 482
GLU A 479
SER A 394
 None
 1.14A 2zt7A-5id6A:
undetectable		 2zt7A-5id6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 8 GLU A 672
SER A 658
HIS A 633
CYH A 632
 None
 1.20A 3b9lA-5id6A:
3.7		 3b9lA-5id6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 8 SER A 962
VAL A 908
HIS A 909
CYH A 912
 None
None
G  G  20 ( 4.1A)
None
 1.21A 3b9lA-5id6A:
3.7		 3b9lA-5id6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		3 / 3 TYR A1185
TYR A1221
GLY A 848
 None
 0.74A 3eteB-5id6A:
undetectable
3eteD-5id6A:
undetectable
3eteF-5id6A:
undetectable		 3eteB-5id6A:
18.52
3eteD-5id6A:
18.52
3eteF-5id6A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 7 TYR A 487
LEU A 321
PHE A 328
VAL A 411
 None
 1.07A 3jwqC-5id6A:
undetectable		 3jwqC-5id6A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 7 PHE A 728
VAL A 680
ILE A 581
SER A 739
 None
 0.98A 3pglA-5id6A:
undetectable		 3pglA-5id6A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		3 / 3 LYS A 785
VAL A 757
HIS A 759
 A  G   3 ( 2.9A)
None
A  G   3 ( 4.0A)
 1.17A 3tj7A-5id6A:
undetectable		 3tj7A-5id6A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 5 PHE A 395
PHE A 389
ILE A 344
GLY A 341
 None
 1.03A 4ejjC-5id6A:
undetectable		 4ejjC-5id6A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 7 TYR A1167
TYR A1162
ASN A1182
TYR A 840
 None
 1.32A 4f8yC-5id6A:
undetectable
4f8yD-5id6A:
undetectable		 4f8yC-5id6A:
10.23
4f8yD-5id6A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 4 VAL A 377
THR A 378
GLU A 382
GLU A 379
 None
 1.19A 4l78A-5id6A:
undetectable		 4l78A-5id6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 6 GLU A1088
ASP A1146
GLU A1168
ARG A 836
 None
 1.26A 4ntxA-5id6A:
2.3
4ntxC-5id6A:
1.6		 4ntxA-5id6A:
16.64
4ntxC-5id6A:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		5 / 11 ILE A 829
ALA A1184
LEU A 839
LEU A 950
ILE A 922
 None
 1.08A 4p66A-5id6A:
undetectable		 4p66A-5id6A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		3 / 3 ASP A 535
TYR A 678
TRP A 534
 None
 1.30A 4p7nA-5id6A:
undetectable		 4p7nA-5id6A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 6 TYR A 995
ASN A 928
GLU A 947
PHE A 980
 None
 1.38A 4twdG-5id6A:
undetectable
4twdH-5id6A:
undetectable		 4twdG-5id6A:
13.41
4twdH-5id6A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		3 / 3 GLU A1168
ILE A1072
ALA A1179
 None
 0.65A 4wnwB-5id6A:
undetectable		 4wnwB-5id6A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 6 LEU A 876
ASP A 877
TYR A 903
LEU A 899
 None
None
None
A  G  10 ( 4.4A)
 0.98A 4wozA-5id6A:
undetectable
4wozB-5id6A:
undetectable		 4wozA-5id6A:
14.22
4wozB-5id6A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		5 / 9 LEU A 839
ILE A 904
ILE A 922
VAL A 842
GLU A 925
 None
 1.26A 5igzA-5id6A:
undetectable		 5igzA-5id6A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		5 / 12 ILE A1187
GLY A1183
ALA A1188
ILE A 922
ALA A 923
 None
 1.00A 5n0tB-5id6A:
undetectable		 5n0tB-5id6A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 7 TYR A 995
LEU A 950
THR A 977
VAL A 915
 None
 1.09A 5ov9A-5id6A:
undetectable		 5ov9A-5id6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5id6 CPF1
(Lachnospiraceae
bacterium
ND2006) 		4 / 8 ILE A1195
ILE A1211
THR A 988
TYR A 995
 None
 0.96A 6cduG-5id6A:
4.7
6cduH-5id6A:
4.6		 6cduG-5id6A:
13.29
6cduH-5id6A:
13.29